Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

[1]  Matthias Orth,et al.  Expression of Human Apolipoprotein E3 or E4 in the Brains ofApoe−/− Mice: Isoform-Specific Effects on Neurodegeneration , 1999, The Journal of Neuroscience.

[2]  B. Hyman,et al.  Abeta associated neuropil changes: correlation with neuronal loss and dementia. , 1998, Journal of neuropathology and experimental neurology.

[3]  E. Bigio,et al.  Neocortical Synapse Density and Braak Stage in the Lewy Body Variant of Alzheimer Disease: A Comparison with Classic Alzheimer Disease and Normal Aging , 1998, Journal of neuropathology and experimental neurology.

[4]  L. Mucke,et al.  Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[5]  A. Fagan,et al.  Potential role of apoE in structural plasticity in the nervous system; implications for disorders of the central nervous system. , 1998, Trends in cardiovascular medicine.

[6]  A. Roses,et al.  Apolipoprotein E Isoform-Specific Differences in Outcome from Focal Ischemia in Transgenic Mice , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[7]  E. Masliah,et al.  Comparison of Two Quantitative Methods for the Evaluation of Neuronal Number in the Frontal Cortex in Alzheimer Disease , 1997, Journal of neuropathology and experimental neurology.

[8]  J. Haines,et al.  Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis , 1997 .

[9]  D. Price,et al.  Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease , 1997, Journal of neuropathology and experimental neurology.

[10]  A. Hofman,et al.  Apolipoprotein E epsilon4 and the risk of dementia with stroke. A population-based investigation. , 1997, JAMA.

[11]  L. Mucke,et al.  Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo , 1997, Neuroscience.

[12]  A D Roses,et al.  Apolipoprotein E and Alzheimer's Disease A Rapidly Expanding Field with Medical and Epidemiological Consequences , 1996, Annals of the New York Academy of Sciences.

[13]  A. Roses,et al.  Neurodegeneration in the Central Nervous System of apoE-Deficient Mice , 1995, Experimental Neurology.

[14]  B. Tycko,et al.  Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease , 1995, Neurology.

[15]  L. Mucke,et al.  Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice , 1994, Brain Research.

[16]  J. Haines,et al.  Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.

[17]  D. Salmon,et al.  Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment , 1991, Annals of neurology.

[18]  R. Mahley,et al.  Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. , 1988, Science.