Cohort Profile: NICHD International Site Development Initiative (NISDI): a prospective, observational study of HIV-exposed and HIV-infected children at clinical sites in Latin American and Caribbean countries.

This pediatric protocol has the following scientific goals: to describe the characteristics of HIV-exposed infants and HIV-infected infants children and adolescents cared for at clinical sites in Latin America and the Caribbean to describe early and late outcomes related to HIV disease and ARV therapy and to describe early and late outcomes related to in utero exposure to ARVs and HIV and to neonatal exposure to ARVs.

[1]  D. Masys,et al.  Cohort Profile: Caribbean, Central and South America Network for HIV research (CCASAnet) collaboration within the International Epidemiologic Databases to Evaluate AIDS (IeDEA) programme. , 2007, International journal of epidemiology.

[2]  S. Stoszek,et al.  Management of Human Immunodeficiency Virus–Infected Pregnant Women at Latin American and Caribbean Sites , 2007, Obstetrics and gynecology.

[3]  S. Spector,et al.  Mitochondrial dysfunction: prevention of HIV-1 mother-to-infant transmission outweighs fear. , 2006, AIDS.

[4]  J. Bartlett,et al.  Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to reduce Perinatal HIV-1Transmission in the United States , 2003 .

[5]  J. Sleasman,et al.  HIV-1 infection , 2003 .

[6]  J. Sullivan,et al.  The changing face of pediatric HIV-1 infection. , 2001, The New England journal of medicine.

[7]  M. Hughes,et al.  Effect of combination therapy including protease inhibitors on mortality among children and adolescents infected with HIV-1. , 2001, The New England journal of medicine.

[8]  S. Gortmaker,et al.  Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams. , 1999, JAMA.

[9]  R. Gelber,et al.  Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. , 1994, The New England journal of medicine.