Immunohistochemical study of the expression of human chorionic gonadotropin‐β in oral squamous cell carcinoma

Human chorionic gonadotropin (hCG) is a glycoprotein hormone comprised of two dissimilar subunits (α and β) and normally is synthesized by trophoblastic tissue. Although hCG expression has been identified in a variety of neoplastic tissues, to the authors' knowledge no investigation has centered on tumors of oral origin.

[1]  S. Ishiguro,et al.  KAI1/CD82 expression in nonsmall cell lung carcinoma is a novel, favorable prognostic factor , 1998, Cancer.

[2]  W. Regelson Have we found the “definitive cancer biomarker”?. The diagnostic and therapeutic implications of human chorionic gonadotropin‐beta expression as a key to malignancy , 1995, Cancer.

[3]  R. Canfield,et al.  Recent advances in the chemistry and immunochemistry of human chorionic gonadotropin: impact on clinical measurements. , 1994, Endocrine reviews.

[4]  B. Malassagne,et al.  Free Human Chorionic Gonadotropin β Subunit in Gonadal and Nongonadal Neoplasms , 1992 .

[5]  陽一 矢毛石 Distribution of β-human chorionic gonadotropin-positive cells in noncancerous gastric mucosa and in malignant gastric tumors , 1991 .

[6]  T. Kosaka,et al.  Human chorionic gonadotropin in colorectal cancer and its relationship to prognosis. , 1989, British Journal of Cancer.

[7]  J. Campain,et al.  Chorionic gonadotropin synthesis by human tumor cell lines: examination of subunit accumulation, steady-state levels of mRNA, and gene structure. , 1989, Biochimica et biophysica acta.

[8]  G. Braunstein,et al.  Human chorionic gonadotropin expression in lung, breast, and renal carcinomas. , 1988, Archives of pathology & laboratory medicine.

[9]  C. Harris,et al.  Immunocytochemical evaluation of human esophageal neoplasms and preneoplastic lesions for beta-chorionic gonadotropin, placental lactogen, alpha-fetoprotein, carcinoembryonic antigen, and nonspecific cross-reacting antigen. , 1986, Cancer research.

[10]  R. Bagin,et al.  Tumor marker expression in breast carcinomas and relationship to prognosis. An immunohistochemical study. , 1985, American journal of clinical pathology.

[11]  B. Gusterson,et al.  Production of β‐human chorionic gonadotrophin by human squamous carcinoma cell lines , 1985 .

[12]  M. Khazaeli,et al.  Isolated ectopic production of the free beta subunit of chorionic gonadotropin by an epidermoid carcinoma of unknown primary site , 1985, Cancer.

[13]  N. Kimura,et al.  An immunohistochemical study of keratin, carcinoembryonic antigen, human chorionic gonadotropin and alpha-fetoprotein in lung cancer. , 1985, The Tohoku journal of experimental medicine.

[14]  C. Wittekind,et al.  Immunohistological localization of β-HCG in breast carcinomas , 1984 .

[15]  E. Heyderman,et al.  Biological markers in lung cancer: an immunocytochemical approach. , 1982, Cancer detection and prevention.

[16]  B. Trump,et al.  Elaboration of human chorionic gonadotropin by lung tumors: an immunocytochemical study. , 1981, Archives of pathology & laboratory medicine.

[17]  J. Arrang,et al.  Localization of the β subunit of human chorionic gonadotrophin on various tumors , 1980 .

[18]  W. Fishman,et al.  EXPRESSION OF ONCODEVELOPMENTAL MARKERS (REGAN ISOZYME, β-HCG, CEA) IN TUMOR TISSUES AND UNINVOLVED BRONCHIAL MUCOSA. AN IMMUNOHISTOCHEMICAL STUDY , 1980 .

[19]  J. Uriel Retrodifferentiation and the fetal patterns of gene expression in cancer. , 1979, Advances in cancer research.

[20]  P. Fialkow,et al.  Clonal origin of human tumors. , 1979, Annual review of medicine.

[21]  H. Imura,et al.  Ectopic production of human chorionic gonadotropin in malignant tumors , 1978, Cancer.

[22]  M. Ostrander,et al.  Human chorionic gonadotrophins (hCG) in nontrophoblastic neoplasms. Assessment of abnormalities of hCG and CEA in bronchogenic and digestive neoplasms , 1976, Cancer.

[23]  L. McManus,et al.  Human chorionic gonadotropin in human neoplastic cells. , 1976, Cancer research.

[24]  G. Milne,et al.  PROGNOSTIC SIGNIFICANCE OF INAPPROPRIATE PRODUCTION OF PREGNANCY PROTEINS BY BREAST CANCERS , 1976, The Lancet.

[25]  B. Weintraub,et al.  Placental proteins and their subunits as tumor markers. , 1975, Annals of internal medicine.

[26]  G. Braunstein,et al.  Ectopic production of human chorionic gonadotrophin by neoplasms. , 1973, Annals of internal medicine.