论文信息 - Evaluation Of Genotoxicity Of Bromate Ion Produced During Ozonation

Evaluation Of Genotoxicity Of Bromate Ion Produced During Ozonation

Abstract Bromate ion formation during ozonation processes in water works is regarded as an issue of great interest because of its potential for carcinogenicity. In this research, genotoxicity of bromate ion was investigated by the umu-test using Salmonella typhimurium TA 1535/pSK1002. The time-course study showed that the umuC gene related to error-prone repair of damaged DNA was induced by bromate ion after 12 hours exposure of the test strain. However, a further study revealed that this induction was inactivated by metabolism with rat liver microsome when bromate ion concentration was less than 0.88 mg BrO3 −/mg as protein of the S9 fraction. This inactivation was assumed to depend on -SH compounds in liver microsome.

Y. Ono | S. Mohri | I. Somiya

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