Homocysteine Levels and Lacunar Brain Infarcts in Elderly Women: The Prospective Population Study of Women in Gothenburg

OBJECTIVES: To examine whether total serum homocysteine (tHcy) in a population‐based sample of middle‐aged women is an independent risk factor for presence of lacunar infarcts (LIs) 24 years later.

[1]  Niels D Prins,et al.  Cerebral small-vessel disease and decline in information processing speed, executive function and memory. , 2005, Brain : a journal of neurology.

[2]  J. Marcusson,et al.  CT Brain Findings in Clinical Dementia Investigation – Underestimation of Mixed Dementia , 2004, Dementia and Geriatric Cognitive Disorders.

[3]  C. Björkelund,et al.  Serum Homocysteine in Relation to Mortality and Morbidity From Coronary Heart Disease: A 24-Year Follow-Up of the Population Study of Women in Gothenburg , 2004, Circulation.

[4]  G. Donnan,et al.  Lacunar Infarction Embolism is the Key Controversies in Stroke , 2004 .

[5]  A. Hofman,et al.  Silent Brain Infarcts and White Matter Lesions Increase Stroke Risk in the General Population: The Rotterdam Scan Study , 2003, Stroke.

[6]  Perminder S. Sachdev,et al.  Homocysteine as a Risk Factor for Cognitive Impairment in Stroke Patients , 2003, Dementia and Geriatric Cognitive Disorders.

[7]  A Hofman,et al.  Homocysteine and brain atrophy on MRI of non-demented elderly. , 2003, Brain : a journal of neurology.

[8]  Matthijs Oudkerk,et al.  Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam scan study , 2002, Annals of neurology.

[9]  Sudha Seshadri,et al.  Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease , 2002 .

[10]  R. Howard,et al.  Homocysteine: a risk factor for retinal venous occlusive disease. , 2002, Ophthalmology.

[11]  A. Fox,et al.  Risk factors and outcome of patients with carotid artery stenosis presenting with lacunar stroke , 2000, Neurology.

[12]  M. Cahill,et al.  Raised plasma homocysteine as a risk factor for retinal vascular occlusive disease , 2000, The British journal of ophthalmology.

[13]  A. Fox,et al.  Risk factors and outcome of patients with carotid artery stenosis presenting with lacunar stroke. North American Symptomatic Carotid Endarterectomy Trial Group. , 2000, Neurology.

[14]  S. Vollset,et al.  Total homocysteine and cardiovascular disease , 1999, Journal of internal medicine.

[15]  R. D'Agostino,et al.  Nonfasting Plasma Total Homocysteine Levels and Stroke Incidence in Elderly Persons: The Framingham Study , 1999, Annals of Internal Medicine.

[16]  L. Lissner,et al.  Birth weight, adulthood BMI, and subsequent weight gain in relation to leptin levels in Swedish women. , 1999, Obesity research.

[17]  R Clarke,et al.  Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease. , 1998, Archives of neurology.

[18]  M. Stanton,et al.  Homocysteine and cardiovascular disease , 2011 .

[19]  J. Witteman,et al.  Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC Group. , 1998, Circulation.

[20]  C. Frost,et al.  Variability and determinants of total homocysteine concentrations in plasma in an elderly population. , 1998, Clinical chemistry.

[21]  E. Lesaffre,et al.  Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.

[22]  A. Lindgren,et al.  Hyperhomocysteinaemia—a common finding in a psychogeriatric population , 1996, European journal of clinical investigation.

[23]  S. Ebrahim,et al.  Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men , 1995, The Lancet.

[24]  O L Lopez,et al.  Computed tomography--but not magnetic resonance imaging--identified periventricular white-matter lesions predict symptomatic cerebrovascular disease in probable Alzheimer's disease. , 1995, Archives of neurology.

[25]  I. Skoog,et al.  The Prevalence of White-Matter Lesions on Computed Tomography of the Brain in Demented and Nondemented 85-Year-Olds , 1994, Journal of geriatric psychiatry and neurology.

[26]  H. Refsum,et al.  Homocysteine in frozen plasma samples. A short cut to establish hyperhomocysteinaemia as a risk factor for arteriosclerosis? , 1993, Scandinavian journal of clinical and laboratory investigation.

[27]  J. Weinberger,et al.  Mechanisms in Lacunar Infarction , 1992, Stroke.

[28]  C. Millikan,et al.  The fallacy of the lacune hypothesis. , 1990, Stroke.

[29]  P. Lundberg,et al.  Serum ferritin concentration compared to other iron-store variables in the diagnosis of iron deficiency. , 2009, Scandinavian journal of haematology. Supplementum.

[30]  J. Hardebo,et al.  Moderate Homocysteinemia - A Possible Risk Factor For Arteriosclerotic Cerebrovascular Disease , 1984, Stroke.

[31]  B. Isaksson,et al.  The study of women in Gothenburg 1968-1969--a population study. General design, purpose and sampling results. , 2009, Acta medica Scandinavica.