Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

Ruan et al. show that brain-derived extracellular vesicles from human donors with Alzheimer’s disease propagate tau more efficiently when injected into the mouse hippocampus than oligomeric or fibrillary tau from the same donors. The extracellular vesicles preferentially spread tau pathology to interneurons.

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