p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers.
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J. Cheville | B. Scheithauer | L. Jin | X. Qian | R. Lloyd | E. Kulig | L. Erickson
[1] P. Wollan,et al. Parathyroid hyperplasia, adenomas, and carcinomas: differential expression of p27Kip1 protein. , 1999, The American journal of surgical pathology.
[2] C. Cordon-Cardo,et al. Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma. , 1999, Journal of the National Cancer Institute.
[3] James M. Roberts,et al. The murine gene p27Kip1 is haplo-insufficient for tumour suppression , 1998, Nature.
[4] L. Jin,et al. DNA methylation regulates p27kip1 expression in rodent pituitary cell lines. , 1998, The American journal of pathology.
[5] V. Godfrey,et al. CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. , 1998, Genes & development.
[6] M. Loda,et al. Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases. , 1998, The American journal of pathology.
[7] I. Weinstein,et al. Overexpression of p27Kip1 inhibits the growth of both normal and transformed human mammary epithelial cells. , 1998, Cancer research.
[8] M. Kitagawa,et al. Role of p27Kip1 and cyclin-dependent kinase 2 in the proliferation of non-small cell lung cancer. , 1998, The American journal of pathology.
[9] Robert S. Kerbel,et al. E-Cadherin–dependent Growth Suppression is Mediated by the Cyclin-dependent Kinase Inhibitor p27KIP1 , 1998, The Journal of cell biology.
[10] E. Campo,et al. Mantle cell lymphomas lack expression of p27Kip1, a cyclin-dependent kinase inhibitor. , 1998, The American journal of pathology.
[11] J. Nesland,et al. Protein expression of the cell-cycle inhibitor p27Kip1 in malignant melanoma: inverse correlation with disease-free survival. , 1998, The American journal of pathology.
[12] J. Richards,et al. Hormone-induced proliferation and differentiation of granulosa cells: a coordinated balance of the cell cycle regulators cyclin D2 and p27Kip1. , 1998, Molecular endocrinology.
[13] E. Levin,et al. Astrocyte Progression from G1 to S Phase of the Cell Cycle Depends upon Multiple Protein Interaction* , 1998, The Journal of Biological Chemistry.
[14] R. Weinberg,et al. The Expanding Role of Cell Cycle Regulators , 1998, Science.
[15] James M. Roberts,et al. The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury , 1998, Nature Medicine.
[16] M. Loda,et al. Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma. , 1998, Cancer research.
[17] J. Cheville,et al. Expression of p27kip1 in prostatic adenocarcinoma. , 1998, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
[18] L. Jin,et al. Expression of D-type cyclins in normal and neoplastic rat pituitary. , 1998, Endocrinology.
[19] M. Kaplan,et al. Stat Proteins Control Lymphocyte Proliferation by Regulating p27Kip1 Expression , 1998, Molecular and Cellular Biology.
[20] S. Melmed,et al. Molecular characterization of the men1 tumor suppressor gene in sporadic pituitary tumors. , 1998, The Journal of clinical endocrinology and metabolism.
[21] M. Loda,et al. Low p27 expression predicts poor disease-free survival in patients with prostate cancer. , 1998, The Journal of urology.
[22] Y. Yatabe,et al. p27KIP1 in human lung cancers: differential changes in small cell and non-small cell carcinomas. , 1998, Cancer research.
[23] James M. Roberts,et al. Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade. , 1998, Molecular cell.
[24] M. Roussel,et al. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1). , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[25] L. Klotz,et al. Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma. , 1998, Cancer research.
[26] G. Bradley,et al. Reduced levels of the cell-cycle inhibitor p27Kip1 in epithelial dysplasia and carcinoma of the oral cavity. , 1998, The American journal of pathology.
[27] P. Wollan,et al. Expression of p27kip1 and Ki-67 in benign and malignant thyroid tumors. , 1998, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.
[28] R. Aguiar,et al. Mutation and expression analysis of the p27/kip1 gene in corticotrophin-secreting tumours , 1998, Oncogene.
[29] P. Seth,et al. Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27. , 1997, Cancer research.
[30] M. Nakanishi,et al. Cell cycle-dependent phosphorylation of p27 cyclin-dependent kinase (Cdk) inhibitor by cyclin E/Cdk2. , 1997, Biochemical and biophysical research communications.
[31] R. Deshaies,et al. A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p , 1997, Cell.
[32] Y. Doki,et al. Deregulated expression of p27(Kip1) in human breast cancers. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.
[33] N. Takuwa,et al. Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts , 1997, Molecular and cellular biology.
[34] T. Sano,et al. Infrequent mutations of p27Kip1 gene and trisomy 12 in a subset of human pituitary adenomas. , 1997, The Journal of clinical endocrinology and metabolism.
[35] Bruno Amati,et al. Phosphorylation‐dependent degradation of the cyclin‐dependent kinase inhibitor p27Kip1 , 1997, The EMBO journal.
[36] A. Üren,et al. Carboxyl-terminal Domain of p27Kip1 Activates CDC2* , 1997, The Journal of Biological Chemistry.
[37] Esposito,et al. Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer. , 1997, Cancer research.
[38] B. Scheithauer,et al. Transforming growth factor-beta, transforming growth factor-beta receptor II, and p27Kip1 expression in nontumorous and neoplastic human pituitaries. , 1997, The American journal of pathology.
[39] K. Post,et al. Frequent inactivation of the p16 gene in human pituitary tumors by gene methylation , 1997, Molecular carcinogenesis.
[40] M. Kerin. Cancer principles and practice of oncology , 1997 .
[41] K. Mimori,et al. p27 expression and gastric carcinoma , 1997, Nature Medicine.
[42] M. Piris,et al. Cyclin-dependent kinase inhibitor p27KIP1 in lymphoid tissue: p27KIP1 expression is inversely proportional to the proliferative index. , 1997, The American journal of pathology.
[43] S. Shousha,et al. High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[44] S. Melmed,et al. Genetic basis of endocrine disease: pituitary tumor pathogenesis. , 1997, The Journal of clinical endocrinology and metabolism.
[45] James M. Roberts,et al. Cyclin E-CDK2 is a regulator of p27Kip1. , 1997, Genes & development.
[46] S. Melmed,et al. Pituitary Tumor Pathogenesis1 , 1997 .
[47] P. Heikkilä,et al. Ribonucleic acid expression of the clustered imprinted genes, p57KIP2, insulin-like growth factor II, and H19, in adrenal tumors and cultured adrenal cells. , 1997, The Journal of clinical endocrinology and metabolism.
[48] S. Elledge,et al. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome , 1997, Nature.
[49] K. Hruska,et al. Expression of p27Kip1 in osteoblast-like cells during differentiation with parathyroid hormone. , 1997, Endocrinology.
[50] M. Loda,et al. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. , 1997, Cancer research.
[51] M. Pagano,et al. Enhanced Ribosomal Association of p27Kip1 mRNA Is a Mechanism Contributing to Accumulation during Growth Arrest* , 1997, The Journal of Biological Chemistry.
[52] M. Pagano,et al. Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation , 1997, Leukemia.
[53] M. Loda,et al. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas , 1997, Nature Medicine.
[54] P. Steeg,et al. Cancer prognostics: Past, present and p27 , 1997, Nature Medicine.
[55] L. Jin,et al. Aberrant p27kip1 expression in endocrine and other tumors. , 1997, The American journal of pathology.
[56] Herman Yeger,et al. Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer , 1997, Nature Medicine.
[57] James M. Roberts,et al. Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients , 1997, Nature Medicine.
[58] M. Raff,et al. Accumulation of the cyclin‐dependent kinase inhibitor p27/Kip1 and the timing of oligodendrocyte differentiation , 1997, The EMBO journal.
[59] C. Sherr. Cancer Cell Cycles , 1996, Science.
[60] B. Amati,et al. Growth arrest by the cyclin‐dependent kinase inhibitor p27Kip1 is abrogated by c‐Myc. , 1996, The EMBO journal.
[61] R. Kerbel,et al. Impact of the cyclin–dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents , 1996, Nature Medicine.
[62] T. Hunt,et al. The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase. , 1996, The EMBO journal.
[63] Philip D. Jeffrey,et al. Crystal structure of the p27Kip1 cyclin-dependent-kinase inibitor bound to the cyclin A–Cdk2 complex , 1996, Nature.
[64] L. Jin,et al. Transforming growth factor-beta and p27 expression in pituitary cells. , 1996, Endocrinology.
[65] K. Post,et al. Frequent loss of the P16INK4a gene product in human pituitary tumors. , 1996, Cancer research.
[66] James M. Roberts,et al. A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27 Kip1 -Deficient Mice , 1996, Cell.
[67] K. Manova-Todorova,et al. Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27 Kip1 , 1996, Cell.
[68] Nobuyuki Shishido,et al. Mice Lacking p27 Kip1 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors , 1996, Cell.
[69] H. Koeffler,et al. p27/Kip1 mutation found in breast cancer. , 1996, Cancer research.
[70] James M. Roberts,et al. Requirement of p27Kip1 for Restriction Point Control of the Fibroblast Cell Cycle , 1996, Science.
[71] M. Shuford,et al. Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin-dependent kinase inhibitor p27KIP1. , 1996, The Journal of clinical investigation.
[72] L. Hengst,et al. Translational Control of p27Kip1 Accumulation During the Cell Cycle , 1996, Science.
[73] T. Hunter,et al. Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFβ-treated cells , 1996, Nature.
[74] A. deFazio,et al. Antiestrogen inhibition of cell cycle progression in breast cancer cells in associated with inhibition of cyclin-dependent kinase activity and decreased retinoblastoma protein phosphorylation. , 1995, Molecular endocrinology.
[75] B. Clurman,et al. Cell cycle and cancer. , 1995, Journal of the National Cancer Institute.
[76] M. Tomonaga,et al. Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma. , 1995, Blood.
[77] T. Hunter,et al. Redistribution of the CDK inhibitor p27 between different cyclin.CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. , 1995, Molecular biology of the cell.
[78] P. Beer-Romero,et al. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. , 1995, Science.
[79] X. Bertagna,et al. Recent advances in the pathogenesis of adrenocortical tumours. , 1995, European journal of endocrinology.
[80] H. Koeffler,et al. Role of the cyclin-dependent kinase inhibitors in the development of cancer. , 1995, Blood.
[81] J. Roth,et al. Cell cycle arrest and inhibition of tumor cell proliferation by the p16INK4 gene mediated by an adenovirus vector. , 1995, Cancer research.
[82] F. Haluska,et al. Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression. , 1995, Cancer research.
[83] S. Nagataki,et al. Radiation-induced G1 arrest is selectively mediated by the p53-WAF1/Cip1 pathway in human thyroid cells. , 1995, Cancer research.
[84] James M. Roberts,et al. Inhibitors of mammalian G1 cyclin-dependent kinases. , 1995, Genes & development.
[85] D N Shapiro,et al. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4 , 1995, Molecular and cellular biology.
[86] M. Roussel,et al. Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6 , 1995, Molecular and cellular biology.
[87] A. Goldberg. Functions of the proteasome: the lysis at the end of the tunnel. , 1995, Science.
[88] A. Kamb,et al. Cell-cycle regulators and cancer. , 1995, Trends in genetics : TIG.
[89] M. J. Ravitz,et al. Transforming growth factor beta-induced activation of cyclin E-cdk2 kinase and down-regulation of p27Kip1 in C3H 10T1/2 mouse fibroblasts. , 1995, Cancer research.
[90] S. Elledge,et al. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. , 1995, Genes & development.
[91] J. Massagué,et al. Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. , 1995, Genes & development.
[92] J. Massagué,et al. p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors. , 1995, Cancer research.
[93] G. Hannon,et al. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD , 1995, Science.
[94] J. Massagué,et al. Mammalian antiproliferative signals and their targets. , 1995, Current opinion in genetics & development.
[95] C. O'keefe,et al. Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. , 1994, Genes & development.
[96] James M. Roberts,et al. lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin , 1994, Nature.
[97] T. Hunter,et al. Cyclins and cancer II: Cyclin D and CDK inhibitors come of age , 1994, Cell.
[98] C. Sherr. G1 phase progression: Cycling on cue , 1994, Cell.
[99] J. Massagué,et al. Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27 Kip1 ) of cyclin-dependent kinase 4 activation , 1994, Cell.
[100] James M. Roberts,et al. Cloning of p27 Kip1 , a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals , 1994, Cell.
[101] Tony Hunter,et al. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21 , 1994, Cell.
[102] J. Roberts,et al. Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes , 1994, Molecular and cellular biology.
[103] L. Hengst,et al. A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells , 1994, Molecular and cellular biology.
[104] M. Zou,et al. Molecular basis of thyroid cancer. , 1994, Endocrine reviews.
[105] A. Arnold. Molecular mechanisms of parathyroid neoplasia. , 1994, Endocrinology and metabolism clinics of North America.
[106] David Beach,et al. p21 is a universal inhibitor of cyclin kinases , 1993, Nature.
[107] J. Trent,et al. WAF1, a potential mediator of p53 tumor suppression , 1993, Cell.
[108] A. Arnold. Genetic basis of endocrine disease 5. Molecular genetics of parathyroid gland neoplasia. , 1993, The Journal of clinical endocrinology and metabolism.
[109] James M. Roberts,et al. Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta. , 1993, Science.
[110] J. Fagin. Genetic basis of endocrine disease 3: Molecular defects in thyroid gland neoplasia. , 1992, The Journal of clinical endocrinology and metabolism.
[111] James M. Roberts,et al. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle , 1992 .
[112] I. Doniach. Functional Endocrine Pathology , 1991 .
[113] R. Eddy,et al. Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma. , 1989, The Journal of clinical investigation.
[114] Craig R Moores,et al. H-40, an antigen controlled by an Igh linked gene and recognized by cytotoxic T lymphocytes. I. Genetic analysis of H-40 and distribution of its product on B cell tumors , 1984, The Journal of experimental medicine.
[115] J. Herman,et al. Alterations in DNA methylation: a fundamental aspect of neoplasia. , 1998, Advances in cancer research.
[116] B. Wold,et al. p27Kip1 is expressed transiently in developing myotomes and enhances myogenesis. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[117] G. Cattoretti,et al. Localization and expression of p27KIP1 in multistage colorectal carcinogenesis. , 1998, Cancer research.
[118] R. Lloyd,et al. TGFβ, TGFβ receptors, Ki-67, and p27Kip1 expression in papillary thyroid carcinomas , 1997 .
[119] W. Farrell,et al. Tumour suppressor genes in the pathogenesis of human pituitary tumours. , 1997, Hormone research.
[120] C. Larsson,et al. Alterations of p53 and expression of WAF1/p21 in human thyroid tumors. , 1996, Thyroid : official journal of the American Thyroid Association.
[121] M. Hochstrasser. Ubiquitin, proteasomes, and the regulation of intracellular protein degradation. , 1995, Current opinion in cell biology.
[122] James M. Roberts,et al. p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. , 1994, Genes & development.
[123] V. Devita,et al. Cancer : Principles and Practice of Oncology , 1982 .
[124] D. Rubin,et al. The proteasome : a protein-degrading organelle ? , 2022 .