CCL2 release by airway smooth muscle is increased in asthma and promotes fibrocyte migration

Asthma is characterized by variable airflow obstruction, airway inflammation, airway hyper‐responsiveness and airway remodelling. Airway smooth muscle (ASM) hyperplasia is a feature of airway remodelling and contributes to bronchial wall thickening. We sought to investigate the expression levels of chemokines in primary cultures of ASM cells from asthmatics vs healthy controls and to assess whether differentially expressed chemokines (i) promote fibrocyte (FC) migration towards ASM and (ii) are increased in blood from subjects with asthma and in sputum samples from those asthmatics with bronchial wall thickening.

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[43]  René M. Roy,et al.  Chitin Elicits CCL2 from Airway Epithelial Cells and Induces CCR2-Dependent Innate Allergic Inflammation in the Lung , 2012, The Journal of Immunology.

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[45]  L. Murray,et al.  Chemokine (C-C motif) ligand 2 mediates direct and indirect fibrotic responses in human and murine cultured fibrocytes , 2011, Fibrogenesis & tissue repair.

[46]  I. Pavord,et al.  Qualitative analysis of high-resolution CT scans in severe asthma. , 2009, Chest.

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[52]  C. Brightling,et al.  Mast Cells Promote Airway Smooth Muscle Cell Differentiation via Autocrine Up-Regulation of TGF-β11 , 2008, The Journal of Immunology.

[53]  K. Chung,et al.  Increased circulating fibrocytes in asthma with chronic airflow obstruction. , 2008, American journal of respiratory and critical care medicine.

[54]  C. Brightling,et al.  Human Airway Smooth Muscle Promotes Human Lung Mast Cell Survival, Proliferation, and Constitutive Activation: Cooperative Roles for CADM1, Stem Cell Factor, and IL-61 , 2008, The Journal of Immunology.

[55]  C. Brightling,et al.  Airway smooth muscle and mast cell-derived CC chemokine ligand 19 mediate airway smooth muscle migration in asthma. , 2006, American journal of respiratory and critical care medicine.

[56]  Christopher E Brightling,et al.  Cooperative molecular and cellular networks regulate Toll‐like receptor‐dependent inflammatory responses , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[57]  S. Braman.  The global burden of asthma. , 2006, Chest.

[58]  C. Brightling,et al.  The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle. , 2005, American journal of respiratory and critical care medicine.

[59]  Klas Svensson,et al.  Measurement properties and interpretation of three shortened versions of the asthma control questionnaire. , 2005, Respiratory medicine.

[60]  A. Knox,et al.  Differential regulation of chemokine expression by peroxisome proliferator-activated receptor gamma agonists: interactions with glucocorticoids and beta2-agonists. , 2005, The Journal of biological chemistry.

[61]  M. Burdick,et al.  Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. , 2004, The Journal of clinical investigation.

[62]  S. Sung,et al.  Significant Involvement of CCL2 (MCP‐1) in Inflammatory Disorders of the Lung , 2003, Microcirculation.

[63]  M. Aubier,et al.  Airway structural alterations selectively associated with severe asthma. , 2003, American journal of respiratory and critical care medicine.

[64]  R. Panettieri.  Airway smooth muscle: an immunomodulatory cell. , 2002, The Journal of allergy and clinical immunology.

[65]  I. Pavord,et al.  Mast-cell infiltration of airway smooth muscle in asthma. , 2002, The New England journal of medicine.

[66]  M. Grunstein,et al.  Regulation of TH1- and TH2-type cytokine expression and action in atopic asthmatic sensitized airway smooth muscle. , 1999, The Journal of clinical investigation.

[67]  C. Martínez-A,et al.  The Coordinated Action of CC Chemokines in the Lung Orchestrates Allergic Inflammation and Airway Hyperresponsiveness , 1998, The Journal of experimental medicine.

[68]  J. Westwick,et al.  Interleukin 8 and monocyte chemoattractant protein 1 production by cultured human airway smooth muscle cells. , 1998, Cytokine.

[69]  S. Holgate,et al.  Release of RANTES, MIP-1 alpha, and MCP-1 into asthmatic airways following endobronchial allergen challenge. , 1997, American journal of respiratory and critical care medicine.

[70]  I. Pavord,et al.  The use of induced sputum to investigate airway inflammation. , 1997, Thorax.

[71]  A. Sousa,et al.  Increased expression of the monocyte chemoattractant protein-1 in bronchial tissue from asthmatic subjects. , 1994, American journal of respiratory cell and molecular biology.

[72]  A. Mantovani,et al.  Divergent effects of interleukin‐10 on cytokine production by mononuclear phagocytes and endothelial cells , 1993, European journal of immunology.

[73]  J. Hogg,et al.  Functional significance of increased airway smooth muscle in asthma and COPD. , 1993, Journal of applied physiology.

[74]  E. Leonard,et al.  Biological aspects of monocyte chemoattractant protein-1 (MCP-1). , 1991, Advances in Experimental Medicine and Biology.