Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: possible confounding effects on in vivo and in vitro studies.

[1]  P. Seale Orexin turns up the heat on obesity. , 2011, Cell metabolism.

[2]  S. Bhatnagar,et al.  Orexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress. , 2011, Endocrinology.

[3]  M. Lutter,et al.  Hcrtr1 and 2 signaling differentially regulates depression-like behaviors , 2011, Behavioural Brain Research.

[4]  L. Kubin,et al.  Antagonism of orexin 1 receptors eliminates motor hyperactivity and improves homing response acquisition in juvenile rats exposed to alcohol during early postnatal period , 2011, Behavioural Brain Research.

[5]  M. Zaretskaia,et al.  The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area , 2011, Neuroscience Letters.

[6]  A. Lawrence,et al.  The orexin1 receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats , 2011, Brain Research.

[7]  S. Runyon,et al.  Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists. , 2011, Bioorganic & medicinal chemistry letters.

[8]  C. Mediavilla,et al.  SB-334867-A, a selective orexin-1 receptor antagonist, enhances taste aversion learning and blocks taste preference learning in rats , 2011, Pharmacology Biochemistry and Behavior.

[9]  S. Ikemoto,et al.  Intraventricular administration of neuropeptide S has reward-like effects. , 2011, European journal of pharmacology.

[10]  C. Heidbreder,et al.  Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward , 2011, Behavioural pharmacology.

[11]  S. Onizuka,et al.  Effects of orexin-A on propofol anesthesia in rats , 2011, Journal of Anesthesia.

[12]  R. Lydic,et al.  Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness. , 2010, Sleep.

[13]  JaneR . Taylor,et al.  Orexin Signaling Via the Orexin 1 Receptor Mediates Operant Responding for Food Reinforcement , 2010, Biological Psychiatry.

[14]  JaneR . Taylor,et al.  Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization , 2010, Brain Research.

[15]  R. Maldonado,et al.  Hypocretins Regulate the Anxiogenic-Like Effects of Nicotine and Induce Reinstatement of Nicotine-Seeking Behavior , 2010, The Journal of Neuroscience.

[16]  E. Nattie,et al.  The orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle , 2010, Respiratory Physiology & Neurobiology.

[17]  Z. Şahin,et al.  Orexins activates protein kinase C-mediated Ca(2+) signaling in isolated rat primary sensory neurons. , 2010, Physiological research.

[18]  J-A Yan,et al.  Orexin affects dorsal root ganglion neurons: a mechanism for regulating the spinal nociceptive processing. , 2008, Physiological research.

[19]  A. Lawrence,et al.  The orexin system regulates alcohol‐seeking in rats , 2006, British journal of pharmacology.

[20]  F. Tingley,et al.  3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation , 2005 .

[21]  M. Don,et al.  Nitrogen-containing compounds from Salvia miltiorrhiza. , 2005, Journal of natural products.

[22]  V. Boev,et al.  Synthesis and antimicrobial activity of 5(6)-isothiocyanatobenzazoles , 1990, Pharmaceutical Chemistry Journal.

[23]  P. Jeffrey,et al.  1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor. , 2001, Bioorganic & medicinal chemistry letters.

[24]  J. Arch,et al.  A selective orexin-1 receptor antagonist reduces food consumption in male and female rats , 2000, Regulatory Peptides.

[25]  X. Qian,et al.  Novel and highly efficient DNA photocleavers: hydroperoxides of heterocyclic-fused naphthalimides , 2000 .

[26]  G. Riley,et al.  Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement , 2000, Psychopharmacology.

[27]  D. Clarke,et al.  Reexamination of the thermolytic rearrangement of 4-halophenyl azides to 2-aminophenols and other products , 1993 .

[28]  Hidetoshi Kobayashi,et al.  2-t-Butyl-5-chloro-6-nitrobenzoxazole: a practical synthetic intermediate for 4-aryloxy-5-nitro-2-aminophenols , 1988 .

[29]  J. B. Wright The synthesis of benzoxazole-5-acetic acid derivatives , 1972 .