We have developed a new 3D multi-physics multi-material code, ALE- AMR, for modeling laser/target effects including debris/shrapnel generation. The code combines Arbitrary Lagrangian Eulerian (ALE) hydrodynamics with Adaptive Mesh Refinement (AMR) to connect the continuum to microstructural regimes. The code is unique in its ability to model hot radiating plasmas and cold fragmenting solids. New numerical techniques were developed for many of the physics packages to work efficiency on a dynamically moving and adapting mesh. A flexible strength/failure framework allows for pluggable material models. Material history arrays are used to store persistent data required by the material models, for instance, the level of accumulated damage or the evolving yield stress in J2 plasticity models. We model ductile metals as well as brittle materials such as Si, Be, and B4C. We use interface reconstruction based on volume fractions of the material components within mixed zones and reconstruct interfaces as needed. This interface reconstruction model is also used for void coalescence and fragmentation. The AMR framework allows for hierarchical material modeling (HMM) with different material models at different levels of refinement. Laser rays are propagated through a virtual composite mesh consisting of the finest resolution representation of the modeled space. A new 2 nd order accurate diffusion solver has been implemented for the thermal conduction and radiation transport packages. The code is validated using laser and x-ray driven spall experiments in the US and France. We present an overview of the code and simulation results.