Manufacture of degradable polymeric scaffolds for bone regeneration

Many innovative technology platforms for promoting bone regeneration have been developed. A common theme among these is the use of scaffolds to provide mechanical support and osteoconduction. Scaffolds can be either ceramic or polymer-based, or composites of both classes of material. Both ceramics and polymers have their own merits and drawbacks, and a better solution may be to synergize the advantageous properties of both materials within composite scaffolds. In this current review, after a brief introduction of the anatomy and physiology of bone, different strategies of fabricating polymeric scaffolds for bone regeneration, including traditional and solid free-form fabrication, are critically discussed and compared, while focusing on the advantages and disadvantages of individual techniques.

[1]  Jennifer L West,et al.  Laser‐scanning lithography (LSL) for the soft lithographic patterning of cell‐adhesive self‐assembled monolayers , 2006, Biotechnology and bioengineering.

[2]  I. Shapiro,et al.  Matrix Regulation of Skeletal Cell Apoptosis , 2001, The Journal of Biological Chemistry.

[3]  Byung-Soo Kim,et al.  Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering. , 2006, Biomaterials.

[4]  A. Burstein,et al.  The elastic and ultimate properties of compact bone tissue. , 1975, Journal of biomechanics.

[5]  D W Hutmacher,et al.  Novel PCL-based honeycomb scaffolds as drug delivery systems for rhBMP-2. , 2005, Biomaterials.

[6]  S. Ramakrishna,et al.  Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering. , 2005, Biomaterials.

[7]  David J Mooney,et al.  Fabrication and in vitro testing of polymeric delivery system for condensed DNA. , 2003, Journal of biomedical materials research. Part A.

[8]  M. Marei,et al.  Preservation and regeneration of alveolar bone by tissue-engineered implants. , 2005, Tissue engineering.

[9]  Etienne Burdet,et al.  Microrobotics and MEMS-based fabrication techniques for scaffold-based tissue engineering. , 2005, Macromolecular bioscience.

[10]  Eugene Khor,et al.  Hydroxyapatite-chitin materials as potential tissue engineered bone substitutes. , 2004, Biomaterials.

[11]  Masakazu Kawashita,et al.  Novel bioactive materials with different mechanical properties. , 2003, Biomaterials.

[12]  Dietmar W Hutmacher,et al.  Scaffold-based tissue engineering: rationale for computer-aided design and solid free-form fabrication systems. , 2004, Trends in biotechnology.

[13]  R. Adhikari,et al.  Biodegradable synthetic polymers for tissue engineering. , 2003, European cells & materials.

[14]  Arndt F Schilling,et al.  Leptin Inhibits Bone Formation through a Hypothalamic Relay A Central Control of Bone Mass , 2000, Cell.

[15]  C. Patrick,et al.  Manufacture of porous biodegradable polymer conduits by an extrusion process for guided tissue regeneration. , 1998, Biomaterials.

[16]  P. Robson,et al.  Strategies for Directing the Differentiation of Stem Cells Into the Osteogenic Lineage In Vitro , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[17]  Malcolm N. Cooke,et al.  Use of stereolithography to manufacture critical-sized 3D biodegradable scaffolds for bone ingrowth. , 2003, Journal of biomedical materials research. Part B, Applied biomaterials.

[18]  D. Hutmacher,et al.  Scaffolds in tissue engineering bone and cartilage. , 2000, Biomaterials.

[19]  Dietmar W Hutmacher,et al.  Repair of large articular osteochondral defects using hybrid scaffolds and bone marrow-derived mesenchymal stem cells in a rabbit model. , 2006, Tissue engineering.

[20]  A R Boccaccini,et al.  Porous poly(alpha-hydroxyacid)/Bioglass composite scaffolds for bone tissue engineering. I: Preparation and in vitro characterisation. , 2004, Biomaterials.

[21]  John P. Bilezikian,et al.  Principles of Bone Biology , 1996 .

[22]  Huipin Yuan,et al.  3D microenvironment as essential element for osteoinduction by biomaterials. , 2005, Biomaterials.

[23]  David B. Burr,et al.  Structure, Function, and Adaptation of Compact Bone , 1989 .

[24]  Hyun Chul Lee,et al.  Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue , 2000, Nature.

[25]  A. Ahluwalia,et al.  Fabrication of PLGA scaffolds using soft lithography and microsyringe deposition. , 2003, Biomaterials.

[26]  A. Boccaccini,et al.  Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. , 2006, Biomaterials.

[27]  Vladimir Mironov,et al.  Organ printing: computer-aided jet-based 3D tissue engineering. , 2003, Trends in biotechnology.

[28]  R. Smith.  Biodegradable polymers for industrial applications , 2005 .

[29]  Anthony Atala,et al.  Methods Of Tissue Engineering , 2006 .

[30]  L. Bačáková,et al.  Molecular mechanisms of improved adhesion and growth of an endothelial cell line cultured on polystyrene implanted with fluorine ions. , 2000, Biomaterials.

[31]  Qiong Wu,et al.  Evaluation of three-dimensional scaffolds made of blends of hydroxyapatite and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) for bone reconstruction. , 2004, Biomaterials.

[32]  Michel Vert,et al.  Degradation and cell culture studies on block copolymers prepared by ring opening polymerization of epsilon-caprolactone in the presence of poly(ethylene glycol). , 2004, Journal of biomedical materials research. Part A.

[33]  T. Lim,et al.  Repair of calvarial defects with customized tissue-engineered bone grafts I. Evaluation of osteogenesis in a three-dimensional culture system. , 2003, Tissue engineering.

[34]  Michael A K Liebschner,et al.  Biomechanical considerations of animal models used in tissue engineering of bone. , 2004, Biomaterials.

[35]  S. Teoh,et al.  Scaffold design and in vitro study of osteochondral coculture in a three-dimensional porous polycaprolactone scaffold fabricated by fused deposition modeling. , 2003, Tissue engineering.

[36]  Colleen L Flanagan,et al.  Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. , 2005, Biomaterials.

[37]  K. Leong,et al.  Scaffold development using selective laser sintering of polyetheretherketone-hydroxyapatite biocomposite blends. , 2003, Biomaterials.

[38]  I. Zein,et al.  Fused deposition modeling of novel scaffold architectures for tissue engineering applications. , 2002, Biomaterials.

[39]  E. D. Rekow,et al.  Performance of hydroxyapatite bone repair scaffolds created via three-dimensional fabrication techniques. , 2003, Journal of biomedical materials research. Part A.

[40]  D. Hutmacher,et al.  Osteogenic induction of human bone marrow-derived mesenchymal progenitor cells in novel synthetic polymer-hydrogel matrices. , 2003, Tissue engineering.

[41]  P. Ma,et al.  Microtubular architecture of biodegradable polymer scaffolds. , 2001, Journal of biomedical materials research.

[42]  Eben Alsberg,et al.  Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. , 2004, Bone.

[43]  D L Butler,et al.  Functional tissue engineering: the role of biomechanics. , 2000, Journal of biomechanical engineering.

[44]  Antonios G. Mikos,et al.  Bone tissue engineering , 1995, Nature Medicine.

[45]  Yugyung Lee,et al.  Biomedical applications of collagen. , 2001, International journal of pharmaceutics.

[46]  D. Kaplan,et al.  Porosity of 3D biomaterial scaffolds and osteogenesis. , 2005, Biomaterials.

[47]  Cato T Laurencin,et al.  The sintered microsphere matrix for bone tissue engineering: in vitro osteoconductivity studies. , 2002, Journal of biomedical materials research.

[48]  David J. Mooney,et al.  Polymeric Growth Factor Delivery Strategies for Tissue Engineering , 2003, Pharmaceutical Research.

[49]  J. Hollinger,et al.  Initial biocompatibility studies of a novel degradable polymeric bone substitute that hardens in situ. , 1996, Bone.

[50]  M. Swiontkowski,et al.  Norian SRS cement augmentation in hip fracture treatment. Laboratory and initial clinical results. , 1998, Clinical orthopaedics and related research.

[51]  H. Seitz,et al.  Three-dimensional printing of porous ceramic scaffolds for bone tissue engineering. , 2005, Journal of biomedical materials research. Part B, Applied biomaterials.

[52]  M Kellomäki,et al.  Tyrosine derived polycarbonate membrane is useful for guided bone regeneration in rabbit mandibular defects , 2005, Journal of materials science. Materials in medicine.

[53]  R. Legeros,et al.  Properties of osteoconductive biomaterials: calcium phosphates. , 2002, Clinical orthopaedics and related research.

[54]  J. Wozney.  Overview of Bone Morphogenetic Proteins , 2002, Spine.

[55]  I Zein,et al.  Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling. , 2001, Journal of biomedical materials research.

[56]  E H Burger,et al.  Mineralization processes in demineralized bone matrix grafts in human maxillary sinus floor elevations. , 1999, Journal of biomedical materials research.

[57]  J. Davies,et al.  In vitro degradation of a novel poly(lactide-co-glycolide) 75/25 foam. , 1999, Biomaterials.

[58]  Andrés J. García,et al.  Combined microscale mechanical topography and chemical patterns on polymer cell culture substrates. , 2006, Biomaterials.

[59]  S. Bogdansky,et al.  Effective use of optimized, high-dose (50 kGy) gamma irradiation for pathogen inactivation of human bone allografts. , 2005, Biomaterials.

[60]  V. Sikavitsas,et al.  Biomaterials and bone mechanotransduction. , 2001, Biomaterials.

[61]  H. Ouyang,et al.  The Immunogenicity and Immunomodulatory Function of Osteogenic Cells Differentiated from Mesenchymal Stem Cells , 2006, The Journal of Immunology.

[62]  N. Haas,et al.  Quantification of various growth factors in different demineralized bone matrix preparations. , 2007, Journal of biomedical materials research. Part A.

[63]  M. Wang,et al.  Production and evaluation of biodegradable composites based on PHB-PHV copolymer. , 2002, Biomaterials.

[64]  C. Wilkinson,et al.  New depths in cell behaviour: reactions of cells to nanotopography. , 1999, Biochemical Society symposium.

[65]  D J Mooney,et al.  Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[66]  Emanuel M. Sachs,et al.  Solid free-form fabrication of drug delivery devices , 1996 .

[67]  E. Kastenbauer,et al.  Resorbable polyesters in cartilage engineering: affinity and biocompatibility of polymer fiber structures to chondrocytes. , 1996, Journal of biomedical materials research.

[68]  P H Krebsbach,et al.  Indirect solid free form fabrication of local and global porous, biomimetic and composite 3D polymer-ceramic scaffolds. , 2003, Biomaterials.

[69]  Y. Shikinami,et al.  Bioresorbable devices made of forged composites of hydroxyapatite (HA) particles and poly-L-lactide (PLLA): Part I. Basic characteristics. , 1999, Biomaterials.

[70]  Linbo Wu,et al.  The predicted and observed decline in onchocerciasis infection during 14 years of successful control of Simulium spp. in west Africa. , 2005 .

[71]  T. Park,et al.  A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive. , 2000, Journal of biomedical materials research.

[72]  M. B. Claase,et al.  Design of segmented poly(ether ester) materials and structures for the tissue engineering of bone. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[73]  P. Janmey,et al.  Tissue Cells Feel and Respond to the Stiffness of Their Substrate , 2005, Science.

[74]  Byung-Soo Kim,et al.  A poly(lactide-co-glycolide)/hydroxyapatite composite scaffold with enhanced osteoconductivity. , 2007, Journal of biomedical materials research. Part A.

[75]  S. Hollister,et al.  Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints. , 2002, Biomaterials.

[76]  Steve Weiner,et al.  THE MATERIAL BONE: Structure-Mechanical Function Relations , 1998 .

[77]  Thomas A Einhorn,et al.  Fracture healing as a post‐natal developmental process: Molecular, spatial, and temporal aspects of its regulation , 2003, Journal of cellular biochemistry.

[78]  D. Mooney,et al.  Polymeric system for dual growth factor delivery , 2001, Nature Biotechnology.