Is treatment with platelet-rich fibrin better than zinc oxide eugenol in cases of established dry socket for controlling pain, reducing inflammation, and improving wound healing?

Objectives To appraise the effectiveness of platelet-rich fibrin (PRF) in the management of established dry socket in terms of pain, inflammation, and wound healing. Materials and Methods Two hundred patients with established alveolar osteitis were studied to determine the efficacy of PRF and zinc oxide eugenol (ZOE) for pain control, inflammation reduction, and wound healing. Patients were randomly allocated to Group A (PRF) or Group B (ZOE). Patients were examined on the 1st, 3rd, 7th, and 14th postoperative day and evaluated for pain using visual analogue scale scores, inflammation with a gingival index score, and wound healing through a determination of the number of bony walls exposed. Results Group A showed better results in terms of pain remission, control of inflammation, and wound healing compared to Group B. Results between groups were statistically significant (P<0.05). Conclusion PRF is a better alternative than ZOE for the effective management of alveolar osteitis.

[1]  P. A. Wahab,et al.  Effectiveness of 0.2% chlorhexidine gel and a eugenol-based paste on postoperative alveolar osteitis in patients having third molars extracted: a randomised controlled clinical trial. , 2015, The British journal of oral & maxillofacial surgery.

[2]  R. Xia,et al.  Effect of oral contraceptive use on the incidence of dry socket in females following impacted mandibular third molar extraction: a meta-analysis. , 2015, International journal of oral and maxillofacial surgery.

[3]  B. Ria,et al.  The Prevention and Management of Dry Socket: Do Antibiotics Have a Role to Play? , 2015, Primary dental journal.

[4]  S. Azzeghaiby,et al.  Systemic review of dry socket: aetiology, treatment, and prevention. , 2015, Journal of clinical and diagnostic research : JCDR.

[5]  M. Eshghpour,et al.  Effect of menstrual cycle on frequency of alveolar osteitis in women undergoing surgical removal of mandibular third molar: a single-blind randomized clinical trial. , 2013, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[6]  V. Ugboko,et al.  Can autologous platelet-rich plasma gel enhance healing after surgical extraction of mandibular third molars? , 2011, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[7]  A. Kolokythas,et al.  Alveolar Osteitis: A Comprehensive Review of Concepts and Controversies , 2010, International journal of dentistry.

[8]  I. Şener,et al.  Comparison of two chlorhexidine rinse protocols on the incidence of alveolar osteitis following the surgical removal of impacted third molars. , 2006, The journal of contemporary dental practice.

[9]  A. Dohan,et al.  Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet-related biologic features. , 2006, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[10]  A. Dohan,et al.  Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. , 2006, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[11]  A. Dohan,et al.  Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. , 2006, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[12]  A. Dohan,et al.  Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part III: leucocyte activation: a new feature for platelet concentrates? , 2006, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[13]  I. Blum.  Contemporary views on dry socket (alveolar osteitis): a clinical appraisal of standardization, aetiopathogenesis and management: a critical review. , 2002, International journal of oral and maxillofacial surgery.

[14]  C. Bloomer.  Alveolar osteitis prevention by immediate placement of medicated packing. , 2000, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[15]  D. Nitzan.  On the genesis of "dry socket". , 1983, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[16]  R. Ross,et al.  A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[17]  G. Fernandes,et al.  Prevention of Alveolar Osteitis. A Case Report and Review of Literature. , 2016, The New York state dental journal.

[18]  B. Singh,et al.  Comparative evaluation of zinc oxide eugenol versus gelatin sponge soaked in plasma rich in growth factor in the treatment of dry socket: An initial study , 2013, Contemporary clinical dentistry.

[19]  M. H. Motamedi,et al.  Effect of plasma rich in growth factors on alveolar osteitis , 2012, National journal of maxillofacial surgery.

[20]  L. Stassen,et al.  The management of dry socket/alveolar osteitis. , 2011, Journal of the Irish Dental Association.

[21]  L. Hedström,et al.  Effect estimates and methodological quality of randomized controlled trials about prevention of alveolar osteitis following tooth extraction: a systematic review. , 2007, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[22]  R. A. Olson,et al.  Alveolar osteitis following surgical removal of mandibular third molars. , 1990, Anesthesia progress.

[23]  H. Birn.  Etiology and pathogenesis of fibrinolytic alveolitis (“dry socket”) , 1973 .

[24]  N. Payidarol.  [Dry socket]. , 1972, Dentoral.