Self-powered implantable electronic-skin for in situ analysis of urea/uric-acid in body fluids and the potential applications in real-time kidney-disease diagnosis.

As the concentration of different biomarkers in human body fluids are an important parameter of chronic disease, wearable biosensors for in situ analysis of body fluids with high sensitivity, real-time detection, flexibility and biocompatibility have significant potential therapeutic applications. In this paper, a flexible self-powered implantable electronic-skin (e-skin) for in situ body fluids analysis (urea/uric-acid) as a real-time kidney-disease diagnoser has been proposed based on the piezo-enzymatic-reaction coupling process of ZnO nanowire arrays. It can convert the mechanical energy of body movements into a piezoelectric impulse, and the outputting piezoelectric signal contains the urea/uric-acid concentration information in body fluids. This piezoelectric-biosensing process does not need an external electricity supply or battery. The e-skin was implanted under the abdominal skin of a mouse and provided in situ analysis of the kidney-disease parameters. These results provide a new approach for developing a self-powered in situ body fluids-analysis technique for chronic-disease diagnosis.

[1]  B. Satirapoj,et al.  Obesity and its relation to chronic kidney disease: A population‐based, cross‐sectional study of a Thai army population and relatives , 2013, Nephrology.

[2]  Shouzhuo Yao,et al.  Rapid and highly-sensitive uric acid sensing based on enzymatic catalysis-induced upconversion inner filter effect. , 2016, Biosensors & bioelectronics.

[3]  John A. Rogers,et al.  Highly Sensitive Skin‐Mountable Strain Gauges Based Entirely on Elastomers , 2012 .

[4]  T. Arie,et al.  Wearable, Human‐Interactive, Health‐Monitoring, Wireless Devices Fabricated by Macroscale Printing Techniques , 2014 .

[5]  G. Beck,et al.  Predictors of the progression of renal disease in the Modification of Diet in Renal Disease Study. , 1997, Kidney international.

[6]  Yan Zhang,et al.  Outputting Olfactory Bionic Electric Impulse by PANI/PTFE/PANI Sandwich Nanostructures and their Application as Flexible, Smelling Electronic Skin , 2016 .

[7]  Sangsig Kim,et al.  Enzyme-free glucose sensors with channels composed of necked ZnO nanoparticles on plastic , 2011 .

[8]  Lili Xing,et al.  Pt/ZnO nanoarray nanogenerator as self-powered active gas sensor with linear ethanol sensing at room temperature , 2014, Nanotechnology.

[9]  Chengkuo Lee,et al.  An intelligent skin based self-powered finger motion sensor integrated with triboelectric nanogenerator , 2016 .

[10]  Jae-Hyuk Ahn,et al.  Electrical biomolecule detection using nanopatterned silicon via block copolymer lithography. , 2014, Small.

[11]  Zhiqiang Gao,et al.  A highly sensitive and selective electrochemical biosensor for direct detection of microRNAs in serum. , 2013, Analytical chemistry.

[12]  Chi-kung Ho,et al.  Waist circumference, body mass index, serum uric acid, blood sugar, and triglyceride levels are important risk factors for abnormal liver function tests in the Taiwanese population , 2012, The Kaohsiung journal of medical sciences.

[13]  Zhong Lin Wang,et al.  Spontaneous Polarization-Induced Nanohelixes, Nanosprings, and Nanorings of Piezoelectric Nanobelts , 2003 .

[14]  Tingting Yang,et al.  Wearable and Highly Sensitive Graphene Strain Sensors for Human Motion Monitoring , 2014 .

[15]  Lili Xing,et al.  The conversion of PN-junction influencing the piezoelectric output of a CuO/ZnO nanoarray nanogenerator and its application as a room-temperature self-powered active H2S sensor , 2014, Nanotechnology.

[16]  T. Trung,et al.  Flexible and Stretchable Physical Sensor Integrated Platforms for Wearable Human‐Activity Monitoringand Personal Healthcare , 2016, Advanced materials.

[17]  Zhong Lin Wang,et al.  Triboelectric active sensor array for self-powered static and dynamic pressure detection and tactile imaging. , 2013, ACS nano.

[18]  Ming Zhou,et al.  Bioelectrochemical interface engineering: toward the fabrication of electrochemical biosensors, biofuel cells, and self-powered logic biosensors. , 2011, Accounts of chemical research.

[19]  Xinyu Xue,et al.  Self-powered electronic-skin for detecting glucose level in body fluid basing on piezo-enzymatic-reaction coupling process , 2016 .

[20]  Kat Austen,et al.  What could derail the wearables revolution? , 2015, Nature.

[21]  Zhong Lin Wang,et al.  Recent Progress in Electronic Skin , 2015, Advanced science.

[22]  R. Oberbauer,et al.  Predictors of new-onset decline in kidney function in a general middle-european population. , 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[23]  B. Shirinzadeh,et al.  A wearable and highly sensitive pressure sensor with ultrathin gold nanowires , 2014, Nature Communications.

[24]  Long Lin,et al.  A Flexible, Stretchable and Shape‐Adaptive Approach for Versatile Energy Conversion and Self‐Powered Biomedical Monitoring , 2015, Advanced materials.

[25]  Yi Shi,et al.  A nanostructured conductive hydrogels-based biosensor platform for human metabolite detection. , 2015, Nano letters.

[26]  Lei Jiang,et al.  Stretchable‐Fiber‐Confined Wetting Conductive Liquids as Wearable Human Health Monitors , 2016 .

[27]  Carmel Majidi,et al.  Rapid Fabrication of Soft, Multilayered Electronics for Wearable Biomonitoring , 2016 .

[28]  T. Yipintsoi,et al.  Risk factors for development of decreased kidney function in a southeast Asian population: a 12-year cohort study. , 2005, Journal of the American Society of Nephrology : JASN.

[29]  Dae-Hyeong Kim,et al.  Multifunctional wearable devices for diagnosis and therapy of movement disorders. , 2014, Nature nanotechnology.

[30]  Benjamin C. K. Tee,et al.  Flexible polymer transistors with high pressure sensitivity for application in electronic skin and health monitoring , 2013, Nature Communications.

[31]  Elizabeth Gibney,et al.  The inside story on wearable electronics , 2015, Nature.

[32]  F. Kronenberg,et al.  Uric acid as a risk factor for progression of non-diabetic chronic kidney disease? The Mild to Moderate Kidney Disease (MMKD) Study , 2008, Experimental Gerontology.

[33]  Feng Yan,et al.  Flexible Organic Electrochemical Transistors for Highly Selective Enzyme Biosensors and Used for Saliva Testing , 2015, Advanced materials.

[34]  Zhong Lin Wang,et al.  Electrostatic potential in a bent piezoelectric nanowire. The fundamental theory of nanogenerator and nanopiezotronics. , 2007, Nano letters.

[35]  S. Chadban,et al.  High prevalence of chronic kidney disease in Thailand. , 2008, Kidney international.

[36]  J. Vande Walle,et al.  A devastating case of diarrhea-associated hemolytic uremic syndrome associated with extensive cerebral infarction; why we need to do better , 2018, Acta clinica Belgica.

[37]  Yong Ding,et al.  Semiconducting and Piezoelectric Oxide Nanostructures Induced by Polar Surfaces , 2004 .

[38]  Sam Emaminejad,et al.  Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis , 2016, Nature.

[39]  Daoben Zhu,et al.  Ultra-Sensitivity Glucose Sensor Based on Field Emitters , 2009, Nanoscale research letters.

[40]  Benjamin C. K. Tee,et al.  25th Anniversary Article: The Evolution of Electronic Skin (E‐Skin): A Brief History, Design Considerations, and Recent Progress , 2013, Advanced materials.

[41]  Zhong Lin Wang,et al.  Self-powered nanowire devices. , 2010, Nature nanotechnology.

[42]  Lili Xing,et al.  Room-temperature self-powered ethanol sensing of a Pd/ZnO nanoarray nanogenerator driven by human finger movement. , 2014, Nanoscale.

[43]  Lili Xing,et al.  Core–Shell In2O3/ZnO Nanoarray Nanogenerator as a Self-Powered Active Gas Sensor with High H2S Sensitivity and Selectivity at Room Temperature , 2014 .

[44]  Seung Hwan Ko,et al.  A Hyper‐Stretchable Elastic‐Composite Energy Harvester , 2015, Advanced materials.

[45]  Joseph Wang,et al.  A wearable chemical–electrophysiological hybrid biosensing system for real-time health and fitness monitoring , 2016, Nature Communications.

[46]  T. Sun,et al.  Portable urea biosensor based on the extended-gate field effect transistor , 2003 .

[47]  Caofeng Pan,et al.  A Single ZnO Nanofiber-Based Highly Sensitive Amperometric Glucose Biosensor , 2010 .

[48]  Guang Zhu,et al.  Flexible high-output nanogenerator based on lateral ZnO nanowire array. , 2010, Nano letters.

[49]  G. Cao,et al.  A Self‐Charging Power Unit by Integration of a Textile Triboelectric Nanogenerator and a Flexible Lithium‐Ion Battery for Wearable Electronics , 2015, Advanced materials.

[50]  Lili Wang,et al.  An ultra-sensitive and rapid response speed graphene pressure sensors for electronic skin and health monitoring , 2016 .

[51]  P. Lugli,et al.  Enzyme assays using sensor arrays based on ion-selective carbon nanotube field-effect transistors. , 2016, Biosensors & bioelectronics.

[52]  Xinyu Xue,et al.  Portable room-temperature self-powered/active H2 sensor driven by human motion through piezoelectric screening effect , 2014 .

[53]  Larry A. Nagahara,et al.  A Conducting Polymer Nanojunction Sensor for Glucose Detection , 2004 .

[54]  Xuewen Wang,et al.  Silk‐Molded Flexible, Ultrasensitive, and Highly Stable Electronic Skin for Monitoring Human Physiological Signals , 2014, Advanced materials.