论文信息 - Computational design of enzymes.

Computational design of enzymes.

The de novo design of enzymes with activities not found in natural biocatalysts is a major challenge for molecular biology. Sophisticated computational methods have recently led to impressive progress in this exciting and rapidly evolving field (Röthlisberger et al., 2008; Jiang et al., 2008).

[1] John Alan Gerlt,et al. Evolution of function in (β/α)8-barrel enzymes , 2003 .

[2] D. Hilvert,et al. Nonspecific medium effects versus specific group positioning in the antibody and albumin catalysis of the base-promoted ring-opening reactions of benzisoxazoles. , 2004, Journal of the American Chemical Society.

[3] R F Doolittle,et al. Protein Evolution , 1968, Nature.

[4] B List,et al. Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[5] F. Arnold,et al. Evolving strategies for enzyme engineering. , 2005, Current opinion in structural biology.

[6] Donald Hilvert,et al. Minimalist active-site redesign: teaching old enzymes new tricks. , 2007, Angewandte Chemie.

[7] Eric A. Althoff,et al. Kemp elimination catalysts by computational enzyme design , 2008, Nature.

[8] Eric A. Althoff,et al. De Novo Computational Design of Retro-Aldol Enzymes , 2008, Science.

[9] Birte Höcker,et al. Catalytic versatility, stability, and evolution of the (betaalpha)8-barrel enzyme fold. , 2005, Chemical reviews.

[10] Jens Meiler,et al. New algorithms and an in silico benchmark for computational enzyme design , 2006, Protein science : a publication of the Protein Society.