Disrupting proton dynamics and energy metabolism for cancer therapy
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[1] S. C. Chafe,et al. Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche , 2013, Oncogene.
[2] J. Pouysségur,et al. Hypoxia promotes tumor cell survival in acidic conditions by preserving ATP levels , 2013, Journal of cellular physiology.
[3] P. Cozzone,et al. Quantitative in vivo characterization of intracellular and extracellular pH profiles in heterogeneous tumors: a novel method enabling multiparametric pH analysis. , 2013, Cancer research.
[4] Christian M. Metallo,et al. Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells , 2013, Nature.
[5] R. Vaughan-Jones,et al. Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia , 2013, Journal of cellular physiology.
[6] Jun S. Song,et al. Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF. , 2013, Cancer cell.
[7] M. Pollak. Targeting oxidative phosphorylation: why, when, and how. , 2013, Cancer cell.
[8] C. Aalkjaer,et al. Contribution of Na+,HCO3−‐cotransport to cellular pH control in human breast cancer: A role for the breast cancer susceptibility locus NBCn1 (SLC4A7) , 2013, International journal of cancer.
[9] Robert J Gillies,et al. Acidity generated by the tumor microenvironment drives local invasion. , 2013, Cancer research.
[10] Liu Wei,et al. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. , 2013, Cancer cell.
[11] M. Honavar,et al. Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets. , 2013, Neuro-oncology.
[12] S. Marcié,et al. Knock-down of hypoxia-induced carbonic anhydrases IX and XII radiosensitizes tumor cells by increasing intracellular acidosis , 2013, Front. Oncol..
[13] Y. Isaka,et al. Chloroquine in cancer therapy: a double-edged sword of autophagy. , 2013, Cancer research.
[14] M. Malumbres,et al. HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5. , 2012, Molecular cell.
[15] Xuemei Liu,et al. Expression and functional role of vacuolar H(+)-ATPase in human hepatocellular carcinoma. , 2012, Carcinogenesis.
[16] A. Harris,et al. How cancer metabolism is tuned for proliferation and vulnerable to disruption , 2012, Nature.
[17] R. Reithmeier,et al. Membrane transport metabolons. , 2012, Biochimica et biophysica acta.
[18] M. Proescholdt,et al. Function of carbonic anhydrase IX in glioblastoma multiforme. , 2012, Neuro-oncology.
[19] A. Schwab,et al. Role of ion channels and transporters in cell migration. , 2012, Physiological reviews.
[20] Roberto Zoncu,et al. Amino acids and mTORC1: from lysosomes to disease. , 2012, Trends in molecular medicine.
[21] Bonnie F. Sloane,et al. Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. , 2012, Cancer research.
[22] Robert J Gillies,et al. Systemic buffers inhibit carcinogenesis in TRAMP mice. , 2012, The Journal of urology.
[23] P. Codogno,et al. Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress* , 2012, The Journal of Biological Chemistry.
[24] R. Gillies,et al. Evolutionary dynamics of carcinogenesis and why targeted therapy does not work , 2012, Nature Reviews Cancer.
[25] Albrecht Schwab,et al. The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2. , 2012, Cancer letters.
[26] A. Harris,et al. Importance of Intracellular pH in Determining the Uptake and Efficacy of the Weakly Basic Chemotherapeutic Drug, Doxorubicin , 2012, PloS one.
[27] J. Pouysségur,et al. Abstract 3225: Growth inhibition of glycolytic tumors by targeting basigin/lactate-H+ symporters (MCTs): Metformin sensitizes MCT inhibition , 2012 .
[28] W. Sly,et al. Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy , 2012, Clinical Cancer Research.
[29] P. Cozzone,et al. In vivo pH in metabolic‐defective Ras‐transformed fibroblast tumors: Key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH , 2012, International journal of cancer.
[30] M. Casal,et al. Role of monocarboxylate transporters in human cancers: state of the art , 2012, Journal of Bioenergetics and Biomembranes.
[31] G. Semenza,et al. Hypoxia-Inducible Factors in Physiology and Medicine , 2012, Cell.
[32] A. Halestrap. The monocarboxylate transporter family—Structure and functional characterization , 2012, IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology.
[33] K. Harper,et al. Hypoxia-Induced Invadopodia Formation Involves Activation of NHE-1 by the p90 Ribosomal S6 Kinase (p90RSK) , 2011, PloS one.
[34] J. Pastorek,et al. Carbonic Anhydrase IX Interacts with Bicarbonate Transporters in Lamellipodia and Increases Cell Migration via Its Catalytic Domain* , 2011, The Journal of Biological Chemistry.
[35] Roberto Zoncu,et al. mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase , 2011, Science.
[36] M. V. Vander Heiden,et al. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. , 2011, Annual review of cell and developmental biology.
[37] Claudiu T. Supuran,et al. Interfering with pH regulation in tumours as a therapeutic strategy , 2011, Nature Reviews Drug Discovery.
[38] J. Pouysségur,et al. CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors , 2011, Proceedings of the National Academy of Sciences.
[39] C. Supuran,et al. Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors. , 2011, Journal of medicinal chemistry.
[40] P. Sutphin,et al. Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality , 2011, Science Translational Medicine.
[41] Karen K. Y. Lam,et al. Regulation of mTORC1 Signaling by pH , 2011, PloS one.
[42] W. Sly,et al. Transport Activity of the High-affinity Monocarboxylate Transporter MCT2 Is Enhanced by Extracellular Carbonic Anhydrase IV but Not by Intracellular Carbonic Anhydrase II* , 2011, Journal of Biological Chemistry.
[43] P. Lambin,et al. Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation. , 2011, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[44] K. Landfester,et al. Omeprazole Inhibits Proliferation and Modulates Autophagy in Pancreatic Cancer Cells , 2011, PloS one.
[45] S. Leung,et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. , 2011, Cancer Research.
[46] J. Pouysségur,et al. Hypoxia and energetic tumour metabolism. , 2011, Current opinion in genetics & development.
[47] J. Pouysségur,et al. pH control mechanisms of tumor survival and growth , 2011, Journal of cellular physiology.
[48] R. McKenna,et al. Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II , 2011, Proceedings of the National Academy of Sciences.
[49] C. Stief,et al. A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX®) and interferon-alpha-2a in metastatic renal cell carcinoma patients , 2011, World Journal of Urology.
[50] A. Harris,et al. New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation , 2010, Oncogene.
[51] M. Nantz,et al. Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas , 2010, Brain Research.
[52] S. Pattingre,et al. Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells , 2010, Cell Death and Disease.
[53] J. Nylandsted,et al. NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance. , 2010, Experimental cell research.
[54] M. Tresguerres,et al. Physiological carbon dioxide, bicarbonate, and pH sensing , 2010, Pflügers Archiv - European Journal of Physiology.
[55] F. Lozupone,et al. pH‐dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity , 2010, International journal of cancer.
[56] D. Hailey,et al. Autophagy termination and lysosome reformation regulated by mTOR , 2010, Nature.
[57] R. Gatenby,et al. Proton dynamics in cancer , 2010, Journal of Translational Medicine.
[58] S. Fais. Proton pump inhibitor‐induced tumour cell death by inhibition of a detoxification mechanism , 2010, Journal of internal medicine.
[59] J. Pouysségur,et al. Hypoxia-induced autophagy: cell death or cell survival? , 2010, Current opinion in cell biology.
[60] E. Gottlieb,et al. Targeting metabolic transformation for cancer therapy , 2010, Nature Reviews Cancer.
[61] K. Hahn,et al. Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling , 2010, The Journal of cell biology.
[62] W. Boron. Evaluating the role of carbonic anhydrases in the transport of HCO3--related species. , 2010, Biochimica et biophysica acta.
[63] G. Semenza,et al. Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression , 2010, Proceedings of the National Academy of Sciences.
[64] J. Pouysségur,et al. Membrane-bound carbonic anhydrases are key pH regulators controlling tumor growth and cell migration. , 2010, Advances in enzyme regulation.
[65] Sergio Grinstein,et al. Sensors and regulators of intracellular pH , 2010, Nature Reviews Molecular Cell Biology.
[66] M. Salto‐Tellez,et al. Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo. , 2009, Cancer research.
[67] F. Oswald,et al. CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in-vivo and in-vitro models , 2009 .
[68] C. Supuran,et al. The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms. , 2009, Bioorganic & medicinal chemistry letters.
[69] L. Cantley,et al. Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.
[70] Pawel Swietach,et al. The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths* , 2009, The Journal of Biological Chemistry.
[71] M. Thun,et al. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2 , 2009, Nature Genetics.
[72] Robert J Gillies,et al. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. , 2009, Cancer research.
[73] Bonnie F. Sloane,et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. , 2009, Cancer research.
[74] N. Philp,et al. Interaction of Monocarboxylate Transporter 4 with  1 -integrin and Its Role in Cell Migration , 2022 .
[75] J. Pouysségur,et al. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. , 2009, Cancer research.
[76] Julien Verrax,et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. , 2008, The Journal of clinical investigation.
[77] P. Seglen,et al. Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? , 2008, Autophagy.
[78] J. Deitmer,et al. Nonenzymatic Proton Handling by Carbonic Anhydrase II during H+-Lactate Cotransport via Monocarboxylate Transporter 1* , 2008, Journal of Biological Chemistry.
[79] A. Harris,et al. Tumor-associated Carbonic Anhydrase 9 Spatially Coordinates Intracellular pH in Three-dimensional Multicellular Growths* , 2008, Journal of Biological Chemistry.
[80] G. Buckberg,et al. Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study. , 2008, The Annals of thoracic surgery.
[81] M. Avkiran,et al. Targeting Na+/H+ exchanger regulation for cardiac protection: a RSKy approach? , 2008, Current opinion in pharmacology.
[82] Ru Wei,et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth , 2008, Nature.
[83] Claudiu T. Supuran,et al. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators , 2008, Nature Reviews Drug Discovery.
[84] Robert J. Gillies,et al. A microenvironmental model of carcinogenesis , 2008, Nature Reviews Cancer.
[85] G. Malnic,et al. NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells , 2008, Pflügers Archiv - European Journal of Physiology.
[86] Michael Forgac,et al. Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology , 2007, Nature Reviews Molecular Cell Biology.
[87] P. Maini,et al. Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer , 2007, British Journal of Cancer.
[88] P. Matarrese,et al. Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species. , 2007, Cancer research.
[89] N. Philp,et al. Monocarboxylate transporter 4 regulates maturation and trafficking of CD147 to the plasma membrane in the metastatic breast cancer cell line MDA-MB-231. , 2007, Cancer research.
[90] R. Johnson,et al. ATP6V0C Competes with Von Hippel-Lindau Protein in Hypoxia-Inducible Factor 1α (HIF-1α) Binding and Mediates HIF-1α Expression by Bafilomycin A1 , 2007, Molecular Pharmacology.
[91] Eugene Y. Kim,et al. Evidence against a Direct Interaction between Intracellular Carbonic Anhydrase II and Pure C-terminal Domains of SLC4 Bicarbonate Transporters* , 2007, Journal of Biological Chemistry.
[92] Huaqing Zhao,et al. The H+-Linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic Target for High-Risk Neuroblastoma , 2006, Molecular Pharmacology.
[93] G. Semenza,et al. HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. , 2006, American journal of physiology. Lung cellular and molecular physiology.
[94] W. Boron,et al. Effect of Human Carbonic Anhydrase II on the Activity of the Human Electrogenic Na/HCO3 Cotransporter NBCe1-A in Xenopus Oocytes* , 2006, Journal of Biological Chemistry.
[95] E. Rofstad,et al. Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. , 2006, Cancer research.
[96] P. Leder,et al. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. , 2006, Cancer cell.
[97] J. Pouysségur,et al. Hypoxia signalling in cancer and approaches to enforce tumour regression , 2006, Nature.
[98] E. T. Gawlinski,et al. Acid-mediated tumor invasion: a multidisciplinary study. , 2006, Cancer research.
[99] A. Halestrap,et al. The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism* , 2006, Journal of Biological Chemistry.
[100] N. Denko,et al. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. , 2006, Cell metabolism.
[101] G. Semenza,et al. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. , 2006, Cell metabolism.
[102] Daniela Hirnet,et al. Transport Activity of MCT1 Expressed in Xenopus Oocytes Is Increased by Interaction with Carbonic Anhydrase* , 2005, Journal of Biological Chemistry.
[103] A. Ross,et al. Monocarboxylate transporter MCT1 is a target for immunosuppression , 2005, Nature chemical biology.
[104] Eon J. Rios,et al. Chronic hypoxia elevates intracellular pH and activates Na+/H+ exchange in pulmonary arterial smooth muscle cells. , 2005, American journal of physiology. Lung cellular and molecular physiology.
[105] R. Cardone,et al. The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis , 2005, Nature Reviews Cancer.
[106] W. Boron,et al. Regulation of intracellular pH. , 2004, Advances in physiology education.
[107] C. Supuran,et al. Hypoxia activates the capacity of tumor‐associated carbonic anhydrase IX to acidify extracellular pH , 2004, FEBS letters.
[108] R. Gillies,et al. Why do cancers have high aerobic glycolysis? , 2004, Nature Reviews Cancer.
[109] S. Gottschalk,et al. Imatinib (STI571)-Mediated Changes in Glucose Metabolism in Human Leukemia BCR-ABL-Positive Cells , 2004, Clinical Cancer Research.
[110] Adrian L Harris,et al. Role of Carbonic Anhydrase IX in Human Tumor Cell Growth, Survival, and Invasion , 2004, Cancer Research.
[111] M. Romero,et al. The SLC26 gene family of multifunctional anion exchangers , 2004, Pflügers Archiv.
[112] M. Romero,et al. The SLC4 family of HCO3− transporters , 2004, Pflügers Archiv.
[113] A. Paradiso,et al. Paclitaxel induces apoptosis via protein kinase A- and p38 mitogen-activated protein-dependent inhibition of the Na+/H+ exchanger (NHE) NHE isoform 1 in human breast cancer cells. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[114] Jin Hwan Kim,et al. Proton-sensing G-protein-coupled receptors , 2003 .
[115] Gregory S Karczmar,et al. MRI of the tumor microenvironment , 2002, Journal of magnetic resonance imaging : JMRI.
[116] U. Rodeck,et al. Regulation of intracellular pH in human melanoma: potential therapeutic implications. , 2002, Molecular cancer therapeutics.
[117] J. Casey,et al. A Transport Metabolon , 2001, The Journal of Biological Chemistry.
[118] S. McIntire,et al. A Family of Yeast Proteins Mediating Bidirectional Vacuolar Amino Acid Transport* , 2001, The Journal of Biological Chemistry.
[119] J. Pouysségur,et al. pHi, aerobic glycolysis and vascular endothelial growth factor in tumour growth. , 2001, Novartis Foundation symposium.
[120] P H Watson,et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. , 2000, Cancer research.
[121] D. Meredith,et al. Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle , 2000, The Journal of physiology.
[122] S. Caldeira,et al. Na+/H+ exchanger‐dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation‐associated phenotypes , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[123] S. Bröer,et al. The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. , 2000, The Biochemical journal.
[124] A. Barclay,et al. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression , 2000, The EMBO journal.
[125] O. Garden,et al. Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger. , 2000, Blood.
[126] R. Gillies,et al. pH and drug resistance. I. Functional expression of plasmalemmal V-type H+-ATPase in drug-resistant human breast carcinoma cell lines. , 1999, Biochemical pharmacology.
[127] Y. Moriyama,et al. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. , 1998, Cell structure and function.
[128] Rakesh K. Jain,et al. Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation , 1997, Nature Medicine.
[129] J. Pouysségur,et al. Molecular physiology of vertebrate Na+/H+ exchangers. , 1997, Physiological reviews.
[130] E. T. Gawlinski,et al. A reaction-diffusion model of cancer invasion. , 1996, Cancer research.
[131] L. Gerweck,et al. Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. , 1996, Cancer research.
[132] G. Semenza,et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[133] H. Guo,et al. The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. , 1995, Cancer research.
[134] A. Halestrap,et al. N-terminal protein sequence analysis of the rabbit erythrocyte lactate transporter suggests identity with the cloned monocarboxylate transport protein MCT1. , 1994, The Biochemical journal.
[135] R. Kettmann,et al. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment. , 1994, Oncogene.
[136] I. Tannock,et al. Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy. , 1994, British Journal of Cancer.
[137] Richard G. W. Anderson,et al. Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: Implications for the Cori cycle , 1994, Cell.
[138] Y. Moriyama,et al. Evidence for a common binding site for omeprazole and N-ethylmaleimide in subunit A of chromaffin granule vacuolar-type H(+)-ATPase. , 1993, Biochemical and biophysical research communications.
[139] R. Gillies,et al. Vacuolar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells. , 1993, The American journal of physiology.
[140] A. Halestrap,et al. Transport of lactate and other monocarboxylates across mammalian plasma membranes. , 1993, The American journal of physiology.
[141] K. Väänänen,et al. Omeprazole and bafilomycin, two proton pump inhibitors: differentiation of their effects on gastric, kidney and bone H(+)-translocating ATPases. , 1991, Biochimica et biophysica acta.
[142] P. Okunieff,et al. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. , 1989, Cancer research.
[143] I. Tannock,et al. Reduction of intracellular pH as a possible mechanism for killing cells in acidic regions of solid tumors: effects of carbonylcyanide-3-chlorophenylhydrazone. , 1989, Cancer research.
[144] J. Davoust,et al. Low cytoplasmic pH inhibits endocytosis and transport from the trans- Golgi network to the cell surface , 1989, The Journal of cell biology.
[145] C. Sardet,et al. Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+ H+ , 1989, Cell.
[146] S Grinstein,et al. Requirement of the Na + / H + Exchanger for Tumor Growth 1 , 2006 .
[147] I. Tannock,et al. Cytotoxicity of compounds that interfere with the regulation of intracellular pH: a potential new class of anticancer drugs. , 1987, Cancer research.
[148] J. Pouysségur,et al. Intracellular pH controls growth factor-induced ribosomal protein S6 phosphorylation and protein synthesis in the G0----G1 transition of fibroblasts. , 1986, Experimental cell research.
[149] I. Tannock,et al. Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors. , 1986, Cancer research.
[150] J. Pouysségur,et al. Cytoplasmic pH, a key determinant of growth factor‐induced DNA synthesis in quiescent fibroblasts , 1985, FEBS letters.
[151] H. Lodish,et al. Primary structure and transmembrane orientation of the murine anion exchange protein , 1985, Nature.
[152] J. Haveman,et al. The relevance of tumour pH to the treatment of malignant disease. , 1984, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[153] C. Sardet,et al. A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH. , 1984, Proceedings of the National Academy of Sciences of the United States of America.
[154] J. Pouysségur,et al. Growth factor action and intracellular pH regulation in fibroblasts. Evidence for a major role of the Na+/H+ antiport. , 1984, The Journal of biological chemistry.
[155] J. Pouysségur,et al. Biochemical characterization of the amiloride-sensitive Na+/H+ antiport in Chinese hamster lung fibroblasts. , 1983, The Journal of biological chemistry.
[156] O. Andersen,et al. Chloride--bicarbonate exchange in red blood cells: physiology of transport and chemical modification of binding sites. , 1982, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
[157] P. Aronson,et al. Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles , 1982, Nature.
[158] J. Pouysségur,et al. Growth factor activation of an amiloride-sensitive Na+/H+ exchange system in quiescent fibroblasts: coupling to ribosomal protein S6 phosphorylation. , 1982, Proceedings of the National Academy of Sciences of the United States of America.
[159] W. Boron,et al. Intracellular pH. , 1981, Physiological reviews.
[160] I. Cameron,et al. Cellular potentials of normal and cancerous fibroblasts and hepatocytes. , 1980, Cancer research.
[161] D. Epel,et al. Intracellular pH and activation of sea urchin eggs after fertilisation , 1976, Nature.
[162] D. Burk,et al. On respiratory impairment in cancer cells. , 1956, Science.
[163] H. Kahler,et al. THE ESTIMATION OF THE HYDROGEN-ION CONCENTRATION OF THE TISSUES IN LIVING ANIMALS. , 1932, Science.
[164] Otto Warburn,et al. THE METABOLISM OF TUMORS , 1931 .
[165] O. Warburg,et al. THE METABOLISM OF TUMORS IN THE BODY , 1927, The Journal of general physiology.