Invited Article: Mask-modulated lensless imaging with multi-angle illuminations

The use of multiple diverse measurements can make lensless phase retrieval more robust. Conventional diversity functions include aperture diversity, wavelength diversity, translational diversity, and defocus diversity. Here we discuss a lensless imaging scheme that employs multiple spherical-wave illuminations from a light-emitting diode array as diversity functions. In this scheme, we place a binary mask between the sample and the detector for imposing support constraints for the phase retrieval process. This support constraint enforces the light field to be zero at certain locations and is similar to the aperture constraint in Fourier ptychographic microscopy. We use a self-calibration algorithm to correct the misalignment of the binary mask. The efficacy of the proposed scheme is first demonstrated by simulations where we evaluate the reconstruction quality using mean square error and structural similarity index. The scheme is then experimentally tested by recovering images of a resolution target and biological samples. The proposed scheme may provide new insights for developing compact and large field-of-view lensless imaging platforms. The use of the binary mask can also be combined with other diversity functions for better constraining the phase retrieval solution space. We provide the open-source implementation code for the broad research community.

[1]  Leslie J. Allen,et al.  Phase retrieval from series of images obtained by defocus variation , 2001 .

[2]  Jianqiang Zhu,et al.  Ptychographic microscopy via wavelength scanning , 2017 .

[3]  Jun Tanida,et al.  Single-shot phase imaging with randomized light (SPIRaL). , 2016, Optics express.

[4]  J. Fienup,et al.  Phase retrieval with transverse translation diversity: a nonlinear optimization approach. , 2008, Optics express.

[5]  R. Gerchberg A practical algorithm for the determination of phase from image and diffraction plane pictures , 1972 .

[6]  J. Rodenburg,et al.  Movable aperture lensless transmission microscopy: a novel phase retrieval algorithm. , 2004, Physical review letters.

[7]  James R. Fienup,et al.  Reconstruction of a complex-valued object from the modulus of its Fourier transform using a support constraint , 1987 .

[8]  Matthew O. Williams,et al.  Phase retrieval using nonlinear diversity. , 2013, Applied optics.

[9]  Heinz H. Bauschke,et al.  Phase retrieval, error reduction algorithm, and Fienup variants: a view from convex optimization. , 2002, Journal of the Optical Society of America. A, Optics, image science, and vision.

[10]  James R. Fienup,et al.  Optical misalignment sensing and image reconstruction using phase diversity , 1988 .

[11]  Guoan Zheng,et al.  The ePetri dish, an on-chip cell imaging platform based on subpixel perspective sweeping microscopy (SPSM) , 2011, Proceedings of the National Academy of Sciences.

[12]  Guoan Zheng,et al.  Sparsely sampled Fourier ptychography. , 2014, Optics express.

[13]  Siyuan Dong,et al.  Spectral multiplexing and coherent-state decomposition in Fourier ptychographic imaging. , 2014, Biomedical optics express.

[14]  Tomoyoshi Shimobaba,et al.  Band-limited angular spectrum method for numerical simulation of free-space propagation in far and near fields. , 2009, Optics express.

[15]  Franz Pfeiffer,et al.  Ptychography with broad-bandwidth radiation , 2014 .

[16]  James R. Fienup,et al.  Joint estimation of object and aberrations by using phase diversity , 1992 .

[17]  Vicente Micó,et al.  Improved quantitative phase imaging in lensless microscopy by single-shot multi-wavelength illumination using a fast convergence algorithm. , 2015, Optics express.

[18]  J R Fienup,et al.  Phase retrieval algorithms: a comparison. , 1982, Applied optics.

[19]  J. Rodenburg,et al.  An improved ptychographical phase retrieval algorithm for diffractive imaging. , 2009, Ultramicroscopy.

[20]  Guoan Zheng,et al.  Embedded pupil function recovery for Fourier ptychographic microscopy. , 2014, Optics express.

[21]  Robert A. Gonsalves,et al.  Phase retrieval by differential intensity measurements , 1987 .

[22]  J R Fienup,et al.  Reconstruction of an object from the modulus of its Fourier transform. , 1978, Optics letters.

[23]  Veit Elser Phase retrieval by iterated projections. , 2003, Journal of the Optical Society of America. A, Optics, image science, and vision.

[24]  J. Rodenburg,et al.  Extended ptychography in the transmission electron microscope: possibilities and limitations. , 2011, Ultramicroscopy.

[25]  Laura Waller,et al.  DiffuserCam: Lensless Single-exposure 3D Imaging , 2017, ArXiv.

[26]  J. Rodenburg,et al.  Information multiplexing in ptychography. , 2014, Ultramicroscopy.

[27]  R. Horstmeyer,et al.  Wide-field, high-resolution Fourier ptychographic microscopy , 2013, Nature Photonics.

[28]  Robert A. Gonsalves,et al.  Phase Retrieval And Diversity In Adaptive Optics , 1982 .

[29]  James R Fienup,et al.  Sub-aperture piston phase diversity for segmented and multi-aperture systems. , 2009, Applied optics.

[30]  A. Ozcan,et al.  Synthetic aperture-based on-chip microscopy , 2015, Light: Science & Applications.

[31]  J. Rodenburg Ptychography and Related Diffractive Imaging Methods , 2008 .

[32]  G. Pedrini,et al.  Phase retrieval using multiple illumination wavelengths. , 2008, Optics letters.

[33]  Derek Tseng,et al.  Compact, light-weight and cost-effective microscope based on lensless incoherent holography for telemedicine applications. , 2010, Lab on a chip.

[34]  Yonina C. Eldar,et al.  Phase Retrieval via Matrix Completion , 2011, SIAM Rev..

[35]  Shoham Sabach,et al.  Proximal Heterogeneous Block Implicit-Explicit Method and Application to Blind Ptychographic Diffraction Imaging , 2015, SIAM J. Imaging Sci..