Potential of Neuroprotective Therapy in Parkinson’s Disease
暂无分享,去创建一个
[1] P. Mecocci,et al. Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain , 1993, Annals of neurology.
[2] J. Lile,et al. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. , 1993, Science.
[3] K. Kieburtz. A controlled trial of lazabemide (RO19–6327) in untreated Parkinson's disease , 1993, Annals of neurology.
[4] H. Kimura,et al. Loss of basic fibroblast growth factor in substantia nigra neurons in Parkinson's disease , 1993, Neurology.
[5] M. Brin,et al. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. , 1993, The New England journal of medicine.
[6] Y. Agid,et al. The glutamate antagonist, MK-801, does not prevent dopaminergic cell death induced by the 1-methyl-4-phenylpyridinium ion (MPP+) in rat dissociated mesencephalic cultures , 1992, Brain Research.
[7] D. Greenberg,et al. Antiparkinsonian drugs and in vitro excitotoxicity , 1992, Brain Research.
[8] C. W. Olanow,et al. Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study , 1992, Brain Research.
[9] A. Kupsch,et al. Do NMDA receptor antagonists protect against MPTP-toxicity? Biochemical and immunocytochemical analyses in black mice , 1992, Brain Research.
[10] K. Jellinger,et al. Iron‐Melanin Complex in Substantia Nigra of Parkinsonian Brains: An X‐Ray Microanalysis , 1992, Journal of neurochemistry.
[11] K. Jellinger,et al. Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease , 1992, Neuroscience Letters.
[12] F. Vaglini,et al. MK‐801 Prevents 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine‐Induced Parkinsonism in Primates , 1992, Journal of neurochemistry.
[13] C. Morris,et al. Uptake and Distribution of Iron and Transferrin in the Adult Rat Brain , 1992, Journal of neurochemistry.
[14] R. Lindsay,et al. Brain‐Derived Neurotrophic Factor Protects Dopamine Neurons Against 6‐Hydroxydopamine and N‐Methyl‐4‐Phenylpyridinium Ion Toxicity: Involvement of the Glutathione System , 1992, Journal of neurochemistry.
[15] B. Summers,et al. Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease , 1992, The Lancet.
[16] Y. Mizuno,et al. Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain , 1992, Journal of the Neurological Sciences.
[17] J. Idle,et al. Mutant debrisoquine hydroxylation genes in Parkinson's disease , 1992, The Lancet.
[18] David L. Felten,et al. Chronic dietary pergolide preserves nigrostriatal neuronal integrity in aged-Fischer-344 rats , 1992, Neurobiology of Aging.
[19] T. Chase,et al. Deprenyl effects on levodopa pharmacodynamics, mood, and free radical scavenging , 1992, Neurology.
[20] K. Sotaniemi,et al. Selegiline as initial treatment in de novo parkinsonian patients , 1992, Neurology.
[21] E. Neafsey,et al. Indole-N-methylated β-carbolinium ions as potential brain-bioactivated neurotoxins , 1992, Brain Research.
[22] L. Loeb,et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. , 1992, The Journal of biological chemistry.
[23] D. Mash,et al. 21‐Aminosteroids Interact with the Dopamine Transporter to Protect Against 1‐Methyl‐4‐Phenylpyridinium‐Induced Neurotoxicity , 1992, Journal of neurochemistry.
[24] S. Ohta,et al. 1‐Methyl‐ 1,2,3,4‐Tetrahydroisoquinoline, Decreasing in 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine‐Treated Mouse, Prevents Parkinsonism‐Like Behavior Abnormalities , 1991, Journal of neurochemistry.
[25] T. Ozawa,et al. Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in parkinson's disease , 1991, Annals of neurology.
[26] F. Jiménez-Jiménez,et al. Acute Effects of 1‐Methyl‐4‐Phenyl‐1, 2, 3, 6‐Tetrahydropyridine in a Model of Rat Designated a Poor Metabolizer of Debrisoquine , 1991, Journal of neurochemistry.
[27] J. Rinne,et al. Selegiline (deprenyl) treatment and death of nigral neurons in Parkinson's disease , 1991, Neurology.
[28] D. Ben-shachar,et al. The Iron Chelator Desferrioxamine (Desferal) Retards 6‐Hydroxydopamine‐Induced Degeneration of Nigrostriatal Dopamine Neurons , 1991, Journal of neurochemistry.
[29] G. Yancopoulos,et al. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra , 1991, Nature.
[30] Y. Agid,et al. Iron and Aluminum Increase in the Substantia Nigra of Patients with Parkinson's Disease: An X‐Ray Microanalysis , 1991, Journal of neurochemistry.
[31] P. Löschmann,et al. Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists , 1991, Nature.
[32] C. Marsden,et al. Anatomic and Disease Specificity of NADH CoQ1 Reductase (Complex I) Deficiency in Parkinson's Disease , 1990, Journal of neurochemistry.
[33] E. Neafsey,et al. Mitochondrial respiratory inhibition by N-methylated beta-carboline derivatives structurally resembling N-methyl-4-phenylpyridine. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[34] S. Orrenius,et al. The role of Ca2+ in cell killing. , 1990, Chemical research in toxicology.
[35] K. Jellinger,et al. Normal Mitochondrial Genome in Brain from Patients with Parkinson's Disease and Complex I Defect , 1990, Journal of neurochemistry.
[36] T. Niwa,et al. Parkinsonism in monkeys produced by chronic administration of an endogenous substance of the brain, tetrahydroisoquinoline: The behavioral and biochemical changes , 1990, Neuroscience Letters.
[37] K. Ohno,et al. Quantitative determination of deleted mitochondrial DNA relative to normal DNA in parkinsonian striatum by a kinetic PCR analysis. , 1990, Biochemical and biophysical research communications.
[38] U. Meyer,et al. Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes. , 1990, The Journal of biological chemistry.
[39] I. Romslo,et al. The role of transferrin in the mechanism of cellular iron uptake. , 1990, The Biochemical journal.
[40] K. Ohno,et al. Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence. , 1990, Biochemical and biophysical research communications.
[41] C. Morris,et al. Brain transferrin receptors and the distribution of cytochrome oxidase. , 1990, Biochemical Society Transactions.
[42] S. Ohta,et al. Postmortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease , 1990, Journal of the Neurological Sciences.
[43] H. Teräväinen. Selegiline in Parkinson's disease , 1990, Acta neurologica Scandinavica.
[44] E. Neafsey,et al. Dopamine uptake inhibitory capacities of β-carboline and 3,4-dihydro-β-carboline analogs of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oxidation products , 1990, Brain Research.
[45] M. Naoi,et al. N-methylisoquinolinium ion as an inhibitor of tyrosine hydroxylase, aromatic l-amino acid decarboxylase and monoamine oxidase , 1989, Neurochemistry International.
[46] S. Fahn. The Endogenous Toxin Hypothesis of the Etiology of Parkinson's Disease and a Pilot Trial of High‐Dosage Antioxidants in an Attempt to Slow the Progression of the Illness , 1989, Annals of the New York Academy of Sciences.
[47] B. Halliwell. Oxidants and the central nervous system: some fundamental questions. Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or stroke? , 1989, Acta neurologica Scandinavica. Supplementum.
[48] P. Riederer,et al. Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration? , 1989, Acta neurologica Scandinavica. Supplementum.
[49] Y. Kagawa,et al. Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease. , 1989, Biochemical and biophysical research communications.
[50] C. Marsden,et al. A Selective Increase in Particulate Superoxide Dismutase Activity in Parkinsonian Substantia Nigra , 1989, Journal of neurochemistry.
[51] J. Langston,et al. The effect of deprenyl (selegiline) on the natural history of Parkinson's disease. , 1989, Science.
[52] J. Bormann. Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels. , 1989, European journal of pharmacology.
[53] L. Golbe. Long‐term efficacy and safety of deprenyl (selegiline) in advanced Parkinson's disease , 1989, Neurology.
[54] M. Naoi,et al. A N-methyltransferase in human brain catalyses N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neurotoxin, N-methylisoquinolinium ion. , 1989, Biochemical and biophysical research communications.
[55] A. H. V. Schapira,et al. MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE , 1989, The Lancet.
[56] C. Marsden,et al. Increased Nigral Iron Content and Alterations in Other Metal Ions Occurring in Brain in Parkinson's Disease , 1989, Journal of neurochemistry.
[57] M. Naoi,et al. Oxidation of N‐Methyl‐1,2,3,4‐Tetrahydroisoquinoline into the N‐Methyl‐Isoquinolinium Ion by Monoamine Oxidase , 1989, Journal of neurochemistry.
[58] Peter Riederer,et al. Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains , 1989, Journal of neurochemistry.
[59] T. Niwa,et al. Migration of tetrahydroisoquinoline, a possible parkinsonian neurotoxin, into monkey brain from blood as proved by gas chromatography-mass spectrometry. , 1988, Journal of chromatography.
[60] R. Marttila,et al. Oxygen toxicity protecting enzymes in Parkinson's disease Increase of superoxide dismutase-like activity in the substantia nigra and basal nucleus , 1988, Journal of the Neurological Sciences.
[61] Y. Mizuno,et al. Studies on the toxicity of 1-methyl-4-phenylpyridinium ion (MPP+) against mitochondria of mouse brain , 1988, Journal of the Neurological Sciences.
[62] R. Skoda,et al. Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[63] T. Nagatsu,et al. An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions , 1988, Neuroscience Letters.
[64] T. Saitoh. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl , 1988, Journal of the Neurological Sciences.
[65] S. Ohta,et al. TETRAHYDROISOQUINOLINE AND 1-METHYL-TETRAHYDROISOQUINOLINE ARE PRESENT IN THE HUMAN BRAIN: RELATION TO PARKINSON’S DISEASE , 1987 .
[66] J. Olney,et al. Anti-parkinsonian agents are phencyclidine agonists and N-methyl-aspartate antagonists. , 1987, European journal of pharmacology.
[67] E. Hall,et al. A nonglucocorticoid steroid analog of methylprednisolone duplicates its high-dose pharmacology in models of central nervous system trauma and neuronal membrane damage. , 1987, The Journal of pharmacology and experimental therapeutics.
[68] N. Sone,et al. Effects of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine and 1‐Methyl‐4‐Phenylpyridinium Ion on Activities of the Enzymes in the Electron Transport System in Mouse Brain , 1987, Journal of neurochemistry.
[69] T. Niwa,et al. Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains. , 1987, Biochemical and biophysical research communications.
[70] P. Dickson,et al. Distribution of transferrin synthesis in brain and other tissues in the rat. , 1987, The Journal of biological chemistry.
[71] M. Eichelbaum,et al. Evidence for polymorphic oxidation of sparteine in Japanese subjects. , 1987, British journal of clinical pharmacology.
[72] Y. Mizuno,et al. Inhibition of mitochondrial alpha-ketoglutarate dehydrogenase by 1-methyl-4-phenylpyridinium ion. , 1987, Biochemical and biophysical research communications.
[73] Voon Wee Yong,et al. Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients , 1986, Neuroscience Letters.
[74] R. Ramsay,et al. Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria. , 1986, The Journal of biological chemistry.
[75] R. Carelli,et al. Ascorbic acid reduces the dopamine depletion induced by methamphetamine and the 1-methyl-4-phenyl pyridinium ion , 1986, Neuropharmacology.
[76] R. Ramsay,et al. Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism. , 1986, Biochemical and biophysical research communications.
[77] V. Yong,et al. Depletion of glutathione in brainstem of mice caused by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is prevented by antioxidant pretreatment , 1986, Neuroscience Letters.
[78] R. Duvoisin,et al. Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity , 1985, Neuroscience Letters.
[79] R. Clavier,et al. Partial protection from the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by four different antioxidants in the mouse , 1985, Neuroscience Letters.
[80] E. Melamed,et al. Suppression of MPTP-induced dopaminergic neurotoxicity in mice by nomifensine andl-DOPA , 1985, Brain Research.
[81] J. Langston,et al. Dopamine uptake blockers protect against the dopamine depleting effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse striatum , 1985, Neuroscience Letters.
[82] S. Kish,et al. Glutathione peroxidase activity in Parkinson's disease brain , 1985, Neuroscience Letters.
[83] C. Pert,et al. Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[84] K. Chiba,et al. Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes. , 1985, Biochemical and biophysical research communications.
[85] E. Neafsey,et al. β-Carboline analogues of N-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP): Endogenous factors underlying idiopathic parkinsonism? , 1985, Neuroscience Letters.
[86] S. Snyder,et al. Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP. , 1984, European journal of pharmacology.
[87] R. Duvoisin,et al. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors , 1984, Nature.
[88] A. Kahn,et al. Expression of the transferrin gene during development of non-hepatic tissues: high level of transferrin mRNA in fetal muscle and adult brain. , 1984, Biochemical and biophysical research communications.
[89] K. Chiba,et al. Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase. , 1984, Biochemical and biophysical research communications.
[90] M. Tarczy,et al. Clinical evaluation of deprenyl (selegiline) in the treatment of Parkinson's disease , 1983, Acta neurologica Scandinavica. Supplementum.
[91] J. Langston,et al. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. , 1983, Science.
[92] M. Greaves,et al. The transferrin receptor , 1982 .
[93] F. Sanger,et al. Sequence and organization of the human mitochondrial genome , 1981, Nature.
[94] Sanford P. Markey,et al. Chronic parkinsonism secondary to intravenous injection of meperidine analogues , 1979, Psychiatry Research.
[95] M. V. Van Woert,et al. Brain peroxidase and catalase in Parkinson disease. , 1975, Archives of neurology.
[96] H. Akita,et al. Effect of piroheptine, a new antiparkinson drug, on dopamine uptake into synaptosomes from corpus striatum of rat brain. , 1972, Arzneimittel-Forschung.
[97] C. Marsden,et al. Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental lewy body disease , 1992, Annals of neurology.
[98] P. Leigh,et al. Erratum: Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease (The Lancet, vol. 339/8806 (1375-1377)) , 1992 .
[99] S. Orrenius,et al. Role of calcium in toxic and programmed cell death. , 1991, Advances in experimental medicine and biology.
[100] S. Fahn,et al. Intraventricular infusion of epidermal growth factor restores dopaminergic pathway in hemiparkinsonian rats , 1991, Movement disorders : official journal of the Movement Disorder Society.
[101] A. S. Gross,et al. The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects. , 1990, Pharmacology & therapeutics.
[102] 小島 孝彦. 3-amino-1-methyl-5H-pyrido[4,3-6]indole (Trp-P-2) and other heterocyclic amines as inhibitors of mitochondrial monoamine oxidases separated from human brain synaptosomes , 1990 .
[103] D. Choi,et al. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. , 1990, Annual review of neuroscience.
[104] J. Olney,et al. Excitotoxic amino acids and neuropsychiatric disorders. , 1990, Annual review of pharmacology and toxicology.
[105] S. Ohta,et al. Metabolism and brain accumulation of tetrahydroisoquinoline (TIQ) a possible parkinsonism inducing substance, in an animal model of a poor debrisoquine metabolizer. , 1990, Life sciences.
[106] Anthony E. Lang,et al. Effect of deprenyl on the progression of disability in early Parkinson's disease. , 1989, The New England journal of medicine.
[107] S. Ohta,et al. Presence of tetrahydroisoquinoline and 1-methyl-tetrahydro-isoquinoline in foods: compounds related to Parkinson's disease. , 1988, Life sciences.
[108] A. Cesura,et al. Reversible, enzyme-activated monoamine oxidase inhibitors: new advances. , 1988, Pharmacological research communications.
[109] E. Carafoli. Intracellular calcium homeostasis. , 1987, Annual review of biochemistry.