Alzheimer's disease with abnormal cerebrospinal fluid flow

W A b n o r n i a l i t i e s of v e n t r i c u l a r s izc have l o n g been k n o w n to o c c u r i n d e n i e n t e d pa t ien ts . E v e r s i n c e the ini t ia l r e p o r t by Adanls. Fisher a n d H a k i n i ' o f p a t i e n t s w i t h occu l t h y d r o c e p h a l u s , it c lear ly has b e e n i m p o r t a n t t o d is t inguish d e m e n t e d p a t i e n t s w i t h c e r e b r a l a t r o p h y f r o m those wi th p r i m a r y a b n o r niii I it ies o f c e r e b r o s p i n a l f lu id (CSF) f low. V a r i o u s c r i te r ia have b e e n p r o p o s e d t o d i f fe ren t ia te these t w o groups o f pa t ien ts , b u t the d is t inct ion is n o t a l w a y s eas i ly made. T h i s r e p o r t d e s c r i b e s ii p a t i e n t w i t h t h e t y p i c a l r a d i o g r a p h i c ;md c i s t e r n n g r a p h i c f ind ings of o c c u l t h y d r o c e p h a l u s . T h e pa t ien t had the m a r k e d p a t h o l o g i c c h a n g e s t y p i c a l o f Alzhe imer ' s d i sease tha t a r e i n t e r p r e t e d a s having caused t h e a b n o r m a l i t i e s o f CSF f l o w .