Statin neuropathy masquerading as diabetic autoimmune polyneuropathy.
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Statin-induced neuropathy is increasingly described. Proposed mechanisms include an alteration in cholesterol synthesis, producing a disturbance in the cholesterol-rich neuronal membrane, or in the activity of ubiquinone (coenzyme Q10), a mitochondrial respiratory chain enzyme inhibited by statins leading to neuronal damage (1). The entire class is implicated, and both polyneuropathy and mononeuropathy have been described with improvement or even complete resolution occurring with cessation of therapy (1). In all cases, clinical improvement occurred soon after statins were discontinued, and in the absence of specific clinical, …
[1] P. Howard,et al. Association of HMG-CoA Reductase Inhibitors with Neuropathy , 2003, The Annals of pharmacotherapy.
[2] J. Hallas,et al. Statins and risk of polyneuropathy: A case-control study , 2002, Neurology.