DIVE: a data intensive visualization engine

SUMMARY Modern scientific investigation is generating increasingly larger datasets, yet analyzing these data with current tools is challenging. DIVE is a software framework intended to facilitate big data analysis and reduce the time to scientific insight. Here, we present features of the framework and demonstrate DIVE's application to the Dynameomics project, looking specifically at two proteins. AVAILABILITY AND IMPLEMENTATION Binaries and documentation are available at http://www.dynameomics.org/DIVE/DIVESetup.exe.

[1]  William Schroeder,et al.  The Visualization Toolkit: An Object-Oriented Approach to 3-D Graphics , 1997 .

[2]  Valerie Daggett,et al.  DIVE: A Graph-Based Visual-Analytics Framework for Big Data , 2014, IEEE Computer Graphics and Applications.

[3]  A. Fersht,et al.  Structural basis for understanding oncogenic p53 mutations and designing rescue drugs , 2006, Proceedings of the National Academy of Sciences.

[4]  Valerie Daggett,et al.  Protein simulation data in the relational model , 2011, The Journal of Supercomputing.

[5]  M. Ashburner,et al.  Gene Ontology: tool for the unification of biology , 2000, Nature Genetics.

[6]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[7]  G J Williams,et al.  The Protein Data Bank: a computer-based archival file for macromolecular structures. , 1978, Archives of biochemistry and biophysics.

[8]  V. Daggett,et al.  Structural consequences of mutations to the α-tocopherol transfer protein associated with the neurodegenerative disease ataxia with vitamin E deficiency. , 2013, Biochemistry.

[9]  B. Kennedy,et al.  Structural changes to monomeric CuZn superoxide dismutase caused by the familial amyotrophic lateral sclerosis-associated mutation A4V. , 2009, Biophysical journal.

[10]  Avijit Chakrabartty,et al.  Structure, folding, and misfolding of Cu,Zn superoxide dismutase in amyotrophic lateral sclerosis. , 2006, Biochimica et biophysica acta.

[11]  Frank M Boeckler,et al.  Targeted rescue of a destabilized mutant of p53 by an in silico screened drug , 2008, Proceedings of the National Academy of Sciences.

[12]  R Dustin Schaeffer,et al.  Dynameomics: a comprehensive database of protein dynamics. , 2010, Structure.