Advances in systems biology: computational algorithms and applications

The 2012 International Conference on Intelligent Biology and Medicine (ICIBM 2012) was held on April 22-24, 2012 in Nashville, Tennessee, USA. The conference featured six technical sessions, one tutorial session, one workshop, and 3 keynote presentations that covered state-of-the-art research activities in genomics, systems biology, and intelligent computing. In addition to a major emphasis on the next generation sequencing (NGS)-driven informatics, ICIBM 2012 aligned significant interests in systems biology and its applications in medicine. We highlight in this editorial the selected papers from the meeting that address the developments of novel algorithms and applications in systems biology.

[1]  Hua Xu,et al.  Genetic studies of complex human diseases: Characterizing SNP-disease associations using Bayesian networks , 2012, BMC Systems Biology.

[2]  T. Ideker,et al.  A decade of systems biology. , 2010, Annual review of cell and developmental biology.

[3]  Hua Xu,et al.  Genomics in 2012: challenges and opportunities in the next generation sequencing era , 2012, BMC Genomics.

[4]  Jake Yue Chen,et al.  Genome-wide meta-analysis of genetic susceptible genes for Type 2 Diabetes , 2012, BMC Systems Biology.

[5]  A. Barabasi,et al.  Network medicine : a network-based approach to human disease , 2010 .

[6]  Cheng Zhu,et al.  A vertex similarity-based framework to discover and rank orphan disease-related genes , 2012, BMC Systems Biology.

[7]  Meng Zhao,et al.  A semantic proteomics dashboard (SemPoD) for data management in translational research , 2012, BMC Systems Biology.

[8]  Yufang Jin,et al.  Mathematical modeling of left ventricular dimensional changes in mice during aging , 2012, BMC Systems Biology.

[9]  Yang Liu,et al.  Integrative pathway analysis of genome-wide association studies and gene expression data in prostate cancer , 2012, BMC Systems Biology.

[10]  Hang Zhang,et al.  A strategy to study pathway cross-talks of cells under repetitive exposure to stimuli , 2012, BMC Systems Biology.

[11]  Xuan Li,et al.  Optimizing hybrid assembly of next-generation sequence data from Enterococcus faecium: a microbe with highly divergent genome , 2012, BMC Systems Biology.

[12]  Hao Ye,et al.  Potential metabolic mechanism of girls' central precocious puberty: a network analysis on urine metabonomics data , 2012, BMC Systems Biology.

[13]  Yang Xiang,et al.  A dynamic time order network for time-series gene expression data analysis , 2012, BMC Systems Biology.

[14]  Xuan Li,et al.  A cross-species analysis method to analyze animal models' similarity to human's disease state , 2012, BMC Systems Biology.

[15]  Xinghua Lu,et al.  Revealing functionally coherent subsets using a spectral clustering and an information integration approach , 2012, BMC Systems Biology.

[16]  Ru Shen,et al.  Mining functional subgraphs from cancer protein-protein interaction networks , 2012, BMC Systems Biology.

[17]  Hong Sun,et al.  An improved dimensionality reduction method for meta-transcriptome indexing based diseases classification , 2012, BMC Systems Biology.

[18]  Yufeng Wang,et al.  Module-based subnetwork alignments reveal novel transcriptional regulators in malaria parasite Plasmodium falciparum , 2012, BMC Systems Biology.

[19]  Huiru Zheng,et al.  Detection of protein complexes from affinity purification/mass spectrometry data , 2012, BMC Systems Biology.

[20]  W. Jim Zheng,et al.  Signaling network prediction by the Ontology Fingerprint enhanced Bayesian network , 2012, BMC Systems Biology.

[21]  Yu Liu,et al.  Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data , 2012, BMC Systems Biology.

[22]  Xi Chen,et al.  Statistical aspects of omics data analysis using the random compound covariate , 2012, BMC Systems Biology.

[23]  Meeta Pradhan,et al.  Cliques for the identification of gene signatures for colorectal cancer across population , 2012, BMC Systems Biology.