Current complementary and alternative therapy forgastroesophageal reflux disease

Abstract Gastroesophageal reflux disease (GERD) is a widely prevalent gastrointestinal disorder, affecting ∼13.3% of the global population. There are shortages and limitations of current GERD treatment modalities, and complementary and alternative therapy (CAT) is a promising option to fill in the gap. Dietary and lifestyle modifications might play an important and complementary role in alleviating GERD symptoms. Traditional Chinese medicine and brain–gut behavior therapy, particularly transcutaneous electrical acustimulation and diaphragmatic breathing therapy were shown to be useful adjuncts or alternatives in treating GERD. CAT may help to relieve GERD symptoms, minimize medication dosage, and slow the demand for surgery. The aim of this review was to summarize the existing evidence of some common CATs in treating symptomatic GERD, including dietary modification, lifestyle change, traditional Chinese medicine, and brain–gut behavior therapy.

[1]  R. Wilson,et al.  Current management of gastro-oesophageal reflux disease—treatment costs, safety profile, and effectiveness: a narrative review , 2022, Gastroenterology report.

[2]  Yu Yao,et al.  Herbal Medicine Hewei Jiangni Decoction Is Noninferior to Oral Omeprazole for the Treatment of Nonerosive Gastroesophageal Reflux Disease: A Randomized, Double-Blind, and Double-Dummy Controlled Trail , 2022, Evidence-based complementary and alternative medicine : eCAM.

[3]  Hao Chen,et al.  Mechanisms of Chinese Medicine in Gastroesophageal Reflux Disease Treatment: Data Mining and Systematic Pharmacology Study , 2022, Chinese Journal of Integrative Medicine.

[4]  M. Vaezi,et al.  The Effects of Modifying Amount and Type of Dietary Carbohydrate on Esophageal Acid Exposure Time and Esophageal Reflux Symptoms: A Randomized Controlled Trial , 2022, The American journal of gastroenterology.

[5]  A. Bredenoord,et al.  Sleep positional therapy for nocturnal gastroesophageal reflux: a double-blind, randomized, sham-controlled trial. , 2022, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[6]  S. Larsson,et al.  Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study , 2022, European Journal of Epidemiology.

[7]  S. Gonlachanvit,et al.  The Effect of Rice vs. Wheat Ingestion on Postprandial Gastroesophageal Reflux (GER) Symptoms in Patients with Overlapping GERD-Irritable Bowel Syndrome (IBS) , 2021, Foods.

[8]  S. Spechler,et al.  ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. , 2021, The American journal of gastroenterology.

[9]  Xiaopei Gao,et al.  Gastroesophageal reflux disease: recent innovations in endoscopic assessment and treatment , 2021, Gastroenterology report.

[10]  X. Hou,et al.  Prevalence and beverage‐related risk factors of gastroesophageal reflux disease: An original study in Chinese college freshmen, a systemic review and meta‐analysis , 2021, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[11]  D. Drossman,et al.  A Rome Working Team Report on Brain-Gut Behavior Therapies for Disorders of Gut-Brain Interaction. , 2021, Gastroenterology.

[12]  S. Spechler,et al.  Obesity and Its Effects on the Esophageal Mucosal Barrier. , 2021, American journal of physiology. Gastrointestinal and liver physiology.

[13]  Shengsheng Zhang,et al.  Modified Xiaochaihu Decoction for gastroesophageal reflux disease: A randomized double-simulation controlled trial , 2021, World journal of gastroenterology.

[14]  P. Kahrilas,et al.  Umbrella review of 42 systematic reviews with meta‐analyses: the safety of proton pump inhibitors , 2021, Alimentary pharmacology & therapeutics.

[15]  Yinglian Xiao,et al.  Chinese expert consensus on gastroesophageal reflux disease in 2020 , 2021, Journal of digestive diseases.

[16]  S. Roman,et al.  Low FODMAPs diet or usual dietary advice for the treatment of refractory gastroesophageal reflux disease: An open‐labeled randomized trial , 2021, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[17]  Xudong Tang,et al.  JianpiQinghua granule reduced PPI dosage in patients with nonerosive reflux disease: A multicenter, randomized, double-blind, double-dummy, noninferiority study. , 2021, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[18]  Xin-lin Chen,et al.  Dietary and Lifestyle Factors Related to Gastroesophageal Reflux Disease: A Systematic Review , 2021, Therapeutics and clinical risk management.

[19]  Jiande D. Z. Chen,et al.  Integrative Effects and Vagal Mechanisms of Transcutaneous Electrical Acustimulation on Gastroesophageal Motility in Patients With Gastroesophageal Reflux Disease , 2021, The American journal of gastroenterology.

[20]  L. Nguyen,et al.  Association of Diet and Lifestyle With the Risk of Gastroesophageal Reflux Disease Symptoms in US Women. , 2021, JAMA internal medicine.

[21]  M. Crowell,et al.  Effects of Diaphragmatic Breathing on the Pathophysiology and Treatment of Upright Gastroesophageal Reflux: A Randomized Controlled Trial. , 2020, The American journal of gastroenterology.

[22]  C. Tang,et al.  Different Traditional Herbal Medicines for the Treatment of Gastroesophageal Reflux Disease in Adults , 2020, Frontiers in Pharmacology.

[23]  E. Savarino,et al.  Elimination of Dietary Triggers Is Successful in Treating Symptoms of Gastroesophageal Reflux Disease , 2020, Digestive Diseases and Sciences.

[24]  Qipeng Wei,et al.  Efficacy of Chinese Herbal Formula Sini Zuojin Decoction in Treating Gastroesophageal Reflux Disease: Clinical Evidence and Potential Mechanisms , 2020, Frontiers in Pharmacology.

[25]  Bei-fang Ning,et al.  Ameliorating Effects and Autonomic Mechanisms of Transcutaneous Electrical Acustimulation in Patients With Gastroesophageal Reflux Disease , 2019, Neuromodulation : journal of the International Neuromodulation Society.

[26]  Christopher V. Almario,et al.  Prevalence of Gastroesophageal Reflux Disease and Proton Pump Inhibitor-Refractory Symptoms. , 2019, Gastroenterology.

[27]  A. Chan,et al.  Association Between Beverage Intake and Incidence of Gastroesophageal Reflux Symptoms: Beverages and GER symptoms. , 2019, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[28]  Jiande D. Z. Chen,et al.  Ameliorating Effects of Transcutaneous Electrical Acustimulation Combined With Deep Breathing Training on Refractory Gastroesophageal Reflux Disease Mediated via the Autonomic Pathway , 2019, Neuromodulation : journal of the International Neuromodulation Society.

[29]  Zhaohong Shi,et al.  Elevation of Lower Esophageal Sphincter Pressure With Acute Transcutaneous Electrical Acustimulation Synchronized With Inspiration , 2019, Neuromodulation : journal of the International Neuromodulation Society.

[30]  C. Hsieh,et al.  Effect of wu chu yu tang on gastroesophageal reflux disease: Randomized, double-blind, placebo-controlled trial. , 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[31]  Suhas Chandran,et al.  The effectiveness of mindfulness meditation in relief of symptoms of depression and quality of life in patients with gastroesophageal reflux disease , 2019, Indian Journal of Gastroenterology.

[32]  V. Isakov,et al.  Fiber-enriched diet helps to control symptoms and improves esophageal motility in patients with non-erosive gastroesophageal reflux disease , 2018, World journal of gastroenterology.

[33]  P. Hajek,et al.  Treatment of supragastric belching with cognitive behavioral therapy improves quality of life and reduces acid gastroesophageal reflux , 2018, The American Journal of Gastroenterology.

[34]  P. Thota,et al.  Endoscopic Treatments of GERD , 2018, Current Treatment Options in Gastroenterology.

[35]  Qingguo Wang,et al.  Acupuncture for the Treatment of Gastro-Oesophageal Reflux Disease: A Systematic Review and Meta-Analysis , 2017, Acupuncture in medicine : journal of the British Medical Acupuncture Society.

[36]  H. El‐Serag,et al.  Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal Reflux , 2017, JAMA.

[37]  Wei Wei,et al.  Electrical therapies for gastrointestinal motility disorders , 2017, Expert review of gastroenterology & hepatology.

[38]  F. Bazzoli,et al.  Global prevalence of, and risk factors for, gastro-oesophageal reflux symptoms: a meta-analysis , 2017, Gut.

[39]  Yun-Kai Dai,et al.  Efficacy and Safety of Modified Banxia Xiexin Decoction (Pinellia Decoction for Draining the Heart) for Gastroesophageal Reflux Disease in Adults: A Systematic Review and Meta-Analysis , 2017, Evidence-based complementary and alternative medicine : eCAM.

[40]  L. Keefer,et al.  Psychological Interventions for Irritable Bowel Syndrome and Inflammatory Bowel Diseases , 2017, Clinical and translational gastroenterology.

[41]  G. Burazeri,et al.  Adherence to a predominantly Mediterranean diet decreases the risk of gastroesophageal reflux disease: a cross-sectional study in a South Eastern European population. , 2016, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

[42]  X. Liu,et al.  Short-term and long-term effect of diaphragm biofeedback training in gastroesophageal reflux disease: an open-label, pilot, randomized trial. , 2016, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

[43]  Bin Lu,et al.  Effects of Transcutaneous Electrical Acustimulation on Refractory Gastroesophageal Reflux Disease , 2016, Evidence-based complementary and alternative medicine : eCAM.

[44]  M. Vaezi,et al.  Dietary carbohydrate intake, insulin resistance and gastro‐oesophageal reflux disease: a pilot study in European‐ and African‐American obese women , 2016, Alimentary pharmacology & therapeutics.

[45]  K. Tominaga,et al.  Long-Term Benefits of Smoking Cessation on Gastroesophageal Reflux Disease and Health-Related Quality of Life , 2016, PloS one.

[46]  H. El‐Serag,et al.  Lifestyle Intervention in Gastroesophageal Reflux Disease. , 2016, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[47]  C. Rife,et al.  A Novel Sleep Positioning Device Reduces Gastroesophageal Reflux: A Randomized Controlled Trial , 2015, Journal of clinical gastroenterology.

[48]  Yan-Mei Huang,et al.  Consistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders. , 2015, The American journal of Chinese medicine.

[49]  D. Sifrim,et al.  Supragastric Belching: Prevalence and Association With Gastroesophageal Reflux Disease and Esophageal Hypomotility , 2015, Journal of neurogastroenterology and motility.

[50]  K. Hveem,et al.  Risk Factors on the Development of New-Onset Gastroesophageal Reflux Symptoms. A Population-Based Prospective Cohort Study: The HUNT Study , 2015, The American Journal of Gastroenterology.

[51]  C. Rayner,et al.  Effect of liquid meals with different volumes on gastroesophageal reflux disease , 2014, Journal of gastroenterology and hepatology.

[52]  K. Hveem,et al.  Tobacco Smoking Cessation and Improved Gastroesophageal Reflux: A Prospective Population-Based Cohort Study: The HUNT Study , 2014, The American Journal of Gastroenterology.

[53]  R. Vardar,et al.  The influence of the speed of food intake on multichannel impedance in patients with gastro-oesophageal reflux disease , 2013, United European gastroenterology journal.

[54]  K. Hveem,et al.  Weight Loss and Reduction in Gastroesophageal Reflux. A Prospective Population-Based Cohort Study: The HUNT Study , 2013, The American Journal of Gastroenterology.

[55]  E. Roshi,et al.  Lifestyle Characteristics and Gastroesophageal Reflux Disease: A Population-Based Study in Albania , 2013, Gastroenterology research and practice.

[56]  Bryan K. Smith,et al.  Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: A prospective intervention trial , 2012, Obesity.

[57]  G. M. Gulzar,et al.  Effect of bed head elevation during sleep in symptomatic patients of nocturnal gastroesophageal reflux , 2012, Journal of gastroenterology and hepatology.

[58]  N. Yamamichi,et al.  Lifestyle factors affecting gastroesophageal reflux disease symptoms: a cross-sectional study of healthy 19864 adults using FSSG scores , 2012, BMC Medicine.

[59]  T. Hinterleitner,et al.  Positive Effect of Abdominal Breathing Exercise on Gastroesophageal Reflux Disease: A Randomized, Controlled Study , 2012, The American Journal of Gastroenterology.

[60]  Xudong Tang,et al.  A randomized, controlled, double-blinded and double-dummy trial of the effect of Tongjiang Granule (通降颗粒) on the nonerosive reflux disease of and Gan (肝)-Wei (胃) incoordination syndrome , 2011, Chinese journal of integrative medicine.

[61]  Jieyun Yin,et al.  Gastrointestinal motility disorders and acupuncture , 2010, Autonomic Neuroscience.

[62]  Rosanna Abbate,et al.  Adherence to Mediterranean diet and health status: meta-analysis , 2008, BMJ : British Medical Journal.

[63]  P. Wahlqvist,et al.  Relationship between symptom load of gastro‐oesophageal reflux disease and health‐related quality of life, work productivity, resource utilization and concomitant diseases: survey of a US cohort , 2008, Alimentary pharmacology & therapeutics.

[64]  M. Wallander,et al.  Severe gastro‐oesophageal reflux symptoms in relation to anxiety, depression and coping in a population‐based study , 2007, Alimentary pharmacology & therapeutics.

[65]  M. Fox,et al.  The effects of dietary fat and calorie density on esophageal acid exposure and reflux symptoms. , 2007, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[66]  C. Camargo,et al.  Body-mass index and symptoms of gastroesophageal reflux in women. , 2006, The New England journal of medicine.

[67]  Ming-Shiang Wu,et al.  Comparative analysis between psychological and endoscopic profiles in patients with gastroesophageal reflux disease: A prospective study based on screening endoscopy , 2006, Journal of gastroenterology and hepatology.

[68]  A. Bredenoord,et al.  Effect of dietary sodium chloride on gastro-oesophageal reflux: A randomized controlled trial , 2006, Scandinavian journal of gastroenterology.

[69]  S. Willich,et al.  Lifestyle factors and symptoms of gastro‐oesophageal reflux – a population‐based study , 2006, Alimentary pharmacology & therapeutics.

[70]  K. Tominaga,et al.  Association Between Dinner-to-Bed Time and Gastro-Esophageal Reflux Disease , 2005, The American Journal of Gastroenterology.

[71]  J. Silny,et al.  Gastric Fullness, Physical Activity, and Proximal Extent of Gastroesophageal Reflux , 2005, The American Journal of Gastroenterology.

[72]  H. El‐Serag,et al.  Dietary intake and the risk of gastro-oesophageal reflux disease: a cross sectional study in volunteers , 2004, Gut.

[73]  K. Hveem,et al.  Lifestyle related risk factors in the aetiology of gastro-oesophageal reflux , 2004, Gut.

[74]  D. Castell,et al.  The Influence of Rapid Food Intake on Postprandial Reflux: Studies in Healthy Volunteers , 2004, The American Journal of Gastroenterology.

[75]  J. Holst,et al.  Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease. , 2003, Gastroenterology.

[76]  M. Samsom,et al.  Effect of different recumbent positions on postprandial gastroesophageal reflux in normal subjects , 2000, American Journal of Gastroenterology.

[77]  C. Pehl,et al.  Effect of low and high fat meals on lower esophageal sphincter motility and gastroesophageal reflux in healthy subjects , 1999, American Journal of Gastroenterology.

[78]  R. Penagini,et al.  Effect of increasing the fat content but not the energy load of a meal on gastro-oesophageal reflux and lower oesophageal sphincter motor function , 1998, Gut.

[79]  M. Abbasi,et al.  Effects of Life style factors on the symptoms of gastro esophageal reflux disease: A cross sectional study in a Pakistani population , 2020, Pakistan journal of medical sciences.

[80]  R. Fitzgerald,et al.  Esophageal Diseases. , 2018, Gastroenterology.

[81]  S. Bor,et al.  The effect of the speed of eating on acid reflux and symptoms of patients with gastroesophageal reflux disease. , 2013, The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.

[82]  N. Pedersen,et al.  Lifestyle factors and risk for symptomatic gastroesophageal reflux in monozygotic twins. , 2007, Gastroenterology.

[83]  M. Mędraś,et al.  Gastroesophageal Reflux Disease and Physical Activity , 2006, Sports medicine.

[84]  D. Chang,et al.  Original Article Relationship Between Gastroesophageal Reflux Symptoms and Dietary Factors in Korea , 2022 .