Angiomatoid fibrous histiocytoma: a case report and review of the literature.

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor most commonly occurring in children, adolescents, and young adults. Clinically and radiographically the lesion is easily confused with a hematoma, soft tissue hemangioma, or malignant fibrous histiocytoma. While the lesion is rare, due to the potential for local recurrence and metastasis, it is imperative to consider this lesion in the differential diagnosis of a soft tissue mass in a child or adolescent. Here, we present the clinical, radiologic, and pathologic findings of a case of AFH.

[1]  C. Fletcher,et al.  Diagnostic histopathology of tumors , 2013 .

[2]  M. Hickeson,et al.  Angiomatoid fibrous histiocytoma: staging and evaluation of response to therapy with F-18 FDG PET/CT. , 2011, Clinical nuclear medicine.

[3]  C. Gaskin,et al.  Imaging characteristics of angiomatoid fibrous histiocytoma of bone , 2011, Skeletal Radiology.

[4]  P. Park,et al.  Paraspinal malignant ossifying fibromyxoid tumor with spinal involvement , 2010, Journal of clinical neuroscience.

[5]  A. Ajlan,et al.  Angiomatoid Fibrous Histiocytoma: Magnetic Resonance Imaging Appearance in 2 Cases , 2010, Journal of computer assisted tomography.

[6]  A. Mansfield,et al.  Angiomatoid fibrous histiocytoma in a 25-year-old male , 2010, Rare tumors.

[7]  Carlos Cordon-Cardo,et al.  MFH classification: differentiating undifferentiated pleomorphic sarcoma in the 21st Century , 2009, Expert review of anticancer therapy.

[8]  U. Surti,et al.  EWSR1‐CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma , 2007, Genes, chromosomes & cancer.

[9]  C. Fletcher The evolving classification of soft tissue tumours: an update based on the new WHO classification , 2006, Histopathology.

[10]  W. Chan,et al.  MRI of angiomatoid fibrous histiocytoma , 2004, Skeletal Radiology.

[11]  A. D. De Schepper,et al.  Magnetic resonance imaging of soft tissue tumors , 2000, European Radiology.

[12]  M. Miettinen,et al.  Angiomatoid "malignant" fibrous histiocytoma: a clinicopathologic study of 158 cases and further exploration of the myoid phenotype. , 1999, Human pathology.

[13]  M. Tidman,et al.  Aneurysmal fibrous histiocytoma: an unusual variant of cutaneous fibrous histiocytoma , 1999, Journal of the European Academy of Dermatology and Venereology : JEADV.

[14]  J. Griffith,et al.  Angiomatoid malignant fibrous histiocytoma: report of an unusual case with highly aggressive clinical course. , 1998, The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons.

[15]  D. Arber,et al.  Angiomatoid Fibrous Histiocytoma , 1996, Annals of plastic surgery.

[16]  M. Kransdorf,et al.  Benign soft-tissue tumors in a large referral population: distribution of specific diagnoses by age, sex, and location. , 1995, AJR. American journal of roentgenology.

[17]  H. Rosenthal,et al.  From the archives of the AFIP. Musculoskeletal malignant fibrous histiocytoma: radiologic-pathologic correlation. , 1994, Radiographics : a review publication of the Radiological Society of North America, Inc.

[18]  S. Weiss,et al.  Evaluation of CD68 and Other Histiocytic Antigens in Angiomatoid Malignant Fibrous Histiocytoma , 1991, The American journal of surgical pathology.

[19]  C. Fletcher Angiomatoid "malignant fibrous histiocytoma": an immunohistochemical study indicative of myoid differentiation. , 1991, Human pathology.

[20]  Michael J. Costa,et al.  Angiomatoid Malignant Fibrous Histiocytoma: A Follow‐up Study of 108 Cases with Evaluation of Possible Histologic Predictors of Outcome , 1990, The American journal of surgical pathology.

[21]  G. D'costa,et al.  Angiomatoid malignant fibrous histiocytoma. , 1990, Indian Journal of Pathology and Microbiology.

[22]  G. de Rosa,et al.  Angiomatoid malignant fibrous histiocytoma: cytologic, immunohistochemical, ultrastructural, and flow cytometric study of 20 cases. , 1990, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[23]  M. Zlatkin,et al.  Fluid-fluid level: a nonspecific finding in tumors of bone and soft tissue. , 1990, Radiology.

[24]  R. Zarbo,et al.  Immunoprofile of benign and malignant fibrohistiocytic tumors. , 1987, Journal of oral pathology.

[25]  W. Gunn Cancer: Principles and Practice of Oncology , 1982 .

[26]  M. Kyriakos,et al.  Aneurysmal (“Angiomatoid”) fibrous histiocytoma of the skin , 1981, Cancer.

[27]  F. Enzinger Angiomatoid malignant fibrous histiocytoma. A distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm , 1979, Cancer.