Genome-wide association studies of 74 plasma metabolites of German shepherd dogs reveal two metabolites associated with genes encoding their enzymes

[1]  T. Spector,et al.  Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk , 2019, Cell metabolism.

[2]  M. Rothschild,et al.  Genome-wide association studies of inflammatory bowel disease in German shepherd dogs , 2018, PloS one.

[3]  E. A. Hafez,et al.  Synopsis of arachidonic acid metabolism: A review , 2018, Journal of advanced research.

[4]  F. Farzadfar,et al.  Obesity-Related Metabolomic Profiles and Discrimination of Metabolically Unhealthy Obesity. , 2018, Journal of proteome research.

[5]  David L Duffy,et al.  Classifying dermoscopic patterns of naevi in a case-control study of melanoma , 2017, PloS one.

[6]  A. Malinovsky Reason for indispensability of threonine in humans and other mammals in comparative aspect , 2017, Biochemistry (Moscow).

[7]  Xiuying Wang,et al.  Therapeutic Potential of Amino Acids in Inflammatory Bowel Disease , 2017, Nutrients.

[8]  D. Concordet,et al.  ASICS: an automatic method for identification and quantification of metabolites in complex 1D 1H NMR spectra , 2017, Metabolomics.

[9]  G. Genchi An overview on d-amino acids , 2017, Amino Acids.

[10]  B. Tardy,et al.  Charge tunable thin-film composite membranes by gamma-ray triggered surface polymerization , 2017, Scientific Reports.

[11]  J. Dicksved,et al.  The urine metabolome differs between lean and overweight Labrador Retriever dogs during a feed-challenge , 2017, PloS one.

[12]  J. Berthelsen,et al.  A novel BLK-induced tumor model , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[13]  Timothy J. Garrett,et al.  Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes , 2017, Scientific Reports.

[14]  J. Steiner,et al.  Diagnostic performance of the urinary canine calgranulins in dogs with lower urinary or urogenital tract carcinoma , 2017, BMC Veterinary Research.

[15]  Y. F. Cheng,et al.  Effects of threonine supplementation on the growth performance, immunity, oxidative status, intestinal integrity, and barrier function of broilers at the early age , 2017, Poultry science.

[16]  Hajk-Georg Drost,et al.  Biomartr: genomic data retrieval with R , 2017, Bioinform..

[17]  D. Allaway,et al.  Ultra high performance liquid chromatography–high resolution mass spectrometry plasma lipidomics can distinguish between canine breeds despite uncontrolled environmental variability and non-standardized diets , 2017, Metabolomics.

[18]  B. Warscheid,et al.  A systems study reveals concurrent activation of AMPK and mTOR by amino acids , 2016, Nature Communications.

[19]  H. Lohi,et al.  A non-targeted metabolite profiling pilot study suggests that tryptophan and lipid metabolisms are linked with ADHD-like behaviours in dogs , 2016, Behavioral and Brain Functions.

[20]  Adam Auton,et al.  A Pedigree-Based Map of Recombination in the Domestic Dog Genome , 2016, G3: Genes, Genomes, Genetics.

[21]  Alessandra Pedrocchi,et al.  Effects of ACL Reconstructive Surgery on Temporal Variations of Cytokine Levels in Synovial Fluid , 2016, Mediators of inflammation.

[22]  M. Petri,et al.  Inverse Relationship of the CMKLR1 Relative Expression and Chemerin Serum Levels in Obesity with Dysmetabolic Phenotype and Insulin Resistance , 2016, Mediators of inflammation.

[23]  Xiangpei Li,et al.  Association of FAM167A-BLK rs2736340 Polymorphism with Susceptibility to Autoimmune Diseases: A Meta-Analysis , 2016, Immunological investigations.

[24]  Yun Liu,et al.  Genetic risk of TNFSF4 and FAM167A-BLK polymorphisms in children with asthma and allergic rhinitis in a Han Chinese population , 2016, The Journal of asthma : official journal of the Association for the Care of Asthma.

[25]  Y. H. Lee,et al.  Association between BLK polymorphisms and susceptibility to SLE , 2016, Zeitschrift für Rheumatologie.

[26]  M. Pirinen,et al.  Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA , 2016, Nature Communications.

[27]  D. Allaway,et al.  Characterisation of the main drivers of intra- and inter- breed variability in the plasma metabolome of dogs , 2016, Metabolomics.

[28]  H. Lohi,et al.  Non-targeted metabolite profiling reveals changes in oxidative stress, tryptophan and lipid metabolisms in fearful dogs , 2016, Behavioral and Brain Functions.

[29]  A. Boyko,et al.  Genetic Mapping of Novel Loci Affecting Canine Blood Phenotypes , 2015, PloS one.

[30]  Annette Lee,et al.  Autoimmune Disease–Associated Haplotypes of BLK Exhibit Lowered Thresholds for B Cell Activation and Expansion of Ig Class‐Switched B Cells , 2015, Arthritis & rheumatology.

[31]  U. Roessner,et al.  Quantitative profiling of polar primary metabolites of two chickpea cultivars with contrasting responses to salinity. , 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[32]  Takashi Mori,et al.  Profiling of plasma metabolites in canine oral melanoma using gas chromatography-mass spectrometry , 2015, The Journal of veterinary medical science.

[33]  Ryan D. Morin,et al.  Genetic inactivation of TRAF3 in canine and human B-cell lymphoma. , 2015, Blood.

[34]  P. Williamson,et al.  Visualization of Genome Diversity in German Shepherd Dogs , 2015, Bioinformatics and biology insights.

[35]  K. Richards,et al.  Man's best friend: what can pet dogs teach us about non‐Hodgkin's lymphoma? , 2015, Immunological reviews.

[36]  S. Hatoya,et al.  Profiling of Serum Metabolites in Canine Lymphoma Using Gas Chromatography Mass Spectrometry , 2014, The Journal of veterinary medical science.

[37]  Yuzhen Tong,et al.  The MTMR9 rs2293855 polymorphism is associated with glucose tolerance, insulin secretion, insulin sensitivity and increased risk of prediabetes. , 2014, Gene.

[38]  Stephen D. Turner,et al.  qqman: an R package for visualizing GWAS results using Q-Q and manhattan plots , 2014, bioRxiv.

[39]  S. Chanock,et al.  GWAS is going to the dogs , 2014, Genome Biology.

[40]  S. Holden,et al.  Status of selected nutrients in obese dogs undergoing caloric restriction , 2013, BMC Veterinary Research.

[41]  P. Scales,et al.  A quantitative analysis of microalgal lipids for optimization of biodiesel and omega‐3 production , 2013, Biotechnology and bioengineering.

[42]  C. Field,et al.  The immune modifying effects of amino acids on gut-associated lymphoid tissue , 2013, Journal of Animal Science and Biotechnology.

[43]  H. O. de la Iglesia,et al.  Loss of the SV2-like Protein SVOP Produces No Apparent Deficits in Laboratory Mice , 2013, PloS one.

[44]  R. Vasan,et al.  A genome-wide association study of the human metabolome in a community-based cohort. , 2013, Cell metabolism.

[45]  H. Hansson-Hamlin,et al.  Disease patterns in 32,486 insured German shepherd dogs in Sweden: 1995–2006 , 2013, The Veterinary Record.

[46]  J. Nicholson,et al.  Metabolic phenotype modulation by caloric restriction in a lifelong dog study. , 2013, Journal of proteome research.

[47]  D. Allaway,et al.  Effects of dietary glucose supplementation on the fasted plasma metabolome in cats and dogs , 2013, Metabolomics.

[48]  D. Raftery,et al.  NMR-based metabolomics study of canine bladder cancer. , 2012, Biochimica et biophysica acta.

[49]  E. Ostrander,et al.  So many doggone traits: mapping genetics of multiple phenotypes in the domestic dog. , 2012, Human molecular genetics.

[50]  J. Jeon,et al.  Chemerin levels are positively correlated with abdominal visceral fat accumulation , 2012, Clinical endocrinology.

[51]  Yong Wang,et al.  Influence of BLK polymorphisms on the risk of rheumatoid arthritis , 2012, Molecular Biology Reports.

[52]  Ivan Biaggio,et al.  1,1‐Dicyano‐4‐[4‐(diethylamino)phenyl]buta‐1,3‐dienes: Structure–Property Relationships , 2012 .

[53]  Jerzy Adamski,et al.  Genome-wide association studies with metabolomics , 2012, Genome Medicine.

[54]  Paul Thompson,et al.  Phospholipids and insulin resistance in psychosis: a lipidomics study of twin pairs discordant for schizophrenia , 2012, Genome Medicine.

[55]  H. Parker Genomic analyses of modern dog breeds , 2012, Mammalian Genome.

[56]  E. Ostrander,et al.  Genome-wide association studies for multiple diseases of the German Shepherd Dog , 2011, Mammalian Genome.

[57]  D. Allaway,et al.  Identification of intra- and inter-individual metabolite variation in plasma metabolite profiles of cats and dogs. , 2011, The British journal of nutrition.

[58]  K. Lindblad-Toh,et al.  Identification of Genomic Regions Associated with Phenotypic Variation between Dog Breeds using Selection Mapping , 2011, PLoS genetics.

[59]  Jairus Bowne,et al.  Comprehensive profiling and quantitation of amine group containing metabolites. , 2011, Analytical chemistry.

[60]  D. Werling,et al.  Canine breeds at high risk of developing inflammatory bowel disease in the south-eastern UK , 2011, Veterinary Record.

[61]  Ulrich Bodenhofer,et al.  APCluster: an R package for affinity propagation clustering , 2011, Bioinform..

[62]  C. E. Alvarez,et al.  Dog models of naturally occurring cancer. , 2011, Trends in molecular medicine.

[63]  Guoyao Wu,et al.  Proline and hydroxyproline metabolism: implications for animal and human nutrition , 2011, Amino Acids.

[64]  P. Visscher,et al.  GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.

[65]  L. Gomes,et al.  Obesity Affects Collagen Fibril Diameter and Mechanical Properties of Tendons in Zucker Rats , 2010, Connective tissue research.

[66]  Paul G. Jones,et al.  Metabolite fingerprinting of urine suggests breed-specific dietary metabolism differences in domestic dogs , 2009, British Journal of Nutrition.

[67]  P. McGreevy,et al.  Inherited defects in pedigree dogs. Part 1: disorders related to breed standards. , 2009, Veterinary journal.

[68]  E. Birney,et al.  Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt , 2009, Nature Protocols.

[69]  C. Geisler,et al.  Ectopic expression of B-lymphoid kinase in cutaneous T-cell lymphoma. , 2009, Blood.

[70]  Sung Woo Kim,et al.  Arginine metabolism and nutrition in growth, health and disease , 2009, Amino Acids.

[71]  D. Breuillé,et al.  Intestinal inflammation increases gastrointestinal threonine uptake and mucin synthesis in enterally fed minipigs. , 2009, The Journal of nutrition.

[72]  K. Murphy,et al.  A review of hereditary diseases of the German shepherd dog , 2008 .

[73]  Christian Gieger,et al.  Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum , 2008, PLoS genetics.

[74]  N. Nakamura,et al.  Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane. , 2008, Molecular biology of the cell.

[75]  J. Modiano,et al.  Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans – man and his best friend share more than companionship , 2008, Chromosome Research.

[76]  Marilyn N. Martinez,et al.  Pharmacogenetic and Metabolic Differences Between Dog Breeds: Their Impact on Canine Medicine and the Use of the Dog as a Preclinical Animal Model , 2008, The AAPS Journal.

[77]  Yusuke Nakamura,et al.  Association of single-nucleotide polymorphisms in MTMR9 gene with obesity. , 2007, Human molecular genetics.

[78]  Mark R. Viant,et al.  Validation of a urine metabolome fingerprint in dog for phenotypic classification , 2007, Metabolomics.

[79]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[80]  M. Endo,et al.  LIM Kinase and Slingshot Are Critical for Neurite Extension* , 2007, Journal of Biological Chemistry.

[81]  A. D’Aniello d-Aspartic acid: An endogenous amino acid with an important neuroendocrine role , 2007, Brain Research Reviews.

[82]  S. Qiao,et al.  Effects of graded levels of true ileal digestible threonine on performance, serum parameters and immune function of 10–25 kg pigs , 2006 .

[83]  James A. Cuff,et al.  Genome sequence, comparative analysis and haplotype structure of the domestic dog , 2005, Nature.

[84]  C. Palm,et al.  Preferred stereoselective brain uptake of d-serine--a modulator of glutamatergic neurotransmission. , 2005, Nuclear medicine and biology.

[85]  B. Moor,et al.  BioMart and Bioconductor: a powerful link between biological databases and microarray data analysis , 2005, Bioinform..

[86]  S. Marangoni,et al.  Biochemical and Biomechanical Analysis of Tendons of Caged and Penned Chickens , 2004, Connective tissue research.

[87]  T. Uemura,et al.  Cell Cycle-associated Changes in Slingshot Phosphatase Activity and Roles in Cytokinesis in Animal Cells* , 2003, Journal of Biological Chemistry.

[88]  Alasdair J Edgar,et al.  The human L-threonine 3-dehydrogenase gene is an expressed pseudogene , 2002, BMC Genetics.

[89]  H. Molina,et al.  The murine complement regulator Crry: new insights into the immunobiology of complement regulation , 2002, Cellular and Molecular Life Sciences CMLS.

[90]  W. Thomson,et al.  Dog MHC alleles containing the human RA shared epitope confer susceptibility to canine rheumatoid arthritis , 2001, Immunogenetics.

[91]  A. Corfield,et al.  Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease , 2000, Gut.

[92]  T. Takano,et al.  Complement C5b-9-mediated arachidonic acid metabolism in glomerular epithelial cells : role of cyclooxygenase-1 and -2. , 2000, The American journal of pathology.

[93]  P. Thacker,et al.  Effects of dietary threonine on performance, plasma parameters and immune function of growing pigs , 1999 .

[94]  S. Johnson,et al.  l-Arginine potentiates GABA-mediated synaptic transmission by a nitric oxide-independent mechanism in rat dopamine neurons , 1997, Neuroscience.

[95]  R. Freedland,et al.  Threonine is catabolized by L-threonine 3-dehydrogenase and threonine dehydratase in hepatocytes from domestic cats (Felis domestica). , 1996, The Journal of nutrition.

[96]  S. Moncada,et al.  The L-arginine-nitric oxide pathway. , 1993, The New England journal of medicine.

[97]  L. Petrucelli,et al.  Further study on the specificity of D-amino acid oxidase and D-aspartate oxidase and time course for complete oxidation of D-amino acids. , 1993, Comparative biochemistry and physiology. B, Comparative biochemistry.

[98]  C. Demigné,et al.  Influence of glucogenic amino acids on the hepatic metabolism of threonine. , 1992, Biochimica et biophysica acta.

[99]  G. Lobley,et al.  Quantitative partition of threonine oxidation in pigs: effect of dietary threonine. , 1990, The American journal of physiology.

[100]  P. Nunn,et al.  Metabolic homoeostasis of L-threonine in the normally-fed rat. Importance of liver threonine dehydrogenase activity. , 1983, The Biochemical journal.

[101]  R. Burns,et al.  Threonine, tryptophan and histidine requirements of immature beagle dogs. , 1982, The Journal of nutrition.

[102]  J. Milner,et al.  Arginine: an indispensable amino acid for mature dogs. , 1981, The Journal of nutrition.

[103]  B. Weksler,et al.  Human complement in the arachidonic acid transformation pathway in platelets , 1981, The Journal of experimental medicine.

[104]  J. Milner,et al.  Assessment of the essentiality of methionine, threonine, tryptophan, histidine and isoleucine in immature dogs. , 1979, The Journal of nutrition.

[105]  T. Lumley,et al.  gplots: Various R Programming Tools for Plotting Data , 2015 .

[106]  R. Wellard,et al.  The use of metabolomics to monitor simultaneous changes in metabolic variables following supramaximal low volume high intensity exercise , 2015, Metabolomics.

[107]  X. Mao,et al.  Specific roles of threonine in intestinal mucosal integrity and barrier function. , 2011, Frontiers in bioscience.

[108]  P. McGreevy,et al.  Inherited defects in pedigree dogs. Part 2: Disorders that are not related to breed standards. , 2010, Veterinary journal.

[109]  S. Bae,et al.  1 30-Inch Roll-Based Production of High-Quality Graphene Films for Flexible Transparent Electrodes , 2009 .

[110]  U. Günther,et al.  Validation of a urine metabolome fingerprint in dog for phenotypic classification , 2007, Metabolomics.

[111]  O. Fiehn Metabolomics – the link between genotypes and phenotypes , 2004, Plant Molecular Biology.

[112]  B. Samuelsson Arachidonic acid metabolism: role in inflammation. , 1991, Zeitschrift fur Rheumatologie.

[113]  P. Fürst,et al.  Plasma amino acids in rheumatoid arthritis. , 1985, Scandinavian journal of rheumatology.