Rassf2 overexpression mediated by AAV promotes the supporting cell-to-hair cell transformation in the cochlea

[1]  Huawei Li,et al.  Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti , 2022, npj Regenerative Medicine.

[2]  Chen Zhang,et al.  Ti3C2TxMXene Composite 3D Hydrogel Potentiates mTOR Signaling to Promote the Generation of Functional Hair Cells in Cochlea Organoids , 2022, Advanced science.

[3]  R. Chai,et al.  Hippo/YAP signaling pathway protects against neomycin-induced hair cell damage in the mouse cochlea , 2022, Cellular and Molecular Life Sciences.

[4]  R. Chai,et al.  Knockdown of Foxg1 in Sox9+ supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse utricle , 2020, Aging.

[5]  A. Doetzlhofer,et al.  LIN28B/let-7 control the ability of neonatal murine auditory supporting cells to generate hair cells through mTOR signaling , 2020, Proceedings of the National Academy of Sciences.

[6]  K. Hochedlinger,et al.  Renewed proliferation in adult mouse cochlea and regeneration of hair cells , 2019, Nature Communications.

[7]  A. Edge,et al.  Inner ear organoids: new tools to understand neurosensory cell development, degeneration and regeneration , 2019, Development.

[8]  Guisheng Zhong,et al.  AAV-ie enables safe and efficient gene transfer to inner ear cells , 2019, Nature Communications.

[9]  Jung-Bum Shin,et al.  Mechanisms of Hair Cell Damage and Repair , 2019, Trends in Neurosciences.

[10]  A. Edge,et al.  Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation , 2019, Front. Cell Dev. Biol..

[11]  Shan Sun,et al.  Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea , 2017, Front. Mol. Neurosci..

[12]  Dong Liu,et al.  Autophagy protects auditory hair cells against neomycin-induced damage , 2017, Autophagy.

[13]  Kathleen A. Marshall,et al.  Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial , 2017, The Lancet.

[14]  R. Chai,et al.  Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea , 2017, Front. Mol. Neurosci..

[15]  J. R. Holt,et al.  Generation of inner ear organoids with functional hair cells from human pluripotent stem cells , 2017, Nature Biotechnology.

[16]  J. Karp,et al.  Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells. , 2017, Cell reports.

[17]  J. R. Holt,et al.  A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear , 2017, Nature Biotechnology.

[18]  D. Gaudet,et al.  Long-Term Retrospective Analysis of Gene Therapy with Alipogene Tiparvovec and Its Effect on Lipoprotein Lipase Deficiency-Induced Pancreatitis. , 2016, Human gene therapy.

[19]  R. Chai,et al.  Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea , 2016, Frontiers of Medicine.

[20]  Jean Bennett,et al.  Safety and durability of effect of contralateral-eye administration of AAV2 gene therapy in patients with childhood-onset blindness caused by RPE65 mutations: a follow-on phase 1 trial , 2016, The Lancet.

[21]  S. Bray Notch signalling in context , 2016, Nature Reviews Molecular Cell Biology.

[22]  E. Basch Reply to K. Kroenke et al. , 2016, Journal of Clinical Oncology.

[23]  J. R. Holt,et al.  Functional development of mechanosensitive hair cells in stem cell-derived organoids parallels native vestibular hair cells , 2016, Nature Communications.

[24]  J. Bok,et al.  Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea , 2015, Proceedings of the National Academy of Sciences.

[25]  Shan Sun,et al.  Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway , 2014, Proceedings of the National Academy of Sciences.

[26]  A. Edge,et al.  Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors , 2013, Proceedings of the National Academy of Sciences.

[27]  D. Fekete,et al.  Wnt signaling during cochlear development. , 2013, Seminars in cell & developmental biology.

[28]  Xiaoping Du,et al.  Magnetic Targeted Delivery of Dexamethasone Acetate Across the Round Window Membrane in Guinea Pigs , 2013, Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology.

[29]  Eric J. Liaw,et al.  Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea , 2012, Proceedings of the National Academy of Sciences.

[30]  Hyunsook Kim,et al.  Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice , 2012, The EMBO journal.

[31]  R. Chai,et al.  Dynamic Expression of Lgr5, a Wnt Target Gene, in the Developing and Mature Mouse Cochlea , 2011, Journal of the Association for Research in Otolaryngology.

[32]  L. Hesson,et al.  RASSF2 associates with and stabilizes the proapoptotic kinase MST2 , 2009, Oncogene.

[33]  L. Biesecker,et al.  Hedgehog Signaling Regulates Sensory Cell Formation and Auditory Function in Mice and Humans , 2008, The Journal of Neuroscience.

[34]  E. Zabarovsky,et al.  Epigenetic regulation of the ras effector/tumour suppressor RASSF2 in breast and lung cancer , 2008, Oncogene.

[35]  Huawei Li,et al.  Sonic hedgehog promotes mouse inner ear progenitor cell proliferation and hair cell generation in vitro , 2006, Neuroreport.

[36]  Kohzoh Imai,et al.  The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer. , 2005, Gastroenterology.

[37]  G. Clark,et al.  RASSF2 Is a Novel K-Ras-specific Effector and Potential Tumor Suppressor* , 2003, Journal of Biological Chemistry.

[38]  M. Mulheisen,et al.  Specification of the mammalian cochlea is dependent on Sonic hedgehog. , 2002, Genes & development.

[39]  D. Fekete,et al.  Hair Cells and Supporting Cells Share a Common Progenitor in the Avian Inner Ear , 1998, The Journal of Neuroscience.

[40]  R. Chai,et al.  Hair Cell Regeneration. , 2019, Advances in experimental medicine and biology.

[41]  D. Lim,et al.  Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. , 2010, Biochemical and biophysical research communications.

[42]  E. Selimoğlu,et al.  Aminoglycoside-induced ototoxicity. , 2007, Current pharmaceutical design.

[43]  J. Thomas,et al.  Neomycin ototoxicity. , 1992, American journal of otolaryngology.