Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury.

[1]  A. Koçyiğit,et al.  Synovial fluid and plasma selenium, copper, zinc, and iron concentrations in patients with rheumatoid arthritis and osteoarthritis , 2005, Biological Trace Element Research.

[2]  Alexander Zien,et al.  Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. , 2006, Arthritis and rheumatism.

[3]  N. Maeda,et al.  Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation. , 2006, Free radical biology & medicine.

[4]  A. Kasperczyk,et al.  Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint. , 2006, Osteoarthritis and cartilage.

[5]  E. Regan,et al.  Extracellular superoxide dismutase and oxidant damage in osteoarthritis. , 2005, Arthritis and rheumatism.

[6]  F. Meyskens,et al.  Redox regulation by intrinsic species and extrinsic nutrients in normal and cancer cells. , 2005, Annual review of nutrition.

[7]  Kanji Fukuda,et al.  Superoxide dismutase inhibits interleukin-1-induced degradation of human cartilage , 1994, Agents and Actions.

[8]  J. Deschner,et al.  Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals. , 2004, Arthritis and rheumatism.

[9]  J. Buckwalter,et al.  Chondrocyte Senescence, Joint Loading and Osteoarthritis , 2004, Clinical orthopaedics and related research.

[10]  L. Setton,et al.  Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model. , 2004, Arthritis and rheumatism.

[11]  R. Bowler,et al.  Extracellular Superoxide Dismutase (EC-SOD) Binds to Type I Collagen and Protects Against Oxidative Fragmentation* , 2004, Journal of Biological Chemistry.

[12]  R. Loeser,et al.  Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels. , 2003, Arthritis & Rheumatism.

[13]  R. Busse,et al.  Extracellular Superoxide Dismutase Is a Major Determinant of Nitric Oxide Bioavailability: In Vivo and Ex Vivo Evidence From ecSOD-Deficient Mice , 2003, Circulation research.

[14]  T. Oury,et al.  Extracellular superoxide dismutase in biology and medicine. , 2003, Free radical biology & medicine.

[15]  S. Murrell,et al.  High blood glutathione levels accompany excellent physical and mental health in women ages 60 to 103 years. , 2002, The Journal of laboratory and clinical medicine.

[16]  R. Bowler,et al.  Role of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis. , 2002, American journal of physiology. Lung cellular and molecular physiology.

[17]  R. Loeser,et al.  Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. , 2002, Arthritis and rheumatism.

[18]  B. Jost,et al.  Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1N mice. , 2002, Osteoarthritis and cartilage.

[19]  S. Marklund,et al.  Nitric Oxide and Blood Pressure in Mice Lacking Extracellular-Superoxide Dismutase , 2002, Free radical research.

[20]  E. Hedbom,et al.  Molecular aspects of pathogenesis in osteoarthritis: the role of inflammation , 2002, Cellular and Molecular Life Sciences CMLS.

[21]  J. Enghild,et al.  Altered expression of extracellular superoxide dismutase in mouse lung after bleomycin treatment. , 2001, Free radical biology & medicine.

[22]  I. Fridovich,et al.  Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite. , 2001, Circulation research.

[23]  M. Lamy,et al.  In vitro study of the antioxidant properties of nimesulide and 4-OH nimesulide: effects on HRP- and luminol-dependent chemiluminescence produced by human chondrocytes. , 2000, Osteoarthritis and cartilage.

[24]  S. Marklund,et al.  Multiple cytokines regulate the expression of extracellular superoxide dismutase in human vascular smooth muscle cells. , 2000, Atherosclerosis.

[25]  S. Agarwal,et al.  Cyclic Tensile Strain Acts as an Antagonist of IL-1β Actions in Chondrocytes1 , 2000, The Journal of Immunology.

[26]  P. Baeuerle,et al.  Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb , 2000 .

[27]  S. Kaneko,et al.  Interleukin-6 and interleukin-8 levels in serum and synovial fluid of patients with osteoarthritis. , 2000, Cytokines, cellular & molecular therapy.

[28]  P. Baeuerle,et al.  Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. , 2000, Free radical biology & medicine.

[29]  S. Agarwal,et al.  Cyclic tensile strain acts as an antagonist of IL-1 beta actions in chondrocytes. , 2000, Journal of immunology.

[30]  J. Pujol.  TGF-β and osteoarthritis: in vivo veritas? , 1999 .

[31]  J. Pujol.  TGF-beta and osteoarthritis: in vivo veritas? , 1999, Osteoarthritis and cartilage.

[32]  C. Helmick,et al.  Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. , 1998, Arthritis and rheumatism.

[33]  M. Schünke,et al.  Articular chondrocytes and synoviocytes in culture: influence of antioxidants on lipid peroxidation and proliferation. , 1997, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.

[34]  G. Homandberg,et al.  Fibronectin fragment mediated cartilage chondrolysis. II. Reparative effects of anti-oxidants. , 1996, Biochimica et biophysica acta.

[35]  G. Homandberg,et al.  Fibronectin fragment mediated cartilage chondrolysis. I. Suppression by anti-oxidants. , 1996, Biochimica et biophysica acta.

[36]  T. Oda,et al.  Superoxide dismutase activity in arthropathy: its role and measurement in the joints. , 1996, Hiroshima journal of medical sciences.

[37]  C. Koch,et al.  Retinoic acid modulation of glutathione and cysteine metabolism in chondrocytes. , 1996, The Biochemical journal.

[38]  S. Marklund,et al.  Immunocytochemical localization of extracellular superoxide dismutase in human lung. , 1994, Laboratory investigation; a journal of technical methods and pathology.

[39]  D. Schneider,et al.  Low blood glutathione levels in healthy aging adults. , 1992, The Journal of laboratory and clinical medicine.

[40]  S. Moncada,et al.  Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. , 1992, Annals of the rheumatic diseases.

[41]  I. Shapiro,et al.  Superoxide dismutase and catalase activities in the growth cartilage: Relationship between oxidoreductase activity and chondrocyte maturation , 1991, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[42]  J J Anderson,et al.  Factors associated with osteoarthritis of the knee in the first national Health and Nutrition Examination Survey (HANES I). Evidence for an association with overweight, race, and physical demands of work. , 1988, American journal of epidemiology.

[43]  S. Marklund,et al.  Superoxide dismutase isoenzymes of the synovial fluid in rheumatoid arthritis and in reactive arthritides. , 1986, Annals of the rheumatic diseases.

[44]  B. Halliwell,et al.  Free radicals in biology and medicine , 1985 .

[45]  J. Lunec,et al.  The determination of dehydroascorbic acid and ascorbic acid in the serum and synovial fluid of patients with rheumatoid arthritis (RA). , 1985, Free radical research communications.

[46]  T. Igari,et al.  A remarkable increase of superoxide dismutase activity in synovial fluid of patients with rheumatoid arthritis. , 1982, Clinical orthopaedics and related research.

[47]  C. Leveille,et al.  Experimentally Induced Osteoarthritis in Guinea Pigs , 1981 .

[48]  B. Ames,et al.  Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[49]  C. Leveille,et al.  Experimentally induced osteoarthritis in guinea pigs: metabolic responses in articular cartilage to developing pathology. , 1981, Arthritis and rheumatism.

[50]  V. Goldberg,et al.  A trial of intraarticular orgotein, a superoxide dismutase, in experimentally-induced osteoarthritis. , 1980, The Journal of rheumatology.

[51]  J. McCord.  Free Radicals and Inflammation: Protection of Synovial Fluid by Superoxide Dismutase , 1974, Science.