Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis

Tumor metastasis is a major factor for poor prognosis of hepatocellular carcinoma (HCC), but the relationship between ubiquitination and metastasis need to be studied more systematically. We analyzed the ubiquitinome of HCC in this study to have a more comprehensive insight into human HCC metastasis.

[1]  Zhikun Liu,et al.  Molecular subtyping of hepatocellular carcinoma: A step toward precision medicine , 2020, Cancer communications.

[2]  Xiaolong Liu,et al.  Proteomic analyses reveal divergent ubiquitylation patterns in hepatocellula carcinoma cell lines with different metastasis potential. , 2020, Journal of proteomics.

[3]  C. Proud,et al.  Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3 , 2020, International journal of cancer.

[4]  G. Duan,et al.  E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation , 2020, Molecular and Cellular Biology.

[5]  A. Jemal,et al.  Cancer statistics, 2020 , 2020, CA: a cancer journal for clinicians.

[6]  C. Qin,et al.  The E3 ubiquitin ligase TRIM7 suppressed hepatocellular carcinoma progression by directly targeting Src protein , 2019, Cell Death & Differentiation.

[7]  C. Sander,et al.  LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer , 2019, Nature.

[8]  R. Lothe,et al.  Combination therapies with HSP90 inhibitors against colorectal cancer. , 2019, Biochimica et biophysica acta. Reviews on cancer.

[9]  C. Proud,et al.  Ablation of elongation factor 2 kinase enhances heat-shock protein 90 chaperone expression and protects cells under proteotoxic stress , 2019, The Journal of Biological Chemistry.

[10]  Zhining Fan,et al.  Upregulation of HRD1 promotes cell migration and invasion in colon cancer , 2018, Molecular and Cellular Biochemistry.

[11]  Zhaojian Liu,et al.  HRD1-mediated PTEN degradation promotes cell proliferation and hepatocellular carcinoma progression. , 2018, Cellular signalling.

[12]  Kenli Li,et al.  iProX: an integrated proteome resource , 2018, Nucleic Acids Res..

[13]  C. Proud,et al.  Eukaryotic Elongation Factor 2 Kinase (eEF2K) in Cancer , 2017, Cancers.

[14]  C. Croce,et al.  MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma , 2017, Gastroenterology.

[15]  A. Ciechanover,et al.  The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy. , 2017, Trends in biochemical sciences.

[16]  Yuki Hayashi,et al.  Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD) , 2017, Journal of Cell Science.

[17]  G. Meng,et al.  HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells , 2017, Nature Communications.

[18]  F. He,et al.  An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network , 2017, Nature Communications.

[19]  Yang Li,et al.  An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network , 2017, Nature Communications.

[20]  Cheng Li,et al.  GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses , 2017, Nucleic Acids Res..

[21]  D. Donoghue,et al.  The importance of regulatory ubiquitination in cancer and metastasis , 2017, Cell cycle.

[22]  Marco Y. Hein,et al.  The Perseus computational platform for comprehensive analysis of (prote)omics data , 2016, Nature Methods.

[23]  S. Armstrong,et al.  Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias. , 2015, Blood.

[24]  Jin-hai Tang,et al.  HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation , 2015, Oncotarget.

[25]  C. Proud,et al.  Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity. , 2015, The Biochemical journal.

[26]  Jimin Zhu,et al.  The role and therapeutic implications of RING‐finger E3 ubiquitin ligases in hepatocellular carcinoma , 2015, International journal of cancer.

[27]  Michael N. Hall,et al.  mTORC1 mediated translational elongation limits intestinal tumour initiation and growth , 2014, Nature.

[28]  M. Gleave,et al.  Suppression of heat shock protein 27 using OGX-427 induces endoplasmic reticulum stress and potentiates heat shock protein 90 inhibitors to delay castrate-resistant prostate cancer. , 2014, European urology.

[29]  C. Proud,et al.  Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles. , 2014, Advances in biological regulation.

[30]  S. Carr,et al.  Large-scale identification of ubiquitination sites by mass spectrometry , 2013, Nature Protocols.

[31]  A. Kirschning,et al.  Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy. , 2013, Natural product reports.

[32]  A. Shaw,et al.  Targeted inhibition of the molecular chaperone Hsp90 overcomes ALK inhibitor resistance in non-small cell lung cancer. , 2013, Cancer discovery.

[33]  J. Hazle,et al.  The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis , 2012, Cell.

[34]  Jian-Bing Fan,et al.  Gene-expression signature of vascular invasion in hepatocellular carcinoma. , 2011, Journal of hepatology.

[35]  J. Llovet,et al.  A system of classifying microvascular invasion to predict outcome after resection in patients with hepatocellular carcinoma. , 2009, Gastroenterology.

[36]  P. Thuluvath.  Vascular invasion is the most important predictor of survival in HCC, but how do we find it? , 2009, Journal of clinical gastroenterology.

[37]  S. Yamasaki,et al.  The Roles of Synoviolin in Crosstalk Between Endoplasmic Reticulum Stress-Induced Apoptosis and p53 Pathway , 2007, Cell cycle.

[38]  Pier Paolo Pandolfi,et al.  Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation , 2007, Nature Reviews Cancer.

[39]  Daniela Hoeller,et al.  Ubiquitin and ubiquitin-like proteins in cancer pathogenesis , 2006, Nature Reviews Cancer.

[40]  Yi Sun.  E3 ubiquitin ligases as cancer targets and biomarkers. , 2006, Neoplasia.

[41]  D. Reinberg,et al.  Histone H2B Monoubiquitination Functions Cooperatively with FACT to Regulate Elongation by RNA Polymerase II , 2006, Cell.

[42]  Sonia Arora,et al.  Identification of the ubiquitin-proteasome pathway in the regulation of the stability of eukaryotic elongation factor-2 kinase. , 2005, Cancer research.

[43]  R. Zeng,et al.  Proteome analysis of hepatocellular carcinoma cell strains, MHCC97‐H and MHCC97‐L, with different metastasis potentials , 2004, Proteomics.

[44]  M. Chung,et al.  Proteome database of hepatocellular carcinoma. , 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[45]  W. Hait,et al.  Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. , 2001, Cancer research.

[46]  A. Weissman.  Ubiquitin and proteasomes: Themes and variations on ubiquitylation , 2001, Nature Reviews Molecular Cell Biology.

[47]  A. Hershko.  Ubiquitin-mediated protein degradation. , 1988, The Journal of biological chemistry.

[48]  A. Hershko,et al.  Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation. , 1982, The Journal of biological chemistry.

[49]  A Ciechanover,et al.  ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[50]  A. Burroughs,et al.  A Systematic Review of Microvascular Invasion in Hepatocellular Carcinoma: Diagnostic and Prognostic Variability , 2012, Annals of Surgical Oncology.

[51]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[52]  Brad T. Sherman,et al.  Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists , 2008, Nucleic acids research.