Metabolism of 14C‐Histamine Given Intrabronchially to Asthmatic Patients

14C‐histamine was administered intrabronchially to asthmatic patients and controls. The urinary excretion of total radioactivity, 14C‐histamine and its radioactive metabolites was measured. It was found that the excretion of total radioactivity was complete within 24 h. The excretion rate was equal to that observed after intravenous injection of 14C‐histamine, indicating a rapid penetration of the bronchial mucosa. However, the diuresis seemed to be of importance for the excretion rate. Histamine inactivation by methylation was more pronounced after intrabronchial than after intravenotis administration.

[1]  B. Pernow,et al.  Urinary excretion of histamine in bronchial asthma. , 2009, Acta medica Scandinavica.

[2]  O. Sjaastad.  Catabolism of orally administered 14C-histamine in man. , 2009, Acta pharmacologica et toxicologica.

[3]  O. Löwhagen,et al.  Studies on Histamine Metabolism in Intrinsic Bronchial Asthma , 1979, Allergy.

[4]  S. Marney,et al.  Plasma histamine changes during provoked bronchospasm in asthmatic patients. , 1976, The Journal of allergy and clinical immunology.

[5]  G. Granerus,et al.  Ion exchange chromatography for quantitative analysis of radioactive histamine metabolites in human urine. , 1974, Scandinavian journal of clinical and laboratory investigation.

[6]  H. Westling.  Editorial: Evaluation of Histamine Metabolism in Man , 1969 .

[7]  J. Kerr,et al.  The metabolism of C14 in histamine in subjects with bronchial asthma. , 1966, The Journal of allergy.

[8]  H. Westling,et al.  CATABOLISM OF C14‐LABELLED HISTAMINE IN PATIENTS WITH ALLERGIC DISEASES 1 , 1962 .

[9]  T. Saldeen,et al.  Formation and destruction of C14 histamine in human lung tissue in vitro. , 1960, The Journal of allergy.

[10]  G. B. Logan,et al.  Urinary excretion of histamine in patients having asthma and hay fever: observations on changes produced by administration of cortisone. , 1954, The Journal of allergy.

[11]  G. Granerus.  Effects of oral histamine, histidine and diet on urinary excretion of histamine, methylhistamine and 1-methyl-4-imidazoleacetic acid in man. , 1968, Scandinavian journal of clinical and laboratory investigation. Supplementum.

[12]  M. Salaspuro,et al.  The effect of ethanol on galactose elimination in rats with normal and choline-deficient fatty livers. , 1968, Scandinavian journal of clinical and laboratory investigation.

[13]  T. White,et al.  Histmaine metabolism in healthy subjects before and during treatment with aminoguanidine. , 1968, Scandinavian journal of clinical and laboratory investigation. Supplementum.

[14]  H. Westling,et al.  The renal removal of C-14-labelled histamine from the blood in man. , 1965, Scandinavian journal of clinical and laboratory investigation.

[15]  G. Beall.  HISTAMINE IN HUMAN URINE. , 1965, International archives of allergy and applied immunology.

[16]  H. Westling,et al.  Catabolism of C-14-labelled histamine in patients with allergic diseases. , 1962, Acta allergologica.