Reducation of digitalis toxicity by computer-assisted glycoside dosage regimens.

Abstract Computer-assisted dosage regimens of digitalis leaf, digitoxin, digoxin, and deslanoside (Cedilanid-D®) have reduced the frequency of adverse reactions to such glycosides from 35% to 12% (...

[1]  R. Goldman.  Creatinine Excretion in Renal Failure.∗ , 1954, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[2]  J. Doherty,et al.  Tritiated digoxin studies in human subjects. , 1961, Archives of internal medicine.

[3]  F. Wasserman,et al.  Observations on digitalis intoxication. , 1961, Archives of internal medicine.

[4]  J. Doherty,et al.  Studies with tritiated digoxin in human subjects after intravenous administration. , 1962, American heart journal.

[5]  R. E. Peterson,et al.  Double isotope dilution derivative assay of digitoxin in plasma, urine, and stool of patients maintained on the drug. , 1966, The Journal of clinical investigation.

[6]  A. Weissler,et al.  Assay of digitalis glycosides in man , 1966 .

[7]  F. Marcus,et al.  Administration of Tritiated Digoxin with and without a Loading Dose: A Metabolic Study , 1966, Circulation.

[8]  R. Jelliffe.  A mathematical analysis of digitalis kinetics in patients with normal and reduced renal function , 1967 .

[9]  Autopsy verification of suicide by digitalis. Report of a case, with successful chemical identification of digitalis glycosides in gastric contents. , 1967, American journal of clinical pathology.

[10]  J. Doherty,et al.  The distribution and concentration of tritiated digoxin in human tissues. , 1967, Annals of internal medicine.

[11]  R. Jelliffe.  An improved method of digoxin therapy. , 1968, Annals of internal medicine.

[12]  C. Parker,et al.  The measurement of digitoxin in human serum by radioimmunoassay. , 1968, The Journal of clinical investigation.

[13]  D. Grahame-Smith,et al.  Measurement of Digoxin in Plasma and its use in Diagnosis of Digoxin Intoxication , 1969, British medical journal.

[14]  P. Binnion,et al.  Plasma and myocardial digoxin concentrations in patients on oral therapy. , 1969, British heart journal.

[15]  R. Jelliffe.  Administration of digoxin. , 1969, Diseases of the chest.

[16]  R. Jelliffe,et al.  A fluorometric determination of myocardial digoxin at autopsy, with identification of digitalis leaf, digitoxin, and gitoxin. , 1969, American journal of clinical pathology.

[17]  E. Haber,et al.  Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay. , 1969, The New England journal of medicine.

[18]  Roger W. Jelliffe,et al.  A mathematical study of the metabolic conversion of digitoxin to digoxin in man , 1970 .

[19]  R. Kalaba,et al.  An improved method of digitoxin therapy. , 1970, Annals of internal medicine.

[20]  Jelliffe Rw.  An improved method for replacing one digitalis glycoside with another. , 1970 .

[21]  C. Hayter,et al.  Measurement of Plasma Digoxin Concentration by Radioimmunoassay , 1970, British medical journal.

[22]  E. Haber,et al.  Digoxin intoxication: the relationship of clinical presentation to serum digoxin concentration. , 1970, The Journal of clinical investigation.

[23]  J. Doherty,et al.  Tritiated Digoxin: XIV. Enterohepatic Circulation, Absorption, and Excretion Studies in Human Volunteers , 1970, Circulation.

[24]  R. Kalaba,et al.  A computer program for digitalis dosage regimens , 1970 .

[25]  H. T. Howat,et al.  Rapid evaluation of creatinine clearance. , 1971, Lancet.

[26]  M. Mellow,et al.  Variation in biologic availability of digoxin from four preparations. , 1971, The New England journal of medicine.

[27]  R. Jelliffe.  Factors to consider in planning digoxin therapy. , 1971, Journal of chronic diseases.

[28]  R. Jelliffe,et al.  Estimation of creatinine clearance from changing serum-creatinine levels. , 1971, Lancet.

[29]  W. Abelmann,et al.  Digitalis intoxication. A prospective clinical study with serum level correlations. , 1971, The New England journal of medicine.

[30]  A. Fogelman,et al.  Fallibility of plasma-digoxin in differentiating toxic from non-toxic patients. , 1971, Lancet.

[31]  T. Smith.  Contribution of Quantitative Assay Technics to the Understanding of the Clinical Pharmacology of Digitalis , 1972, Circulation.

[32]  R. Jelliffe,et al.  A computer program for estimation of creatinine clearance from unstable serum creatinine levels, age, sex, and weight , 1972 .

[33]  R. Jelliffe,et al.  Serum Cardiac Glycoside Assay Based upon Displacement of 3H‐Ouabain from Na‐K ATPase , 1972, Circulation.

[34]  M. Kristensen,et al.  Rapid evaluation of creatinine clearance. , 1971, Acta medica Scandinavica.