Variational analysis of the mouse and rat eye optical parameters.

Rodent models are increasingly used to study refractive eye development and development of refractive errors; however, there is still some uncertainty regarding the accuracy of the optical models of the rat and mouse eye primarily due to high variability in reported ocular parameters. In this work, we have systematically evaluated the contribution of various ocular parameters, such as radii of curvature of ocular surfaces, thicknesses of ocular components, and refractive indices of ocular refractive media, using variational analysis and a computational model of the rodent eye. Variational analysis revealed that not all variation in ocular parameters has critical impact on the refractive status of the eye. Variation in the depth of the vitreous chamber, thickness of the lens, radius of the anterior surface of the cornea, radius of the anterior surface of the lens, as well as refractive indices for the lens and vitreous, appears to have the largest impact on the refractive error. The radii of the posterior surfaces of the cornea and lens have much smaller contributions to the refractive state. These data provide the framework for further refinement of the optical models of the rat and mouse eye and suggest that extra efforts should be directed towards increasing the linear resolution of the rodent eye biometry and obtaining more accurate data for the refractive indices of the lens and vitreous.

[1]  J. Tuo,et al.  Effects of Flickering Light on Refraction and Changes in Eye Axial Length of C57BL/6 Mice , 2011, Ophthalmic Research.

[2]  Frank Schaeffel,et al.  A paraxial schematic eye model for the growing C57BL/6 mouse , 2004, Vision Research.

[3]  F. Schaeffel,et al.  Contrast sensitivity of wildtype mice wearing diffusers or spectacle lenses, and the effect of atropine , 2006, Vision Research.

[4]  R. Williams,et al.  Mouse models for the analysis of myopia: an analysis of variation in eye size of adult mice. , 1999, Optometry and vision science : official publication of the American Academy of Optometry.

[5]  Robert W. Williams,et al.  Measurement of Refractive State and Deprivation Myopia in Two Strains of Mice , 2004, Optometry and vision science : official publication of the American Academy of Optometry.

[6]  Phillip Bedggood,et al.  Limitations to adaptive optics image quality in rodent eyes , 2012, Biomedical optics express.

[7]  Susana Marcos,et al.  Optical aberrations in the mouse eye , 2006, Vision Research.

[8]  Josep Arasa,et al.  Paraxial Ray Tracing , 2004 .

[9]  J. Boatright,et al.  Exaggerated eye growth in IRBP-deficient mice in early development. , 2011, Investigative ophthalmology & visual science.

[10]  R. Schechter.  Snell's Law: optimum pathway analysis. , 1977, Survey of ophthalmology.

[11]  Jianhua Wang,et al.  Genetic deletion of the adenosine A2A receptor confers postnatal development of relative myopia in mice. , 2010, Investigative ophthalmology & visual science.

[12]  Yimin Shen,et al.  Mouse experimental myopia has features of primate myopia. , 2010, Investigative ophthalmology & visual science.

[13]  Jianhua Wang,et al.  The development of the refractive status and ocular growth in C57BL/6 mice. , 2008, Investigative ophthalmology & visual science.

[14]  Yimin Shen,et al.  Analysis of postnatal eye development in the mouse with high-resolution small animal magnetic resonance imaging. , 2010, Investigative ophthalmology & visual science.

[15]  Yimin Shen,et al.  Genetic Background Modulates Refractive Eye Development And Susceptibility To Myopia In The Mouse , 2012 .

[16]  A. Hughes,et al.  A schematic eye for the rat , 1979, Vision Research.

[17]  David R. Williams,et al.  Optical properties of the mouse eye , 2011, Biomedical optics express.

[18]  F. Schaeffel,et al.  Mathematical model of emmetropization in the chicken. , 1988, Journal of the Optical Society of America. A, Optics and image science.

[19]  P. E. Hallett,et al.  Aspheric curvatures, refractive indices and chromatic aberration for the rat eye , 1983, Vision Research.

[20]  Robert W. Williams,et al.  High susceptibility to experimental myopia in a mouse model with a retinal on pathway defect. , 2008, Investigative ophthalmology & visual science.

[21]  Tatiana V. Tkatchenko,et al.  Ketamine–xylazine anesthesia causes hyperopic refractive shift in mice , 2010, Journal of Neuroscience Methods.

[22]  J. Qu,et al.  Relative Axial Myopia Induced by Prolonged Light Exposure in C57BL/6 Mice , 2010, Photochemistry and photobiology.

[23]  P. E. Hallett,et al.  A schematic eye for the mouse, and comparisons with the rat , 1985, Vision Research.

[24]  Yimin Shen,et al.  Photopic visual input is necessary for emmetropization in mice. , 2013, Experimental eye research.

[25]  A. Hughes,et al.  An analytic, gradient index schematic lens and eye for the rat which predicts aberrations for finite pupils , 1981, Vision Research.

[26]  Richard A Stone,et al.  Investigating mechanisms of myopia in mice. , 2013, Experimental eye research.