Serum Antibodies to Helicobacter pylori and its Heat‐Shock Protein 60 Correlate with the Response of Gastric Mucosa‐Associated Lymphoid Tissue Lymphoma to Eradication of H. pylori

Background and aims.  Eradication of Helicobacter pylori leads to regression of mucosa‐associated lymphoid tissue (MALT) lymphomas. In this study, we measured serum antibodies to H. pylori and H. pylori‐recombinant heat‐shock protein 60 (rHSP60) in patients with gastric MALT lymphoma to determine whether humoral immune responses to the bacterial antigens correlate with the efficacy of eradication therapy.

[1]  K. Yokota,et al.  Outcome of patients with inconsistent results from 13C-urea breath test and bacterial culture at the time of assessment of Helicobacter pylori eradication therapy in Japan. , 2003, Hepato-gastroenterology.

[2]  T. Molina,et al.  T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication. , 2001, Gastroenterology.

[3]  M. Asaka,et al.  Immunoglobulin G1 Antibody Response toHelicobacter pylori Heat Shock Protein 60 Is Closely Associated with Low-Grade Gastric Mucosa-Associated Lymphoid Tissue Lymphoma , 2001, Clinical Diagnostic Laboratory Immunology.

[4]  M. Seto,et al.  API2-MALT1 chimeric transcript is a predictive marker for the responsiveness of H. pylori eradication treatment in low-grade gastric MALT lymphoma. , 2001, Gastroenterology.

[5]  Y. Atomi,et al.  Endoscopic sphincterotomy for bile duct stones in very elderty patients (≥90 years) , 2001 .

[6]  T. Molina,et al.  Predictive factors for regression of gastric MALT lymphoma after anti-Helicobacter pyloritreatment , 2001, Gut.

[7]  Ming-Qing Du,et al.  Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy , 2001, The Lancet.

[8]  T. Akagi,et al.  Gastric ulcers in SCID mice induced by Helicobacter pylori infection after transplanting lymphocytes from patients with gastric lymphoma. , 1999, Gastroenterology.

[9]  K. Yokota,et al.  Antibodies to human gastric epithelial cells and heat shock protein 60 in Helicobacter pylori positive mucosa associated lymphoid tissue lymphoma , 1999, Gut.

[10]  小林 計太.  Detection of Helicobacter pylori- associated antigen and heat shock protein 60 on follicular dendritic cells in the germinal centres of low-grade B-cell lymphoma of gastric mucosa-associated lymphoid tissue(MALT). , 1998 .

[11]  M. Stolte,et al.  Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging. MALT Lymphoma Study Group. , 1997, Gastroenterology.

[12]  G. Zamboni,et al.  Diagnosis and posttreatment follow-up of Helicobacter pylori-positive gastric lymphoma of mucosa-associated lymphoid tissue: histology, polymerase chain reaction, or both? , 1996, Blood.

[13]  D. Jong,et al.  Role of Helicobacter pylori eradication in high-grade MALT lymphoma , 1995, The Lancet.

[14]  M. Stolte,et al.  Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection , 1995, The Lancet.

[15]  F. Cavalli,et al.  Eradication of Helicobacter pylori Infection in Primary Low-Grade Gastric Lymphoma of Mucosa-Associated Lymphoid Tissue , 1995, Annals of Internal Medicine.

[16]  H Stein,et al.  A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. , 1994, Blood.

[17]  R Fischer,et al.  Helicobacter pylori gastritis and primary gastric non-Hodgkin's lymphomas. , 1994, Journal of clinical pathology.

[18]  D. Tompkins,et al.  Systemic and mucosal humoral responses to Helicobacter pylori in gastric cancer. , 1993, Gut.

[19]  T. C. Diss,et al.  Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori , 1993, The Lancet.

[20]  R. Rappuoli,et al.  The Hsp60 protein of Helicobacter pylori: structure and immune response in patients with gastroduodenal diseases , 1993, Molecular microbiology.

[21]  J. Crabtree,et al.  Helicobacter pylori, gastritis, and peptic ulceration in the elderly. , 1992, Journal of Clinical Pathology.

[22]  H. Goossens,et al.  Evaluation of a commercially available second-generation immunoglobulin G enzyme immunoassay for detection of Helicobacter pylori infection , 1992, Journal of clinical microbiology.

[23]  W. Karnes,et al.  Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. , 1991, Gastroenterology.

[24]  D. Newell,et al.  Estimation of prevalence of Helicobacter pylori infection in an asymptomatic elderly population comparing [14C] urea breath test and serology. , 1991, Journal of clinical pathology.

[25]  P. Isaacson,et al.  A genotypic study of low grade B‐cell lymphomas, including lymphomas of mucosa associated lymphoid tissue (MALT) , 1990, The Journal of pathology.

[26]  D. Graham,et al.  A sensitive and specific serologic test for detection of Campylobacter pylori infection. , 1989, Gastroenterology.

[27]  P. Isaacson,et al.  Malignant lymphoma of mucosa‐associated lymphoid tissue. A distinctive type of B‐cell lymphoma , 1983, Cancer.

[28]  K. Musshoff.  [Clinical staging classification of non-Hodgkin's lymphomas (author's transl)]. , 1977, Strahlentherapie.

[29]  A. Soweid,et al.  Predictive value of endoscopic ultrasonography for regression of gastric low grade and high grade MALT lymphomas after eradication of Helicobacter pylori. , 2002, Gastrointestinal endoscopy.