Pharmacokinetics and tissue residue of enrofloxacin in healthy, Eimeria-infected broiler chickens and those pre-treated with amprolium and toltrazuril

ABSTRACT The pharmacokinetics of enrofloxacin was compared in healthy chickens, Eimeria infected chickens and in Eimeria infected chickens pre-treated with amprolium or toltrazuril following a single IV and oral administration at dose 10 mg/kg. The blood samples were taken after administration at different time intervals (5 min to 24 hours) to determine the pharmacokinetic parameters of enrofloxacin. The different concentrations of enrofloxacin were determined by using HPLC assay method. Serum concentrations versus time were analysed by a non-compartmental method. The results explored a significant decrease in serum concentrations of enrofloxacin at different time intervals and a significant change in pharmacokinetic profiles in Eimeria infected chickens compared with those values in healthy chickens whereas, amprolium improves these values. Toltrazuril leads to a significant decrease in enrofloxacin concentrations compared with infected non-treated chickens. Multiple-dose study revealed a longer withdrawal period of enrofloxacin in infected non-treated and infected chickens pre-treated with amprolium compared with the healthy group.

[1]  M. Świtała,et al.  The influence of age and body weight gain on enrofloxacin pharmacokinetics in turkeys-Allometric approach to dose optimization. , 2019, Journal of veterinary pharmacology and therapeutics.

[2]  M. Hossain,et al.  Pharmacokinetic and pharmacodynamic integration of enrofloxacin against Salmonella Enteritidis after administering to broiler chicken by per-oral and intravenous routes , 2019, Journal of veterinary science.

[3]  M. Elbadawy,et al.  Pharmacokinetics of difloxacin in Japanese quails (Coturnix japonica) after single intravenous and oral administration. , 2019, Research in veterinary science.

[4]  Zhiqiang Wang,et al.  In vivo pharmacokinetic/Pharmacodynamic modeling of Enrofloxacin against Escherichia coli in broiler chickens , 2018, BMC Veterinary Research.

[5]  G. M. Ahmed,et al.  Pharmacokinetics aspects and tissue residues of Marbofloxacin in healthy and Mycoplasma gallisepticum–infected chickens , 2017 .

[6]  L. Lashev,et al.  Pharmacokinetics of enrofloxacin and marbofloxacin in Japanese quails and common pheasants , 2015, British poultry science.

[7]  M. Aboubakr,et al.  Comparative Pharmacokinetics of Levofloxacin in Healthy and Renal Damaged Muscovy Ducks following Intravenous and Oral Administration , 2014, Veterinary medicine international.

[8]  M. Aboubakr,et al.  Bioavailability and pharmacokinetic profile of levofloxacin following intravenous, intramuscular and oral administration in turkeys , 2014, British poultry science.

[9]  A. Latif,et al.  Influence of amprolium and toltrazuril on the disposition kinetics of levofloxacin in broiler chickens , 2013 .

[10]  M. Aboubakr.  Evaluation of bioequivalence of two enrofloxacin formulations after intramuscular administration in goats , 2013 .

[11]  M. Valle,et al.  Single and Multiple Pharmacokinetics of Enrofloxacin and Ciprofloxacinin Pigs , 2013 .

[12]  M. Aboubakr.  Pharmacokinetics of levofloxacin in Japanese quails (Coturnix japonica) following intravenous and oral administration , 2012, British poultry science.

[13]  S. Arabia,et al.  Effect of a selected rice bran extract and a chitin synthesis inhibitor on viability of eggs of the house fly Musca domestica Linnaeus. , 2012 .

[14]  H. A. El-Banna,et al.  Comparative bioequivalence study of three formulations of enrofloxacin in sheep. , 2011, Drug metabolism letters.

[15]  L. Al-Anati,et al.  Effect of Flunixin on the Disposition of Enrofloxacin in Calves , 2011 .

[16]  F. Velkers,et al.  Quantification of Eimeria acervulina in faeces of broilers: comparison of McMaster oocyst counts from 24h faecal collections and single droppings to real-time PCR from cloacal swabs. , 2010, Veterinary parasitology.

[17]  A. Goudah.  Pharmacokinetics and tissue residues of moxifloxacin in broiler chickens , 2009, British poultry science.

[18]  J. Shim,et al.  Characterization of the pharmacokinetic disposition of levofloxacin in stallions after intravenous and intramuscular administration. , 2008, Journal of veterinary pharmacology and therapeutics.

[19]  A. Daugschies,et al.  Control of Coccidiosis due to Eimeria bovis and Eimeria zuernii in Calves with Toltrazuril under Field Conditions in Comparison with Diclazuril and Untreated Controls , 2007, Parasitology Research.

[20]  F. Reyes,et al.  Enrofloxacin assay validation and pharmacokinetics following a single oral dose in chickens. , 2006, Journal of veterinary pharmacology and therapeutics.

[21]  S. Yanev,et al.  Pharmacokinetics of Enrofloxacin and Its Metabolite Ciprofloxacin in Male and Female Turkeys following Intravenous and Oral Administration , 2006, Veterinary Research Communications.

[22]  L. Lashev,et al.  Pharmacokinetics and PK/PD modelling of enrofloxacin in Meleagris gallopavo and Gallus domesticus , 2004 .

[23]  K. A. El-Sooud.  Influence of albendazole on the disposition kinetics and milk antimicrobial equivalent activity of enrofloxacin in lactating goats. , 2003 .

[24]  A. Daugschies,et al.  Parasitological and morphological findings in porcine isosporosis after treatment with symmetrical triazintriones , 2003, Parasitology Research.

[25]  Azza Ali Taha,et al.  Disposition kinetics of enrofloxacin (Baytril 5%) in sheep and goats following intravenous and intramuscular injection using a microbiological assay. , 2002, Research in veterinary science.

[26]  A. M. Abd el-aty,et al.  Pharmacokinetics of difloxacin in goats. , 2002, DTW. Deutsche tierarztliche Wochenschrift.

[27]  A. Harder,et al.  Chemotherapeutic approaches to protozoa: Coccidiae – current level of knowledge and outlook , 2001, Parasitology Research.

[28]  L. H. Sumano,et al.  Bioequivalence of four preparations of enrofloxacin in poultry. , 2001, Journal of veterinary pharmacology and therapeutics.

[29]  A. Harder,et al.  Chemotherapeutic approaches to protozoa: Haemosporina – current level of knowledge and outlook , 2001, Parasitology Research.

[30]  G. Greif.  Immunity to coccidiosis after treatment with toltrazuril , 2000, Parasitology Research.

[31]  O. Al-Shaha,et al.  Plasma and respiratory tissues levels of three fluoroquinolones in layer chicks. , 2000 .

[32]  G. A. Soliman.  Tissue distribution and disposition kinetics of enrofloxacin in healthy and E. coli infected broilers. , 2000, DTW. Deutsche tierarztliche Wochenschrift.

[33]  A. Anadón,et al.  Pharmacokinetic variables and tissue residues of enrofloxacin and ciprofloxacin in healthy pigs. , 1999, American journal of veterinary research.

[34]  M. Kietzmann,et al.  Comparative study of the plasma pharmacokinetics and tissue concentrations of danofloxacin and enrofloxacin in broiler chickens. , 1999, Journal of veterinary pharmacology and therapeutics.

[35]  W. Black,et al.  Pharmacokinetics of enrofloxacin given by the oral, intravenous and intramuscular routes in broiler chickens. , 1999, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[36]  F. Soliman,et al.  Pharmacokinetic evaluation of enrofloxacin in chickens. , 1997, British poultry science.

[37]  A. Ramadan,et al.  Anticoccidial efficacy of toltrazuril and halofuginone against Eimeria tenella infection in broiler chickens in Egypt. , 1997, Research in veterinary science.

[38]  D. Boothe,et al.  Disposition of single-dose oral enrofloxacin in the horse. , 1996, Journal of veterinary pharmacology and therapeutics.

[39]  S. Bertini,et al.  Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intravenous and intramuscular administrations in sheep. , 1996, American journal of veterinary research.

[40]  R. Sweeney,et al.  Pharmacokinetics of enrofloxacin in adult horses and concentration of the drug in serum, body fluids, and endometrial tissues after repeated intragastrically administered doses. , 1996, American journal of veterinary research.

[41]  J. McClure,et al.  Pharmacokinetics of enrofloxacin in clinically normal dogs and mice and drug pharmacodynamics in neutropenic mice with Escherichia coli and staphylococcal infections. , 1995, American journal of veterinary research.

[42]  A. Anadón,et al.  Pharmacokinetics and residues of enrofloxacin in chickens. , 1995, American journal of veterinary research.

[43]  P. Dowling.  Antimicrobial Therapy in Veterinary Medicine, 2nd ed. , 1995 .

[44]  S. Giguère,et al.  Antimicrobial therapy in veterinary medicine , 1994 .

[45]  Brooks Dl,et al.  Pharmacokinetic properties of enrofloxacin in rabbits. , 1991 .

[46]  S. Youssef,et al.  Metabolic behaviour and tissue distribution of nalidixic acid in chickens. , 1991, DTW. Deutsche tierarztliche Wochenschrift.

[47]  J. Babish,et al.  Pharmacokinetic properties of enrofloxacin in rabbits. , 1991, American journal of veterinary research.

[48]  Jerome J. Schentag.  Correlation of pharmacokinetic parameters to efficacy of antibiotics: relationships between serum concentrations, MIC values, and bacterial eradication in patients with gram-negative pneumonia. , 1990, Scandinavian journal of infectious diseases. Supplementum.