Design of integrated crystallization systems

A systematic procedure is developed for designing an integrated crystallization system by considering the interaction between crystallization and downstream processing. Potential problems related to unit operations such as filtration, washing, dewatering, recrystallization, and drying are anticipated and resolved by determining an operating policy and configuration for the crystallizer as well as the downstream units. The approach can be applied to both batch and continuous crystallizers. First, the possible impacts of particle-size distribution (PSD) on the downstream processing units are identified. This forms the basis for determining a target PSD in the second step. Third, possible means by which the desired PSD can be achieved are selected. Fourth, the alternatives thus generated are evaluated and compared to identify the best design. Heuristics are provided along the way to guide the decision making. Shortcut equipment models are used to compare the performance of the alternatives. The procedure is illustrated with two industrial examples, including the production of adipic acid.

[1]  R. N. Hall,et al.  Segregation of Impurities During the Growth of Germanium and Silicon , 1953 .

[2]  R. Prim,et al.  The Distribution of Solute in Crystals Grown from the Melt. Part I. Theoretical , 1953 .

[3]  E. T. White,et al.  Studies on liquid inclusions in crystals , 1966 .

[4]  Stanley Katz,et al.  Dynamic behavior of the well‐mixed isothermal crystallizer , 1967 .

[5]  R. Reid,et al.  Incorporation of ionic impurities in crystals growing from solution. The case of lead ions in potassium chloride crystals , 1967 .

[6]  Richard Brooks,et al.  Occlusion of mother liquor in solution-grown crystals , 1968 .

[7]  M. Larson,et al.  Crystal size distributions in continuous crystallizers when growth rate is size dependent , 1968 .

[8]  J. W. Mullin,et al.  Programmed cooling of batch crystallizers , 1971 .

[9]  J. Keener,et al.  Stability of the class II classified product crystallizer with fines removal , 1973 .

[10]  J. W. Mullin,et al.  Programmed cooling crystallization of potassium sulphate solutions , 1974 .

[11]  James M. Douglas,et al.  Self‐generated oscillations in continuous crystallizers: Part I. Analytical prediction of the oscillating output , 1975 .

[12]  J. Garside,et al.  Crystallization Kinetics from MSMPR Crystallizers , 1980 .

[13]  The effect of crystal size on occlusion formation during crystallization from solution , 1981 .

[14]  Tatsuo Tanaka,et al.  Porosity estimation for random packings of spherical particles , 1984 .

[15]  John Garside,et al.  Industrial crystallization from solution , 1985 .

[16]  Allan S. Myerson,et al.  Solvent selection and batch crystallization , 1986 .

[17]  J. W. Mullin,et al.  Batch crystallization and solid-liquid separation of potassium sulphate , 1987 .

[18]  A. Mersmann,et al.  Chemical engineering aspects of precipitation from solution , 1988 .

[19]  Ka Ming Ng,et al.  Design of solids processes: production of potash , 1988 .

[20]  Alfons Mersmann,et al.  Design of crystallizers , 1988 .

[21]  W. Pietsch.  Size enlargement by agglomeration , 1991 .

[22]  Changhou Liu,et al.  The modelling and simulation of a multistage crystallizer , 1991 .

[23]  Ka Ming Ng,et al.  A generalized Blake‐Kozeny equation for multisized spherical particles , 1991 .

[24]  Å. Rasmuson,et al.  Application of controlled cooling and seeding in batch crystallization , 1992 .

[25]  Luis A. Cisternas,et al.  Process designs for fractional crystallization from solution , 1993 .

[26]  Narayan S. Tavare,et al.  Industrial crystallization : process simulation analysis and design , 1995 .

[27]  Ka Ming Ng,et al.  Fractional crystallization: Design alternatives and tradeoffs , 1995 .

[28]  Ka Ming Ng,et al.  Bypassing eutectics with extractive crystallization: Design alternatives and tradeoffs , 1995 .

[29]  N. Kubota,et al.  LARGE AND MONO-SIZED PRODUCT CRYSTALS FROM NATURAL COOLING MODE BATCH CRYSTALLIZER , 1996 .

[30]  Ka Ming Ng,et al.  Separation of quaternary conjugate salt systems by fractional crystallization , 1996 .

[31]  Ka Ming Ng,et al.  Synthesis of reactive crystallization processes , 1997 .

[32]  Ka Ming Ng,et al.  Synthesis of drowning‐out crystallization‐based separations , 1997 .

[33]  Ka Ming Ng,et al.  Simulation of solids processes accounting for particle‐size distribution , 1997 .

[34]  S. Assouline,et al.  A probabilistic approach towards modeling the relationships between particle and pore size distributions: the multicomponent packed sphere case , 1998 .

[35]  Ka Ming Ng,et al.  Synthesis of processing system around a crystallizer , 1998 .

[36]  N. Kubota,et al.  Seeding Effect on Batch Crystallization of Potassium Sulfate under Natural Cooling Mode and a Simple Design Method of Crystallizer , 1999 .

[37]  D. L. Ma,et al.  Optimal seeding in batch crystallization , 1999 .

[38]  Christianto Wibowo,et al.  Synthesis of bulk solids processing systems , 1999 .

[39]  S. Durbin,et al.  Incorporation of impurity to a tetragonal lysozyme crystal , 1999 .

[40]  L. Biegler,et al.  Dynamic optimization of a batch cooling crystallization process , 1999 .

[41]  Ka Ming Ng,et al.  Design of reactive crystallization systems incorporating kinetics and mass‐transfer effects , 1999 .

[42]  W. J. Genck,et al.  Better growth in batch crystallizers , 2000 .

[43]  Christianto Wibowo,et al.  Unified approach for synthesizing crystallization-based separation processes , 2000 .

[44]  Christianto Wibowo,et al.  Operational issues in solids processing plants: Systems view , 2001 .

[45]  Christianto Wibowo,et al.  Synthesis of chiral crystallization processes , 2001 .