Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

[1]  P. Calabresi,et al.  Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction , 2023, Cell Death & Disease.

[2]  G. V. Di Prisco,et al.  TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation , 2023, Genome Medicine.

[3]  Yan-Qing Yin,et al.  Cspg4high microglia contribute to microgliosis during neurodegeneration , 2023, Proceedings of the National Academy of Sciences of the United States of America.

[4]  José A Fernández,et al.  3K3A-Activated Protein C Prevents Microglia Activation, Inhibits NLRP3 Inflammasome and Limits Ocular Inflammation , 2022, International journal of molecular sciences.

[5]  Tuan Leng Tay,et al.  Microglia states and nomenclature: A field at its crossroads , 2022, Neuron.

[6]  S. Paganoni,et al.  Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double‐blind, placebo‐controlled trial , 2022, European journal of neurology.

[7]  Xin Li,et al.  A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease , 2022, Science Translational Medicine.

[8]  V. Sossi,et al.  Brain microglia activation and peripheral adaptive immunity in Parkinson’s disease: a multimodal PET study , 2022, Journal of neuroinflammation.

[9]  Jessica E. Young,et al.  Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons. , 2022, Cell stem cell.

[10]  A. Singleton,et al.  Association of a common genetic variant with Parkinson’s disease is mediated by microglia , 2022, Science Translational Medicine.

[11]  B. Cha,et al.  Nilotinib modulates LPS-induced cognitive impairment and neuroinflammatory responses by regulating P38/STAT3 signaling , 2022, Journal of Neuroinflammation.

[12]  G. Taglialatela,et al.  TREM2‐induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology , 2022, Brain pathology.

[13]  R. Yan,et al.  Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance , 2022, Science advances.

[14]  Wei Wang,et al.  Delayed Infiltration of Peripheral Monocyte Contributes to Phagocytosis and Transneuronal Degeneration in Chronic Stroke , 2022, Stroke.

[15]  L. Tsai,et al.  BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1 , 2022, Science advances.

[16]  Ashley R. Jones,et al.  Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3′UTR protect against ALS , 2022, Nature Neuroscience.

[17]  Anonymous,et al.  2022 Alzheimer's disease facts and figures , 2022, Alzheimer's & dementia : the journal of the Alzheimer's Association.

[18]  H. Weiner,et al.  The microbiota restrains neurodegenerative microglia in a model of amyotrophic lateral sclerosis , 2022, Microbiome.

[19]  J Zhang,et al.  Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease. , 2022, Cell metabolism.

[20]  Yafu Yin,et al.  Microglia Polarization From M1 to M2 in Neurodegenerative Diseases , 2022, Frontiers in Aging Neuroscience.

[21]  M. Mattson,et al.  TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration , 2021, Nature Neuroscience.

[22]  Qizhi Zhang,et al.  Precise gene delivery systems with detachable albumin shell remodeling dysfunctional microglia by TREM2 for treatment of Alzheimer's disease. , 2021, Biomaterials.

[23]  H. Liao,et al.  Nogo receptor impairs the clearance of fibril amyloid‐β by microglia and accelerates Alzheimer’s‐like disease progression , 2021, Aging cell.

[24]  Hyun-Jeong Yang,et al.  Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia , 2021, Frontiers in Pharmacology.

[25]  M. Meyer-Luehmann,et al.  Microglia contribute to the propagation of Aβ into unaffected brain tissue , 2021, Nature Neuroscience.

[26]  T. Guilarte,et al.  Imaging neuroinflammation with TSPO: A new perspective on the cellular sources and subcellular localization. , 2021, Pharmacology & therapeutics.

[27]  M. Prinz,et al.  Microglia: Immune and non-immune functions. , 2021, Immunity.

[28]  P. Svenningsson,et al.  Glia Imaging Differentiates Multiple System Atrophy from Parkinson's Disease: A Positron Emission Tomography Study with [11C]PBR28 and Machine Learning Analysis , 2021, Movement disorders : official journal of the Movement Disorder Society.

[29]  M. Keshavarz,et al.  The Effect of Spironolactone on β-amyloid-Induced Memory Impairment in Male Rats: The Role of Microglial Inhibition , 2021, Advanced pharmaceutical bulletin.

[30]  C. Balducci,et al.  A critical appraisal of tau‐targeting therapies for primary and secondary tauopathies , 2021, Alzheimer's & dementia : the journal of the Alzheimer's Association.

[31]  Xunbin Wei,et al.  Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model , 2021, Light: Science & Applications.

[32]  L. Petrucelli,et al.  Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD , 2021, Cell reports.

[33]  P. Verwaerde,et al.  AZP2006, a new promising treatment for Alzheimer’s and related diseases , 2021, Scientific Reports.

[34]  P. Chan,et al.  Prevalence of Parkinson's Disease: A Community‐Based Study in China , 2021, Movement disorders : official journal of the Movement Disorder Society.

[35]  P. Matthews,et al.  Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology , 2021, bioRxiv.

[36]  H. Ren,et al.  DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65 , 2021, Cell Death & Disease.

[37]  R. Weissleder,et al.  Astrocytic interleukin-3 programs microglia and limits Alzheimer’s disease , 2021, Nature.

[38]  R. Dahlstrom,et al.  Challenges and opportunities , 2021, Foundations of a Sustainable Economy.

[39]  F. Rigo,et al.  Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice , 2021, Proceedings of the National Academy of Sciences.

[40]  Nicholas E. Propson,et al.  Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading , 2021, Proceedings of the National Academy of Sciences.

[41]  D. Holtzman,et al.  Activated microglia mitigate Aβ-associated tau seeding and spreading , 2021, The Journal of experimental medicine.

[42]  Takashi D. Y. Kozai,et al.  Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease , 2021, Nature Communications.

[43]  D. Geschwind,et al.  C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation , 2021, Neuron.

[44]  Je-Wook Yu,et al.  Distinct Features of Brain-Resident Macrophages: Microglia and Non-Parenchymal Brain Macrophages , 2021, Molecules and cells.

[45]  M. Turner,et al.  Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers , 2021, Nature Reviews Neurology.

[46]  A. Nimmerjahn,et al.  Microglia use TAM receptors to detect and engulf amyloid beta plaques , 2021, Nature Immunology.

[47]  Maxim N. Artyomov,et al.  Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia , 2021, Neuron.

[48]  Manuel Buttini,et al.  Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway , 2021, Frontiers in Immunology.

[49]  Cynthia C. Hession,et al.  A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis , 2021, Proceedings of the National Academy of Sciences.

[50]  M. Ericsson,et al.  Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model , 2021, Molecular neurodegeneration.

[51]  Melanie A. Huntley,et al.  Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology , 2021, Neuron.

[52]  L. Grinberg,et al.  Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy , 2021, Nature Communications.

[53]  J. Mulder,et al.  Distinct amyloid-β and tau-associated microglia profiles in Alzheimer’s disease , 2021, Acta Neuropathologica.

[54]  F. Chen,et al.  MicroRNA-146a switches microglial phenotypes to resist the pathological processes and cognitive degradation of Alzheimer's disease , 2021, Theranostics.

[55]  M. Romero-Ramos,et al.  Periphery and brain, innate and adaptive immunity in Parkinson’s disease , 2021, Acta Neuropathologica.

[56]  F. Quintana,et al.  Microglia and Central Nervous System-Associated Macrophages-From Origin to Disease Modulation. , 2021, Annual review of immunology.

[57]  Lin-lin Sun,et al.  Evidence and perspectives of cell senescence in neurodegenerative diseases. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[58]  T. Outeiro,et al.  Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies , 2021, Cells.

[59]  H. Feng,et al.  Diphenyl Diselenide Protects Motor Neurons through Inhibition of Microglia-Mediated Inflammatory Injury in Amyotrophic Lateral Sclerosis. , 2021, Pharmacological research.

[60]  T. Noguchi,et al.  Differentiating Dementia with Lewy Bodies and Alzheimer's Disease by Deep Learning to Structural MRI , 2021, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[61]  Sahithi Attaluri,et al.  Metformin treatment in late middle age improves cognitive function with alleviation of microglial activation and enhancement of autophagy in the hippocampus , 2021, Aging cell.

[62]  V. Papadopoulos,et al.  Cellular sources of TSPO expression in healthy and diseased brain , 2021, European Journal of Nuclear Medicine and Molecular Imaging.

[63]  D. Klenerman,et al.  Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation , 2021, The Journal of biological chemistry.

[64]  Weiqiang Lu,et al.  Antiallergic drug desloratadine as a selective antagonist of 5HT2A receptor ameliorates pathology of Alzheimer's disease model mice by improving microglial dysfunction , 2020, Aging cell.

[65]  Xiangmin Xu,et al.  Microglia Elimination Increases Neural Circuit Connectivity and Activity in Adult Mouse Cortex , 2020, The Journal of Neuroscience.

[66]  Mark Ellisman,et al.  Microglial Gi-dependent dynamics regulate brain network hyperexcitability , 2020, Nature neuroscience.

[67]  P. Edison,et al.  Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here? , 2020, Nature Reviews Neurology.

[68]  Hannah Franklin,et al.  Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models , 2020, Progress in Neurobiology.

[69]  M. Korte,et al.  The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease , 2020, Proceedings of the National Academy of Sciences.

[70]  L. Barbeito,et al.  A Nitroalkene Benzoic Acid Derivative Targets Reactive Microglia and Prolongs Survival in an Inherited Model of ALS via NF-κB Inhibition , 2020, Neurotherapeutics.

[71]  L. Barbeito,et al.  A Nitroalkene Benzoic Acid Derivative Targets Reactive Microglia and Prolongs Survival in an Inherited Model of ALS via NF-κB Inhibition , 2020, Neurotherapeutics.

[72]  D. Bohl,et al.  Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival , 2020, Nature Neuroscience.

[73]  Tim Bartels,et al.  Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases , 2020, Science.

[74]  G. Sancesario,et al.  Modulation of Inflammasome and Pyroptosis by Olaparib, a PARP-1 Inhibitor, in the R6/2 Mouse Model of Huntington’s Disease , 2020, Cells.

[75]  M. Deleidi,et al.  Redefining Microglial Identity in Health and Disease at Single-Cell Resolution. , 2020, Trends in molecular medicine.

[76]  Young T. Hong,et al.  Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy , 2020, Annals of neurology.

[77]  A. Fagan,et al.  Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD Through Multiple Phenotypes. , 2020, Journal of Alzheimer's disease : JAD.

[78]  Michelle K. Cahill,et al.  Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency , 2020, Nature.

[79]  Steven H. Liang,et al.  Recent developments on PET radiotracers for TSPO and their applications in neuroimaging , 2020, Acta pharmaceutica Sinica. B.

[80]  K. Roeder,et al.  APOE and TREM2 regulate amyloid responsive microglia in Alzheimer’s disease , 2020, Acta Neuropathologica.

[81]  T. DeSilva,et al.  Fractalkine-Dependent Microglial Pruning of Viable Oligodendrocyte Progenitor Cells Regulates Myelination , 2020, Cell reports.

[82]  J. Delpech,et al.  P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice , 2020, Molecular Neurodegeneration.

[83]  M. Bogyo,et al.  Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia , 2020, Scientific Reports.

[84]  J. Trojanowski,et al.  Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation , 2020, EMBO molecular medicine.

[85]  D. Perani,et al.  11C‐PK11195 PET–based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis , 2020, Annals of clinical and translational neurology.

[86]  C. Holmes,et al.  Neuroinflammation in dementia with Lewy bodies: a human post-mortem study , 2020, Translational Psychiatry.

[87]  K. Green,et al.  Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain , 2020, EBioMedicine.

[88]  Jinpei Zhou,et al.  DW14006 as a direct AMPKα1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation , 2020, Brain, Behavior, and Immunity.

[89]  J. Priller,et al.  Investigating Microglia in Health and Disease: Challenges and Opportunities. , 2020, Trends in immunology.

[90]  K. Bötzel,et al.  In Vivo Assessment of Neuroinflammation in 4‐Repeat Tauopathies , 2020, medRxiv.

[91]  M. Turner,et al.  Quantitative patterns of motor cortex proteinopathy across ALS genotypes , 2020, Acta Neuropathologica Communications.

[92]  H. Rhinn,et al.  Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer’s disease model , 2020, The Journal of experimental medicine.

[93]  Lijuan Song,et al.  Fasudil inhibits the activation of microglia and astrocytes of transgenic Alzheimer's disease mice via the downregulation of TLR4/Myd88/NF-κB pathway , 2020, Journal of Neuroimmunology.

[94]  Terrance T. Kummer,et al.  Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration. , 2020, The Journal of clinical investigation.

[95]  H. Liao,et al.  The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke , 2020, Journal of Neuroinflammation.

[96]  Peter S. Jones,et al.  Neuroinflammation predicts disease progression in progressive supranuclear palsy , 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

[97]  Young T. Hong,et al.  In vivo PET imaging of neuroinflammation in familial frontotemporal dementia , 2020, Journal of Neurology, Neurosurgery, and Psychiatry.

[98]  C. Limatola,et al.  Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis , 2020, Nature Communications.

[99]  E. Tan,et al.  Historical Perspective: Models of Parkinson’s Disease , 2020, International journal of molecular sciences.

[100]  F. Panza,et al.  Development of disease-modifying drugs for frontotemporal dementia spectrum disorders , 2020, Nature Reviews Neurology.

[101]  Giada Cellot,et al.  BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal synapses , 2020, Molecular Brain.

[102]  M. Simons,et al.  Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region , 2020, EMBO molecular medicine.

[103]  M. Zelaya,et al.  Microglia‐Related Gene Triggering Receptor Expressed in Myeloid Cells 2 (TREM2) Is Upregulated in the Substantia Nigra of Progressive Supranuclear Palsy , 2020, Movement disorders : official journal of the Movement Disorder Society.

[104]  C. Dang,et al.  Inhibitor , 2020, Definitions.

[105]  Andrew B Singleton,et al.  The genetic architecture of Parkinson's disease , 2020, The Lancet Neurology.

[106]  K. Schroder,et al.  The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins , 2020, Glia.

[107]  N. Seyfried,et al.  Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells , 2020, Frontiers in Immunology.

[108]  D. Standaert,et al.  T cell infiltration in both human multiple system atrophy and a novel mouse model of the disease , 2020, Acta Neuropathologica.

[109]  A. Alaimo,et al.  Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer’s disease patients , 2020, GeroScience.

[110]  R. Vandenbroucke,et al.  Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model , 2020, Neurobiology of Aging.

[111]  D. Aarsland,et al.  Postmortem Cortical Transcriptomics of Lewy Body Dementia Reveal Mitochondrial Dysfunction and Lack of Neuroinflammation. , 2020, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[112]  D. Choi,et al.  Targeting the Microglial NLRP3 Inflammasome and Its Role in Parkinson's Disease , 2020, Movement disorders : official journal of the Movement Disorder Society.

[113]  L. Thompson,et al.  Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease. , 2019, Brain : a journal of neurology.

[114]  Bin Zhang,et al.  Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration , 2019, Nature Communications.

[115]  T. Hortobágyi,et al.  Microglia monitor and protect neuronal function through specialized somatic purinergic junctions , 2019, Science.

[116]  E. Musiek,et al.  Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease , 2019, Aging cell.

[117]  S. Duan,et al.  mTOR‐mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP , 2019, Glia.

[118]  Christopher J. Bohlen,et al.  Microglia in Brain Development, Homeostasis, and Neurodegeneration. , 2019, Annual review of genetics.

[119]  A. Schapira,et al.  Parkinson disease , 2019, European journal of neurology.

[120]  S. Sajikumar,et al.  Epigenetic regulation of microglial phosphatidylinositol 3‐kinase pathway involved in long‐term potentiation and synaptic plasticity in rats , 2019, Glia.

[121]  Kang Ho Park,et al.  N,N′-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer’s disease transgenic mice , 2019, Proceedings of the National Academy of Sciences.

[122]  Helmut Kettenmann,et al.  Cien Años de Microglía: Milestones in a Century of Microglial Research , 2019, Trends in Neurosciences.

[123]  L. Buée,et al.  NLRP3 inflammasome activation drives tau pathology , 2019, Nature.

[124]  Sagar,et al.  Mapping microglia states in the human brain through the integration of high-dimensional techniques , 2019, Nature Neuroscience.

[125]  Steffen Jung,et al.  Microglia Biology: One Century of Evolving Concepts , 2019, Cell.

[126]  D. Holtzman,et al.  Alzheimer Disease: An Update on Pathobiology and Treatment Strategies , 2019, Cell.

[127]  Wei Xu,et al.  Efficacy and mechanism of cGAMP to suppress Alzheimer’s disease by elevating TREM2 , 2019, Brain, Behavior, and Immunity.

[128]  Sung Hoon Baik,et al.  A Breakdown in Metabolic Reprogramming Causes Microglia Dysfunction in Alzheimer's Disease. , 2019, Cell metabolism.

[129]  M. Haque,et al.  Thymoquinone prevents neurodegeneration against MPTP in vivo and modulates α-synuclein aggregation in vitro , 2019, Neurochemistry International.

[130]  M. Weiner,et al.  Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease , 2019, Science Translational Medicine.

[131]  L. Brundin,et al.  Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease , 2019, Molecular Neurodegeneration.

[132]  D. Dickson,et al.  The neuropathological diagnosis of Alzheimer’s disease , 2019, Molecular Neurodegeneration.

[133]  Hui-Mei Chen,et al.  Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease , 2019, Nature Communications.

[134]  G. Bormans,et al.  Increased P2X7 Receptor Binding Is Associated With Neuroinflammation in Acute but Not Chronic Rodent Models for Parkinson’s Disease , 2019, Front. Neurosci..

[135]  J. Morris,et al.  Translocator protein in late stage Alzheimer’s disease and Dementia with Lewy bodies brains , 2019, Annals of clinical and translational neurology.

[136]  D. Wilton,et al.  Neuron-Glia Signaling in Synapse Elimination. , 2019, Annual review of neuroscience.

[137]  A. Chiò,et al.  Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial , 2019, Amyotrophic lateral sclerosis & frontotemporal degeneration.

[138]  Manoj Kumar,et al.  INGE GRUNDKE-IQBAL AWARD FOR ALZHEIMER’S RESEARCH: NEUROTOXIC REACTIVE ASTROCYTES ARE INDUCED BY ACTIVATED MICROGLIA , 2019, Alzheimer's & Dementia.

[139]  D. Green,et al.  LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease , 2019, Cell.

[140]  J. Fawcett,et al.  The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function , 2019, Nature Reviews Neuroscience.

[141]  Virginia M. Y. Lee,et al.  TREM2 function impedes tau seeding in neuritic plaques , 2019, Nature Neuroscience.

[142]  R. Barker,et al.  Targeting Huntingtin Expression in Patients with Huntington's Disease. , 2019, The New England journal of medicine.

[143]  Zhiqiang Zhang,et al.  Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF‐&kgr;B signaling pathway in a mouse model of Parkinson's disease , 2019, Life sciences.

[144]  A. Sahebkar,et al.  Effects of Curcumin on Microglial Cells , 2019, Neurotoxicity Research.

[145]  Y. Kurauchi,et al.  Involvement of exosomes in dopaminergic neurodegeneration by microglial activation in midbrain slice cultures. , 2019, Biochemical and biophysical research communications.

[146]  A. Strafella,et al.  New and Old TSPO PET Radioligands for Imaging Brain Microglial Activation in Neurodegenerative Disease , 2019, Current Neurology and Neuroscience Reports.

[147]  Beth Stevens,et al.  Immune Signaling in Neurodegeneration. , 2019, Immunity.

[148]  Huaxi Xu,et al.  Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model , 2019, Nature Communications.

[149]  H. Wulff,et al.  Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease , 2019, Annals of clinical and translational neurology.

[150]  L. Mucke,et al.  Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer’s Disease Model , 2019, Neuron.

[151]  F. Turkheimer,et al.  Widespread microglial activation in multiple system atrophy , 2019, Movement disorders : official journal of the Movement Disorder Society.

[152]  I. Dewachter,et al.  Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo , 2019, Acta Neuropathologica.

[153]  I. Mackenzie,et al.  Review: Neuropathology of non‐tau frontotemporal lobar degeneration , 2019, Neuropathology and applied neurobiology.

[154]  Qingsong Liu,et al.  Sodium rutin ameliorates Alzheimer’s disease–like pathology by enhancing microglial amyloid-β clearance , 2019, Science Advances.

[155]  E. Masliah,et al.  Oligodendroglial α‐synucleinopathy‐driven neuroinflammation in multiple system atrophy , 2019, Brain pathology.

[156]  N. Chen,et al.  Nurr1: A vital participant in the TLR4-NF-κB signal pathway stimulated by α-synuclein in BV-2 cells , 2019, Neuropharmacology.

[157]  L. Passamonti,et al.  Neuroinflammation and Functional Connectivity in Alzheimer's Disease: Interactive Influences on Cognitive Performance , 2019, The Journal of Neuroscience.

[158]  Alan J. Thomas,et al.  Dementia with Lewy bodies: an update and outlook , 2019, Molecular Neurodegeneration.

[159]  Chun Cui,et al.  Neuroprotective effects of Astilbin on MPTP‐induced Parkinson's disease mice: Glial reaction, &agr;‐synuclein expression and oxidative stress , 2019, International immunopharmacology.

[160]  H. Wiendl,et al.  Immune Cell Activation in the Cerebrospinal Fluid of Patients With Parkinson's Disease , 2018, Front. Neurol..

[161]  R. Kahn,et al.  Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry , 2018, Nature Neuroscience.

[162]  Bin Ji,et al.  Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia , 2018, Advanced science.

[163]  Melanie A. Huntley,et al.  Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies , 2018, Neuron.

[164]  J. Ávila,et al.  Dephosphorylated rather than hyperphosphorylated Tau triggers a pro-inflammatory profile in microglia through the p38 MAPK pathway , 2018, Experimental Neurology.

[165]  D. Holtzman,et al.  Loss of TREM2 function increases amyloid seeding but reduces plaque associated ApoE , 2018, Nature Neuroscience.

[166]  Luca Passamonti,et al.  Early microglial activation and peripheral inflammation in dementia with Lewy bodies , 2018, Brain : a journal of neurology.

[167]  J. Julien,et al.  Protective effects of Withania somnifera extract in SOD1G93A mouse model of amyotrophic lateral sclerosis , 2018, Experimental Neurology.

[168]  K. Schroder,et al.  Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice , 2018, Science Translational Medicine.

[169]  S. Salani,et al.  Mitochondrial Dysregulation and Impaired Autophagy in iPSC-Derived Dopaminergic Neurons of Multiple System Atrophy , 2018, Stem cell reports.

[170]  N. Sawamoto,et al.  NLRP3 Inflammasome-Related Proteins Are Upregulated in the Putamen of Patients With Multiple System Atrophy , 2018, Journal of neuropathology and experimental neurology.

[171]  B. Fiebich,et al.  Role of Microglia TLRs in Neurodegeneration , 2018, Front. Cell. Neurosci..

[172]  Steffen Jung,et al.  Genetically enhancing the expression of chemokine domain of CX3CL1 fails to prevent tau pathology in mouse models of tauopathy , 2018, Journal of Neuroinflammation.

[173]  H. Okano,et al.  The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy , 2018, Scientific Reports.

[174]  G. Coppola,et al.  Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy , 2018, Proceedings of the National Academy of Sciences.

[175]  Tuan Leng Tay,et al.  Unique microglia recovery population revealed by single-cell RNAseq following neurodegeneration , 2018, Acta Neuropathologica Communications.

[176]  David J. Brooks,et al.  Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study , 2018, Neurobiology of Disease.

[177]  S. Hickman,et al.  Microglia in neurodegeneration , 2018, Nature Neuroscience.

[178]  D. Baker,et al.  Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline , 2018, Nature.

[179]  B. Ghetti,et al.  Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia , 2018, Cell reports.

[180]  D. Brooks,et al.  Microglial activation correlates in vivo with both tau and amyloid in Alzheimer’s disease , 2018, Brain : a journal of neurology.

[181]  M. Hockin,et al.  Two distinct ontogenies confer heterogeneity to mouse brain microglia , 2018, Development.

[182]  Y. Surova,et al.  Cerebrospinal fluid concentrations of inflammatory markers in Parkinson’s disease and atypical parkinsonian disorders , 2018, Scientific Reports.

[183]  Adam J. Svahn,et al.  Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons , 2018, Acta Neuropathologica.

[184]  D. Praticò,et al.  Learning Impairments, Memory Deficits, and Neuropathology in Aged Tau Transgenic Mice Are Dependent on Leukotrienes Biosynthesis: Role of the cdk5 Kinase Pathway , 2018, Molecular Neurobiology.

[185]  G. Grant,et al.  Epothilone D inhibits microglia-mediated spread of alpha-synuclein aggregates , 2018, Molecular and Cellular Neuroscience.

[186]  M. Beal,et al.  Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy , 2018, Human molecular genetics.

[187]  Yu Tang.  Editorial: Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases , 2018, Front. Aging Neurosci..

[188]  Z. Mari,et al.  Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease , 2018, Nature Medicine.

[189]  E. Janda,et al.  Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson’s Disease? , 2018, Front. Mol. Neurosci..

[190]  D. Praticò,et al.  Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice , 2018, Aging cell.

[191]  I. McKeith,et al.  Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies , 2018, Movement disorders : official journal of the Movement Disorder Society.

[192]  Kevin W. Kelley,et al.  Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development , 2018, Science.

[193]  M. Colonna,et al.  Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism , 2018, The Journal of experimental medicine.

[194]  A. Kalmes,et al.  RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue , 2018, Journal of Neuroinflammation.

[195]  B. Becher,et al.  High‐Dimensional Single‐Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease , 2018, Immunity.

[196]  Y. Aratani.  Myeloperoxidase: Its role for host defense, inflammation, and neutrophil function. , 2018, Archives of biochemistry and biophysics.

[197]  S. Galetta,et al.  Editors' note: Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium , 2018, Neurology.

[198]  K. Danzer,et al.  Release and uptake of pathologic alpha-synuclein , 2018, Cell and Tissue Research.

[199]  A. Cianciulli,et al.  Microglia‐derived extracellular vesicles in Alzheimer's Disease: A double‐edged sword , 2018, Biochemical pharmacology.

[200]  M. Lynch,et al.  Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice , 2018, Brain, Behavior, and Immunity.

[201]  Berislav V. Zlokovic,et al.  Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders , 2018, Nature Reviews Neurology.

[202]  J. Trojanowski,et al.  Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy , 2018, Nature Neuroscience.

[203]  Can Zhang,et al.  Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis , 2018, Scientific Reports.

[204]  Melanie A. Huntley,et al.  Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models. , 2018, Cell reports.

[205]  Yong Ji,et al.  The rs75932628 and rs2234253 polymorphisms of the TREM2 gene were associated with susceptibility to frontotemporal lobar degeneration in Caucasian populations , 2018, Annals of human genetics.

[206]  F. Geissmann,et al.  Yolk sac macrophage progenitors traffic to the embryo during defined stages of development , 2018, Nature Communications.

[207]  W. Poewe,et al.  Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies , 2018, Acta Neuropathologica Communications.

[208]  M. Heneka,et al.  Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease , 2017, Nature.

[209]  D. Praticò,et al.  The direct role of 5-lipoxygenase on tau pathology, synaptic integrity and cognition in a mouse model of tauopathy , 2017, Translational Psychiatry.

[210]  B. Barres,et al.  Microglia and macrophages in brain homeostasis and disease , 2017, Nature Reviews Immunology.

[211]  D. Praticò,et al.  Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy , 2017, Molecular Neurobiology.

[212]  D. Praticò,et al.  Brain 5‐lipoxygenase over‐expression worsens memory, synaptic integrity, and tau pathology in the P301S mice , 2017, Aging cell.

[213]  D. Gomez-Nicola,et al.  Development and maintenance of the brain's immune toolkit: Microglia and non‐parenchymal brain macrophages , 2017, Developmental neurobiology.

[214]  R. Ransohoff,et al.  TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy , 2017, Molecular Neurodegeneration.

[215]  D. Holtzman,et al.  TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy , 2017, Proceedings of the National Academy of Sciences.

[216]  N. Stefanova.  Translational therapies for multiple system atrophy: Bottlenecks and future directions , 2017, Autonomic Neuroscience.

[217]  A. Regev,et al.  Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution , 2017, Cell reports.

[218]  S. Tabrizi,et al.  Therapies targeting DNA and RNA in Huntington's disease , 2017, The Lancet Neurology.

[219]  A. Waisman,et al.  A novel microglial subset plays a key role in myelinogenesis in developing brain , 2017, The EMBO journal.

[220]  J. Levin,et al.  RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease , 2017, Proceedings of the National Academy of Sciences.

[221]  P. S. St George-Hyslop,et al.  TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant , 2017, EMBO molecular medicine.

[222]  C. Haass,et al.  An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function , 2017, EMBO molecular medicine.

[223]  J. Ávila,et al.  Absence of CX3CR1 impairs the internalization of Tau by microglia , 2017, Molecular Neurodegeneration.

[224]  G. Landreth,et al.  TREM2 in Neurodegenerative Diseases , 2017, Molecular Neurodegeneration.

[225]  Jung-Hoon Koo,et al.  Treadmill exercise produces neuroprotective effects in a murine model of Parkinson’s disease by regulating the TLR2/MyD88/NF-κB signaling pathway , 2017, Neuroscience.

[226]  Jeff E. Mold,et al.  The Lifespan and Turnover of Microglia in the Human Brain , 2017, Cell reports.

[227]  R. Baloh,et al.  Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia. , 2017, The Journal of clinical investigation.

[228]  M. Prinz,et al.  Microglia contribute to normal myelinogenesis and to oligodendrocyte progenitor maintenance during adulthood , 2017, Acta Neuropathologica.

[229]  G. Wenning,et al.  Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy , 2017, Molecular Neurodegeneration.

[230]  A. Lang,et al.  Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches , 2017, The Lancet Neurology.

[231]  B. Pakkenberg,et al.  Changes in the cell population in brain white matter in multiple system atrophy , 2017, Movement disorders : official journal of the Movement Disorder Society.

[232]  Paul Edison,et al.  Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer’s disease , 2017, Brain : a journal of neurology.

[233]  R. Donato,et al.  The Pathophysiological Role of Microglia in Dynamic Surveillance, Phagocytosis and Structural Remodeling of the Developing CNS , 2017, Front. Mol. Neurosci..

[234]  B. Tang,et al.  Microglial Activation in the Pathogenesis of Huntington’s Disease , 2017, Front. Aging Neurosci..

[235]  I. Amit,et al.  A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease , 2017, Cell.

[236]  G. Nicolardi,et al.  Vitamin D Treatment Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in an Animal Model of Parkinson’s Disease, Shifting M1 to M2 Microglia Responses , 2017, Journal of Neuroimmune Pharmacology.

[237]  Beth Stevens,et al.  Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice , 2017, Science Translational Medicine.

[238]  Anastasia G. Efthymiou,et al.  Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk , 2017, Molecular Neurodegeneration.

[239]  Anastasia G. Efthymiou,et al.  Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk , 2017, Molecular Neurodegeneration.

[240]  S. Hersch,et al.  KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients , 2017, Proceedings of the National Academy of Sciences.

[241]  R. Tjalkens,et al.  Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity , 2017, Journal of Neuroinflammation.

[242]  D. Mann,et al.  Patterns of Microglial Cell Activation in Alzheimer Disease and Frontotemporal Lobar Degeneration , 2017, Neurodegenerative Diseases.

[243]  M. Colonna,et al.  Microglia Function in the Central Nervous System During Health and Neurodegeneration. , 2017, Annual review of immunology.

[244]  Robert V Farese,et al.  Microglial NFκB-TNFα hyperactivation induces obsessive–compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia , 2017, Proceedings of the National Academy of Sciences.

[245]  Tuan Leng Tay,et al.  A new fate mapping system reveals context-dependent random or clonal expansion of microglia , 2017, Nature Neuroscience.

[246]  Jie Han,et al.  Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases , 2017, The International journal of neuroscience.

[247]  C. Roodveldt,et al.  Extracellular TDP‐43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase‐3/IL‐18 signaling in microglia , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[248]  Tuan Leng Tay,et al.  Microglia across the lifespan: from origin to function in brain development, plasticity and cognition , 2017, The Journal of physiology.

[249]  S. Yao,et al.  NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies , 2017, Front. Cell. Neurosci..

[250]  Alan J. Thomas,et al.  Quantitative neuropathology: an update on automated methodologies and implications for large scale cohorts , 2017, Journal of Neural Transmission.

[251]  Huaxi Xu,et al.  Soluble TREM2 induces inflammatory responses and enhances microglial survival , 2017, The Journal of experimental medicine.

[252]  C. Haass,et al.  Young microglia restore amyloid plaque clearance of aged microglia , 2017, The EMBO journal.

[253]  H. Kettenmann,et al.  Microglia in Physiology and Disease. , 2017, Annual review of physiology.

[254]  A. Romano,et al.  Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target , 2017, Front. Neurosci..

[255]  O. Garaschuk,et al.  Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain , 2017, Cell reports.

[256]  G. Nicolardi,et al.  Vitamin D Treatment Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in an Animal Model of Parkinson’s Disease, Shifting M1 to M2 Microglia Responses , 2016, Journal of Neuroimmune Pharmacology.

[257]  E. Boyden,et al.  Gamma frequency entrainment attenuates amyloid load and modifies microglia , 2016, Nature.

[258]  R. Faull,et al.  Symptom heterogeneity in Huntington's disease correlates with neuronal degeneration in the cerebral cortex , 2016, Neurobiology of Disease.

[259]  G. Sobue,et al.  Exosome secretion is a key pathway for clearance of pathological TDP-43. , 2016, Brain : a journal of neurology.

[260]  E. Boyden,et al.  Gamma frequency entrainment attenuates amyloid load and modifies microglia , 2016, Nature.

[261]  L. Buée,et al.  Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy , 2016, Brain : a journal of neurology.

[262]  J. Palis.  Hematopoietic stem cell‐independent hematopoiesis: emergence of erythroid, megakaryocyte, and myeloid potential in the mammalian embryo , 2016, FEBS letters.

[263]  H. Kettenmann,et al.  The “Big‐Bang” for modern glial biology: Translation and comments on Pío del Río‐Hortega 1919 series of papers on microglia , 2016, Glia.

[264]  T. Möller,et al.  Critical data‐based re‐evaluation of minocycline as a putative specific microglia inhibitor , 2016, Glia.

[265]  Matthew L Senjem,et al.  Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies. , 2016, Brain : a journal of neurology.

[266]  E. Hol,et al.  Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell‐type‐specific , 2016, Glia.

[267]  S. Moestrup,et al.  Anti-Inflammatory Modulation of Microglia via CD163-Targeted Glucocorticoids Protects Dopaminergic Neurons in the 6-OHDA Parkinson's Disease Model , 2016, The Journal of Neuroscience.

[268]  H. Hunt,et al.  New selective glucocorticoid receptor modulators reverse amyloid-β peptide–induced hippocampus toxicity , 2016, Neurobiology of Aging.

[269]  Li-Huei Tsai,et al.  Efficient derivation of microglia-like cells from human pluripotent stem cells , 2016, Nature Medicine.

[270]  Muskan Gupta,et al.  Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study , 2016, Journal of Neuroinflammation.

[271]  Muskan Gupta,et al.  Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study , 2016, Journal of Neuroinflammation.

[272]  R. Ransohoff.  A polarizing question: do M1 and M2 microglia exist? , 2016, Nature Neuroscience.

[273]  D. Schafer,et al.  Microglia: Architects of the Developing Nervous System. , 2016, Trends in cell biology.

[274]  L. Barbeito,et al.  Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis , 2016, Journal of Neuroinflammation.

[275]  W. Streit,et al.  Microglia in dementia with Lewy bodies , 2016, Brain, Behavior, and Immunity.

[276]  S. Ojha,et al.  β-Caryophyllene, a phytocannabinoid attenuates oxidative stress, neuroinflammation, glial activation, and salvages dopaminergic neurons in a rat model of Parkinson disease , 2016, Molecular and Cellular Biochemistry.

[277]  M. Mehler,et al.  Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System , 2016, Trends in Neurosciences.

[278]  Ben A. Barres,et al.  Complement and microglia mediate early synapse loss in Alzheimer mouse models , 2016, Science.

[279]  Michelle K. Cahill,et al.  Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation , 2016, Cell.

[280]  J. Rowe,et al.  Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes , 2016, Neurology.

[281]  S. Linnarsson,et al.  Origin, fate and dynamics of macrophages at central nervous system interfaces , 2016, Nature Immunology.

[282]  D. Bouvier,et al.  High Resolution Dissection of Reactive Glial Nets in Alzheimer’s Disease , 2016, Scientific Reports.

[283]  L. Tan,et al.  A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese , 2016, Neurobiology of Aging.

[284]  Eric E. Smith,et al.  The Prevalence and Incidence of Dementia with Lewy Bodies: a Systematic Review , 2016, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[285]  D. Underhill,et al.  C9orf72 is required for proper macrophage and microglial function in mice , 2016, Science.

[286]  F. Ginhoux,et al.  Tissue-Resident Macrophage Ontogeny and Homeostasis. , 2016, Immunity.

[287]  A. Nimmerjahn,et al.  TAM receptors regulate multiple features of microglial physiology , 2016, Nature.

[288]  R. Rademakers,et al.  Genetics of FTLD: overview and what else we can expect from genetic studies , 2016, Journal of neurochemistry.

[289]  M. Schwaninger,et al.  Protective features of peripheral monocytes/macrophages in stroke. , 2016, Biochimica et biophysica acta.

[290]  N. Chen,et al.  Ginsenoside Rg1 attenuates motor impairment and neuroinflammation in the MPTP-probenecid-induced parkinsonism mouse model by targeting α-synuclein abnormalities in the substantia nigra. , 2016, Toxicology letters.

[291]  C. Gravel,et al.  IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1 , 2016, The Journal of Neuroscience.

[292]  K. Blennow,et al.  Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease , 2016, Molecular Neurodegeneration.

[293]  A. Fagan,et al.  Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status , 2016, Acta Neuropathologica.

[294]  H. Baik,et al.  CB2 receptor activation prevents glial-derived neurotoxic mediator production, BBB leakage and peripheral immune cell infiltration and rescues dopamine neurons in the MPTP model of Parkinson's disease , 2016, Experimental & Molecular Medicine.

[295]  L. Bubacco,et al.  Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells , 2015, Journal of Neuroinflammation.

[296]  J. Ávila,et al.  Direct Evidence of Internalization of Tau by Microglia In Vitro and In Vivo. , 2015, Journal of Alzheimer's disease : JAD.

[297]  D. Praticò,et al.  Pharmacologic Inhibition of 5-Lipoxygenase Improves Memory, Rescues Synaptic Dysfunction, and Ameliorates Tau Pathology in a Transgenic Model of Tauopathy , 2015, Biological Psychiatry.

[298]  G. Guillemin,et al.  Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation , 2015, Front. Cell. Neurosci..

[299]  Yu-hua Chen,et al.  Neuroprotective effects of piperine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model. , 2015, International journal of molecular medicine.

[300]  S. Appel,et al.  TDP-43 activates microglia through NF-κB and NLRP3 inflammasome , 2015, Experimental Neurology.

[301]  V. Haroutunian,et al.  The triggering receptor expressed on myeloid cells 2 (TREM2) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia , 2015, Alzheimer's & Dementia.

[302]  Bente Pakkenberg,et al.  Neocortical Neuronal Loss in Patients with Multiple System Atrophy: A Stereological Study , 2015, Cerebral cortex.

[303]  Jennifer Luebke,et al.  Depletion of microglia and inhibition of exosome synthesis halt tau propagation , 2015, Nature Neuroscience.

[304]  Ainoa Rueda-Zubiaurre,et al.  Endocannabinoids drive the acquisition of an alternative phenotype in microglia , 2015, Brain, Behavior, and Immunity.

[305]  Christer Halldin,et al.  Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. , 2015, Brain : a journal of neurology.

[306]  J. Parisi,et al.  Expanding the spectrum of neuronal pathology in multiple system atrophy. , 2015, Brain : a journal of neurology.

[307]  Alessandra Bertoldo,et al.  The methodology of TSPO imaging with positron emission tomography , 2015, Biochemical Society transactions.

[308]  Frauke Zipp,et al.  Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System. , 2015, Immunity.

[309]  R. J. Mather,et al.  Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications , 2015, Neurotoxicity Research.

[310]  Raymond D. Schellevis,et al.  C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits , 2015, Annals of neurology.

[311]  Paul Edison,et al.  Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia , 2015, Alzheimer's & Dementia.

[312]  Guixiang Xu,et al.  Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. , 2015, Brain : a journal of neurology.

[313]  J. Rothstein,et al.  Rodent Models of Amyotrophic Lateral Sclerosis , 2015, Current protocols in pharmacology.

[314]  Janna H. Neltner,et al.  Disease-related microglia heterogeneity in the hippocampus of Alzheimer’s disease, dementia with Lewy bodies, and hippocampal sclerosis of aging , 2015, Acta Neuropathologica Communications.

[315]  E. Masliah,et al.  Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson’s disease , 2015, Journal of Neuroinflammation.

[316]  K. Cheng,et al.  Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders , 2015, Science Signaling.

[317]  F. Ginhoux,et al.  C-Myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. , 2015, Immunity.

[318]  S. Fumagalli,et al.  The Ischemic Environment Drives Microglia and Macrophage Function , 2015, Front. Neurol..

[319]  M. Hayden,et al.  Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease , 2015, Neurobiology of Disease.

[320]  T. Wieland,et al.  Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia , 2015, Nature Neuroscience.

[321]  J. Sandkühler,et al.  Selective Activation of Microglia Facilitates Synaptic Strength , 2015, The Journal of Neuroscience.

[322]  D. Holtzman,et al.  TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model , 2015, Cell.

[323]  B. Pollock,et al.  In-vivo imaging of grey and white matter neuroinflammation in Alzheimer’s disease: a positron emission tomography study with a novel radioligand, [18F]-FEPPA , 2015, Molecular Psychiatry.

[324]  I. Božić,et al.  Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia , 2015, PloS one.

[325]  Clifford R. Jack,et al.  Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies , 2015, Neurobiology of Aging.

[326]  Bruce R. Rosen,et al.  Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28 , 2015, NeuroImage: Clinical.

[327]  B. Becher,et al.  Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex , 2014, Nature Communications.

[328]  L. Tan,et al.  The role of the LRRK2 gene in Parkinsonism , 2014, Molecular Neurodegeneration.

[329]  G. Simbula,et al.  Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease , 2014, Neurobiology of Disease.

[330]  B. Dubois,et al.  Homozygous TREM2 mutation in a family with atypical frontotemporal dementia , 2014, Neurobiology of Aging.

[331]  S. Rollinson,et al.  Patterns of microglial cell activation in frontotemporal lobar degeneration , 2014, Neuropathology and applied neurobiology.

[332]  N. Zilka,et al.  Microglia display modest phagocytic capacity for extracellular tau oligomers , 2014, Journal of Neuroinflammation.

[333]  Steffen Jung,et al.  Opposing Effects of Membrane-Anchored CX3CL1 on Amyloid and Tau Pathologies via the p38 MAPK Pathway , 2014, The Journal of Neuroscience.

[334]  M. Meyer,et al.  The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice , 2014, The Journal of Steroid Biochemistry and Molecular Biology.

[335]  J. Schapansky,et al.  Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy. , 2014, Human molecular genetics.

[336]  Teng Jiang,et al.  Microglia in Alzheimer's Disease , 2014, BioMed research international.

[337]  P. Lucassen,et al.  Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients , 2014, Acta Neuropathologica Communications.

[338]  Ukpong B. Eyo,et al.  Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus , 2014, The Journal of Neuroscience.

[339]  B. MacVicar,et al.  Activation of Neuronal NMDA Receptors Triggers Transient ATP-Mediated Microglial Process Outgrowth , 2014, The Journal of Neuroscience.

[340]  E. Wei,et al.  Regulation of rotenone-induced microglial activation by 5-lipoxygenase and cysteinyl leukotriene receptor 1 , 2014, Brain Research.

[341]  A. Goate,et al.  Coding variants in TREM2 increase risk for Alzheimer's disease. , 2014, Human molecular genetics.

[342]  J. Godbout,et al.  TGFβ produced by IL‐10 redirected astrocytes attenuates microglial activation , 2014, Glia.

[343]  S. Mandel,et al.  DJ‐1 deficiency triggers microglia sensitivity to dopamine toward a pro‐inflammatory phenotype that is attenuated by rasagiline , 2014, Journal of neurochemistry.

[344]  Brian L. West,et al.  Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain , 2014, Neuron.

[345]  Guy C. Brown,et al.  Microglial phagocytosis of live neurons , 2014, Nature Reviews Neuroscience.

[346]  F. Gage,et al.  Mutant Huntingtin Promotes Autonomous Microglia Activation via Myeloid Lineage-determining Factors Fold Difference from the Mean , 2022 .

[347]  S. Tabrizi,et al.  HTT-lowering reverses Huntington's disease immune dysfunction caused by NFκB pathway dysregulation. , 2014, Brain : a journal of neurology.

[348]  W. Griffin,et al.  Phenotypic profile of alternative activation marker CD163 is different in Alzheimer’s and Parkinson’s disease , 2014, Acta neuropathologica communications.

[349]  Y. Sekino,et al.  Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone , 2014, The Journal of Neuroscience.

[350]  Adriano Chiò,et al.  State of play in amyotrophic lateral sclerosis genetics , 2013, Nature Neuroscience.

[351]  J. Yates,et al.  Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor , 2013, Cell.

[352]  S. Gygi,et al.  Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia , 2013, Nature Neuroscience.

[353]  Young Ho Suh,et al.  DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1 , 2013, Neurobiology of Disease.

[354]  Qian-Qian Jiang,et al.  Expression of Tau40 Induces Activation of Cultured Rat Microglial Cells , 2013, PloS one.

[355]  E. Audinat,et al.  Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory “Barrel” cortex , 2013, Glia.

[356]  H. Neumann,et al.  Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage* , 2013, The Journal of Biological Chemistry.

[357]  H. Hara,et al.  Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental models of amyotrophic lateral sclerosis , 2013, British journal of pharmacology.

[358]  Jie-zhong Yu,et al.  Rho Kinase Inhibitor Fasudil Regulates Microglia Polarization and Function , 2013, Neuroimmunomodulation.

[359]  Jason J. Corneveaux,et al.  Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease , 2013, Neurobiology of Aging.

[360]  W. Rocca,et al.  Incidence and pathology of synucleinopathies and tauopathies related to parkinsonism. , 2013, JAMA neurology.

[361]  R. Petersen,et al.  neurodegeneration : evidence for association of the p . R 47 H variant with frontotemporal dementia and Parkinson ¿ s disease Permalink , 2013 .

[362]  T. Foltynie,et al.  Exenatide and the treatment of patients with Parkinson's disease. , 2013, The Journal of clinical investigation.

[363]  Michel Goedert,et al.  Tau pathology and neurodegeneration , 2013, The Lancet Neurology.

[364]  M. Ishii,et al.  Layer V cortical neurons require microglial support for survival during postnatal development , 2013, Nature Neuroscience.

[365]  B. Pakkenberg,et al.  Screening of Toll-Like Receptors Expression in Multiple System Atrophy Brains , 2013, Neurochemical Research.

[366]  V. Martínez‐Cerdeño,et al.  Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex , 2013, The Journal of Neuroscience.

[367]  E. Masliah,et al.  Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia , 2013, Nature Communications.

[368]  W. Poewe,et al.  Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia , 2013, Glia.

[369]  A Suzumura,et al.  Minocycline selectively inhibits M1 polarization of microglia , 2013, Cell Death and Disease.

[370]  M. Ameloot,et al.  Complex invasion pattern of the cerebral cortex bymicroglial cells during development of the mouse embryo , 2013, Glia.

[371]  A. Kakita,et al.  Alteration of autophagosomal proteins in the brain of multiple system atrophy , 2013, Neurobiology of Disease.

[372]  F. Rosenbauer,et al.  Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways , 2013, Nature Neuroscience.

[373]  A. Singleton,et al.  TREM2 variants in Alzheimer's disease. , 2013, The New England journal of medicine.

[374]  A. Hofman,et al.  Variant of TREM2 associated with the risk of Alzheimer's disease. , 2013, The New England journal of medicine.

[375]  M. Merad,et al.  Regulation of microglia development and homeostasis , 2013, Glia.

[376]  I. Campbell,et al.  IFN Regulatory Factor 8 Is a Key Constitutive Determinant of the Morphological and Molecular Properties of Microglia in the CNS , 2012, PloS one.

[377]  A. Singleton,et al.  Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement. , 2012, JAMA neurology.

[378]  S. Appel,et al.  Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS , 2012, Experimental Neurology.

[379]  M. Zusso,et al.  Regulation of Postnatal Forebrain Amoeboid Microglial Cell Proliferation and Development by the Transcription Factor Runx1 , 2012, The Journal of Neuroscience.

[380]  F. Yasuno,et al.  Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment–dementia converters measured by positron emission tomography with [11C]DAA1106 , 2012, Psychiatry Research: Neuroimaging.

[381]  B. Bhushan,et al.  Suppression of Nuclear Factor-κB Activation and Inflammation in Microglia by Physically Modified Saline* , 2012, The Journal of Biological Chemistry.

[382]  M. Diamond,et al.  IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia , 2012, Nature Immunology.

[383]  J. Trojanowski,et al.  Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis , 2012, PloS one.

[384]  Katherine R. Smith,et al.  Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage. , 2012, American journal of human genetics.

[385]  W. Poewe,et al.  Myeloperoxidase Inhibition Ameliorates Multiple System Atrophy-Like Degeneration in a Transgenic Mouse Model , 2012, Neurotoxicity Research.

[386]  W. Poewe,et al.  Systemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy , 2012, Acta Neuropathologica.

[387]  R. Ransohoff,et al.  Innate immunity in the central nervous system. , 2012, The Journal of clinical investigation.

[388]  J. Winkler,et al.  Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy , 2012, Experimental Neurology.

[389]  C. Richter-Landsberg,et al.  Involvement of Macroautophagy in Multiple System Atrophy and Protein Aggregate Formation in Oligodendrocytes , 2012, Journal of Molecular Neuroscience.

[390]  L. Kaltenbach,et al.  Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons , 2012, Neurobiology of Aging.

[391]  R. Swanson,et al.  Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor , 2012, Journal of Neuroinflammation.

[392]  D. Standaert,et al.  LRRK2 Inhibition Attenuates Microglial Inflammatory Responses , 2012, The Journal of Neuroscience.

[393]  L. Stefanis.  α-Synuclein in Parkinson's disease. , 2012, Cold Spring Harbor perspectives in medicine.

[394]  O. Pascual,et al.  Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission , 2011, Proceedings of the National Academy of Sciences.

[395]  Jianqing Ding,et al.  CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease , 2011, Journal of Neuroinflammation.

[396]  Chandler D. Gatenbee,et al.  Cytokine expression and microglial activation in progressive supranuclear palsy. , 2011, Parkinsonism & related disorders.

[397]  J. Pollard,et al.  Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits , 2011, PloS one.

[398]  David Heckerman,et al.  A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD , 2011, Neuron.

[399]  Bruce L. Miller,et al.  Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS , 2011, Neuron.

[400]  M. Giustetto,et al.  Synaptic Pruning by Microglia Is Necessary for Normal Brain Development , 2011, Science.

[401]  N. Zilka,et al.  Misfolded Truncated Protein τ Induces Innate Immune Response via MAPK Pathway , 2011, The Journal of Immunology.

[402]  K. Tieu,et al.  A guide to neurotoxic animal models of Parkinson's disease. , 2011, Cold Spring Harbor perspectives in medicine.

[403]  W. Poewe,et al.  Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons. , 2011, The American journal of pathology.

[404]  P. Patterson,et al.  The role of IκB kinase complex in the neurobiology of Huntington's disease , 2011, Neurobiology of Disease.

[405]  C. Wiessner,et al.  Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation , 2011, PloS one.

[406]  R. Schwarcz,et al.  Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration , 2011, Cell.

[407]  J. Clarke,et al.  What is a systematic review? , 2011, Evidence Based Nursing.

[408]  S. Finkbeiner.  Huntington's Disease. , 2011, Cold Spring Harbor perspectives in biology.

[409]  H. Adami,et al.  Epidemiology and etiology of Parkinson’s disease: a review of the evidence , 2011, European Journal of Epidemiology.

[410]  C. Ferrari,et al.  Parkinson's Disease and Systemic Inflammation , 2011, Parkinson's disease.

[411]  F. Peri,et al.  Microglia in the developing brain: from immunity to behaviour , 2011, Current Opinion in Neurobiology.

[412]  Yen F. Tai,et al.  Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: A multimodal imaging study , 2011, Human brain mapping.

[413]  Mitsuru Kikuchi,et al.  In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer’s disease , 2011, European Journal of Nuclear Medicine and Molecular Imaging.

[414]  C. Ross,et al.  Huntington's disease: from molecular pathogenesis to clinical treatment , 2011, The Lancet Neurology.

[415]  P. Bickford,et al.  CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease , 2011, Journal of Neuroinflammation.

[416]  M. Beal,et al.  Behavioral deficits and progressive neuropathology in progranulin‐deficient mice: a mouse model of frontotemporal dementia , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[417]  Gerhard Rammes,et al.  Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders , 2010, Nature Reviews Drug Discovery.

[418]  F. Ginhoux,et al.  Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages , 2010, Science.

[419]  G. Enikolopov,et al.  Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. , 2010, Cell stem cell.

[420]  R. Ransohoff,et al.  Regulation of Tau Pathology by the Microglial Fractalkine Receptor , 2010, Neuron.

[421]  C. Verney,et al.  Early microglial colonization of the human forebrain and possible involvement in periventricular white‐matter injury of preterm infants , 2010, Journal of anatomy.

[422]  D. Morgan,et al.  LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice , 2010, Journal of Neuroinflammation.

[423]  W. Ren,et al.  The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: The role of tumor necrosis factor-α , 2010, Brain, Behavior, and Immunity.

[424]  Tian-Le Xu,et al.  Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. , 2010, Brain : a journal of neurology.

[425]  P. Jenner,et al.  A comparison of changes in proteasomal subunit expression in the substantia nigra in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy , 2010, Brain Research.

[426]  D. Oorschot,et al.  Cell loss in the motor and cingulate cortex correlates with symptomatology in Huntington's disease. , 2010, Brain : a journal of neurology.

[427]  C. Iadecola,et al.  Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice , 2010, The Journal of experimental medicine.

[428]  J. Julien,et al.  Extracellular mutant SOD1 induces microglial‐mediated motoneuron injury , 2010, Glia.

[429]  Alexander Gerhard,et al.  Minocycline 1‐year therapy in multiple‐system‐atrophy: Effect on clinical symptoms and [11C] (R)‐PK11195 PET (MEMSA‐trial) , 2010, Movement disorders : official journal of the Movement Disorder Society.

[430]  S. Sakoda,et al.  Roles of Sema4D–Plexin-B1 Interactions in the Central Nervous System for Pathogenesis of Experimental Autoimmune Encephalomyelitis , 2009, The Journal of Immunology.

[431]  N. Cairns,et al.  TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration , 2009, Proceedings of the National Academy of Sciences.

[432]  Í. Azcoitia,et al.  Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity. , 2009, Brain : a journal of neurology.

[433]  E. Brouillet,et al.  Cannabinoid CB2 receptor agonists protect the striatum against malonate toxicity: Relevance for Huntington's disease , 2009, Glia.

[434]  H. Neumann,et al.  Accumulation of tau induced in neurites by microglial proinflammatory mediators , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[435]  D. Dexter,et al.  Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6‐hydroxydopamine model of Parkinson’s disease , 2009, Journal of neurochemistry.

[436]  W. Koek,et al.  WIN55,212‐2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine mouse model of Parkinson’s disease , 2009, The European journal of neuroscience.

[437]  Xiaomin Su,et al.  Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity , 2009, Neurotoxicity Research.

[438]  Marie-Claude Potier,et al.  Classification and basic pathology of Alzheimer disease , 2009, Acta Neuropathologica.

[439]  B. Dubois,et al.  TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration , 2009, Annals of neurology.

[440]  David R Williams,et al.  Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges , 2009, The Lancet Neurology.

[441]  Xun Hu,et al.  Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6 , 2009, Science.

[442]  Z Walker,et al.  Microglial activation and amyloid deposition in mild cognitive impairment , 2009, Neurology.

[443]  A. Salminen,et al.  Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells , 2008, Journal of Neuroimmunology.

[444]  J. Trojanowski,et al.  TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. , 2008, Archives of neurology.

[445]  R. Schmidt,et al.  Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation. , 2008, Brain : a journal of neurology.

[446]  P Sandroni,et al.  Second consensus statement on the diagnosis of multiple system atrophy , 2008, Neurology.

[447]  R. Mark Henkelman,et al.  Three-Dimensional Analysis of Vascular Development in the Mouse Embryo , 2008, PloS one.

[448]  D. Westaway,et al.  Microglial activation in brain lesions with tau deposits: Comparison of human tauopathies and tau transgenic mice TgTauP301L , 2008, Brain Research.

[449]  R. Swanson,et al.  Zinc Triggers Microglial Activation , 2008, The Journal of Neuroscience.

[450]  K. Talbot,et al.  Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS , 2008, Progress in Neurobiology.

[451]  Xun Hu,et al.  TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis , 2008, Science.

[452]  P. Mcgeer,et al.  Glial reactions in Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[453]  M. S. Lee,et al.  Effects of disease duration on the clinical features and brain glucose metabolism in patients with mixed type multiple system atrophy. , 2008, Brain : a journal of neurology.

[454]  Hans Lassmann,et al.  Multiple sclerosis and Alzheimer's disease , 2008, Annals of neurology.

[455]  John D. Lambris,et al.  The Classical Complement Cascade Mediates CNS Synapse Elimination , 2007, Cell.

[456]  H. Mitsumoto,et al.  Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial , 2007, The Lancet Neurology.

[457]  J. Trojanowski,et al.  Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy , 2007, Neuropathology and applied neurobiology.

[458]  W. Poewe,et al.  Microglial activation mediates neurodegeneration related to oligodendroglial α‐synucleinopathy: Implications for multiple system atrophy , 2007, Movement disorders : official journal of the Movement Disorder Society.

[459]  H. Kettenmann,et al.  Microglia: active sensor and versatile effector cells in the normal and pathologic brain , 2007, Nature Neuroscience.

[460]  S. Appel,et al.  Mutant SOD1G93A microglia are more neurotoxic relative to wild‐type microglia , 2007, Journal of neurochemistry.

[461]  M. Lynch,et al.  CD200 Ligand–Receptor Interaction Modulates Microglial Activation In Vivo and In Vitro: A Role for IL-4 , 2007, The Journal of Neuroscience.

[462]  Danielle A. Simmons,et al.  Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease , 2007, Glia.

[463]  C. Verney,et al.  Entry and Distribution of Microglial Cells in Human Embryonic and Fetal Cerebral Cortex , 2007, Journal of neuropathology and experimental neurology.

[464]  Bin Zhang,et al.  Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model , 2007, Neuron.

[465]  Daniel G. Tenen,et al.  Transcription factors in myeloid development: balancing differentiation with transformation , 2007, Nature Reviews Immunology.

[466]  Michael Karin,et al.  Regulation and Function of IKK and IKK-Related Kinases , 2006, Science's STKE.

[467]  S. Melquist,et al.  Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17 , 2006, Nature.

[468]  T. Klockgether,et al.  Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms , 2006, International Journal of Developmental Neuroscience.

[469]  Alexander Hammers,et al.  In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease , 2006, Neurobiology of Disease.

[470]  Alexander Gerhard,et al.  In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in progressive supranuclear palsy , 2006, Movement disorders : official journal of the Movement Disorder Society.

[471]  Alexander Gerhard,et al.  Microglial activation in presymptomatic Huntington's disease gene carriers. , 2005, Brain : a journal of neurology.

[472]  J. Antel,et al.  TLR Signaling Tailors Innate Immune Responses in Human Microglia and Astrocytes1 , 2005, The Journal of Immunology.

[473]  W. Gan,et al.  ATP mediates rapid microglial response to local brain injury in vivo , 2005, Nature Neuroscience.

[474]  T. Möller,et al.  Astrocyte-Derived ATP Induces Vesicle Shedding and IL-1β Release from Microglia1 , 2005, The Journal of Immunology.

[475]  F. Helmchen,et al.  Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo , 2005, Science.

[476]  Belinda Wilson,et al.  Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[477]  Werner Poewe,et al.  Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy. , 2005, The American journal of pathology.

[478]  Mari Yoshida,et al.  Cytokine production of activated microglia and decrease in neurotrophic factors of neurons in the hippocampus of Lewy body disease brains , 2005, Acta Neuropathologica.

[479]  E. Gundelfinger,et al.  Impaired Synaptic Function in the Microglial KARAP/DAP12-Deficient Mouse , 2004, The Journal of Neuroscience.

[480]  Elizabeth L Sampson,et al.  In vivo detection of microglial activation in frontotemporal dementia , 2004, Annals of neurology.

[481]  Alexander Gerhard,et al.  In vivo imaging of microglial activation with [11C](R)‐PK11195 PET in corticobasal degeneration , 2004, Movement disorders : official journal of the Movement Disorder Society.

[482]  K. Wakabayashi,et al.  A quantitative investigation of neuronal cytoplasmic and intranuclear inclusions in the pontine and inferior olivary nuclei in multiple system atrophy , 2004, Neuropathology and applied neurobiology.

[483]  G. Glatting,et al.  Imaging of activated microglia with PET and [11C]PK 11195 in corticobasal degeneration , 2004, Movement disorders : official journal of the Movement Disorder Society.

[484]  F. Turkheimer,et al.  Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study , 2004, Neurobiology of Disease.

[485]  T. Kurotani,et al.  Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia , 2004, Neuropharmacology.

[486]  N. Rooijen,et al.  Microglia Promote the Death of Developing Purkinje Cells , 2004, Neuron.

[487]  T. Siddique,et al.  Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue , 2004, Annals of neurology.

[488]  T. Mizutani,et al.  Microglial Activation Parallels System Degeneration in Multiple System Atrophy , 2004, Journal of neuropathology and experimental neurology.

[489]  Makoto Sawada,et al.  Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains , 2003, Acta Neuropathologica.

[490]  A. Morton,et al.  Microglia density decreases with age in a mouse model of Huntington's disease , 2003, Glia.

[491]  Sarah J Tabrizi,et al.  Models of Parkinson's disease , 2003, Movement disorders : official journal of the Movement Disorder Society.

[492]  S. Barger,et al.  Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway , 2003, The Journal of Neuroscience.

[493]  Bin Liu,et al.  Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention , 2003, Journal of Pharmacology and Experimental Therapeutics.

[494]  Dennis W Dickson,et al.  Dementia with Lewy Bodies: Neuropathology , 2002, Journal of geriatric psychiatry and neurology.

[495]  J. Julien,et al.  Minocycline Slows Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis , 2002, Neurobiology of Disease.

[496]  P. Caroni,et al.  Accumulation of SOD1 Mutants in Postnatal Motoneurons Does Not Cause Motoneuron Pathology or Motoneuron Disease , 2002, The Journal of Neuroscience.

[497]  S. Hoyer,et al.  The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update , 2002, Journal of Neural Transmission.

[498]  S. Appel,et al.  Immune reactivity in a mouse model of familial ALS correlates with disease progression , 2001, Neurology.

[499]  K. Hasegawa,et al.  Distribution and dynamic process of neuronal cytoplasmic inclusion (NCI) in MSA: Correlation of the density of NCI and the degree of involvement of the pontine nuclei , 2001, Neuropathology : official journal of the Japanese Society of Neuropathology.

[500]  Roger N Gunn,et al.  In-vivo measurement of activated microglia in dementia , 2001, The Lancet.

[501]  D. Dickson,et al.  Microglial Activation Parallels System Degeneration in Progressive Supranuclear Palsy and Corticobasal Degeneration , 2001, Journal of neuropathology and experimental neurology.

[502]  H U Rehman,et al.  Multiple system atrophy , 2001, Postgraduate medical journal.

[503]  A. Pramatarova,et al.  Neuron-Specific Expression of Mutant Superoxide Dismutase 1 in Transgenic Mice Does Not Lead to Motor Impairment , 2001, The Journal of Neuroscience.

[504]  B. Fiebich,et al.  Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia , 2001, The Journal of Neuroscience.

[505]  G. Wilkin,et al.  Inflammatory Regulators in Parkinson's Disease: iNOS, Lipocortin-1, and Cyclooxygenases-1 and -2 , 2000, Molecular and Cellular Neuroscience.

[506]  Murray Grossman,et al.  Quantitative neurohistological features of frontotemporal degeneration , 2000, Neurobiology of Aging.

[507]  I. Mackenzie.  Activated microglia in dementia with Lewy bodies , 2000, Neurology.

[508]  G. Halliday,et al.  Cortical inflammation in Alzheimer disease but not dementia with Lewy bodies. , 2000, Archives of neurology.

[509]  Bin Liu,et al.  Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation. , 2000, The Journal of pharmacology and experimental therapeutics.

[510]  Adriana,et al.  Molecular Mechanisms , 1999 .

[511]  Claire-Anne Gutekunst,et al.  Nuclear and Neuropil Aggregates in Huntington’s Disease: Relationship to Neuropathology , 1999, The Journal of Neuroscience.

[512]  W. Streit,et al.  Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[513]  J Q Trojanowski,et al.  Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein , 1998, Annals of neurology.

[514]  M. Gurney,et al.  Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS , 1998 .

[515]  Y. Fukuuchi,et al.  Microglia-specific localisation of a novel calcium binding protein, Iba1. , 1998, Brain research. Molecular brain research.

[516]  D. Maraganore,et al.  Incidence of progressive supranuclear palsy and multiple system atrophy in Olmsted County, Minnesota, 1976 to 1990 , 1997, Neurology.

[517]  Alan C. Evans,et al.  PK11195 binding to the peripheral benzodiazepine receptor as a marker of microglia activation in multiple sclerosis and experimental autoimmune encephalomyelitis , 1997, Journal of neuroscience research.

[518]  Mark Turmaine,et al.  Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation , 1997, Cell.

[519]  S. W. Davies,et al.  Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice , 1996, Cell.

[520]  Y. Agid,et al.  Nitric oxide synthase and neuronal vulnerability in parkinson's disease , 1996, Neuroscience.

[521]  L. Rome,et al.  Stimulation of in vitro myelin synthesis by microglia , 1994, Glia.

[522]  M. Gurney,et al.  Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. , 1994, Science.

[523]  M. Hayden,et al.  The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease , 1993, Nature Genetics.

[524]  M. Demitrack,et al.  Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. , 1992, Brain : a journal of neurology.

[525]  H. Kettenmann,et al.  An immortalized cell line expresses properties of activated microglial cells , 1992, Journal of neuroscience research.

[526]  G. Kreutzberg,et al.  Cultured microglial cells have a distinct pattern of membrane channels different from peritoneal macrophages , 1990, Journal of neuroscience research.

[527]  Peter L. Lantos,et al.  Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome) , 1989, Journal of the Neurological Sciences.

[528]  T. Marunouchi,et al.  Production of tumor necrosis factor-alpha by microglia and astrocytes in culture , 1989, Brain Research.

[529]  N. Quinn,et al.  Multiple system atrophy--the nature of the beast. , 1989, Journal of neurology, neurosurgery, and psychiatry.

[530]  A. Prochiantz,et al.  Brain macrophages synthesize interleukin‐1 and interleukin‐1 mRNAs in vitro , 1988, Journal of neuroscience research.

[531]  P. Mcgeer,et al.  Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains , 1988, Neurology.

[532]  D Giulian,et al.  Characterization of ameboid microglia isolated from developing mammalian brain , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[533]  G. Graveland,et al.  Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease. , 1985, Science.

[534]  M. Ibrahim,et al.  The histochemical identification of microglia. , 1974, Journal of the neurological sciences.

[535]  R. Snow,et al.  Review of the Evidence. , 1964, Science.

[536]  G. Tremblay.  Neuropathology , 1935, Neurology.

[537]  M. Spielmann,et al.  Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-speci fi c neuronal state , 2022 .

[538]  OUP accepted manuscript , 2022, Brain.

[539]  OUP accepted manuscript , 2021, Brain.

[540]  C. Hölscher,et al.  Semaglutide is Neuroprotective and Reduces α-Synuclein Levels in the Chronic MPTP Mouse Model of Parkinson's Disease. , 2019, Journal of Parkinson's disease.

[541]  M. Tremblay,et al.  Morphology of Microglia Across Contexts of Health and Disease. , 2019, Methods in molecular biology.

[542]  M. Heneka,et al.  Microglia in Neurodegenerative Disorders. , 2019, Methods in molecular biology.

[543]  B. Becher,et al.  High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease. , 2018, Immunity.

[544]  Clinical Implications. , 2017, Hypertension.

[545]  J. Götz,et al.  Extracellular Vesicles Containing P301L Mutant Tau Accelerate Pathological Tau Phosphorylation and Oligomer Formation but Do Not Seed Mature Neurofibrillary Tangles in ALZ17 Mice. , 2016, Journal of Alzheimer's disease : JAD.

[546]  D. Standaert,et al.  Role of α-synuclein in inducing innate and adaptive immunity in Parkinson disease. , 2015, Journal of Parkinson's disease.

[547]  Ahmad,et al.  Mechanistic Study , 2015 .

[548]  Eric H Kim,et al.  The Neuropathology of Huntington's Disease. , 2015, Current topics in behavioral neurosciences.

[549]  Murray Grossman,et al.  Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine , 2015, Acta Neuropathologica.

[550]  G. Halliday,et al.  Alpha synuclein in Parkinson's disease , 2014 .

[551]  T. Foltynie,et al.  Motor and cognitive advantages persist 12 months after exenatide exposure in Parkinson's disease. , 2014, Journal of Parkinson's disease.

[552]  J. Dorszewska,et al.  [Alpha-synuclein in Parkinson's disease]. , 2014, Przeglad lekarski.

[553]  R. Maccioni,et al.  Tau oligomers and fibrils induce activation of microglial cells. , 2013, Journal of Alzheimer's disease : JAD.

[554]  D. Perani,et al.  In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease. , 2013, Parkinsonism & related disorders.

[555]  D. Selkoe.  Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.

[556]  Julie A. Schneider,et al.  Evidence for angiogenesis in Parkinson’s disease, incidental Lewy body disease, and progressive supranuclear palsy , 2011, Journal of Neural Transmission.

[557]  A. Reiner,et al.  Genetics and neuropathology of Huntington's disease. , 2011, International review of neurobiology.

[558]  P. Oettgen,et al.  CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson’s disease , 2010, Journal of Neural Transmission.

[559]  J. Trojanowski,et al.  Brain progranulin expression in GRN-associated frontotemporal lobar degeneration , 2009, Acta Neuropathologica.

[560]  Y. Okuno,et al.  PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis , 2008, Nature Genetics.

[561]  D. Mann,et al.  Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis , 2008, Acta Neuropathologica.

[562]  T. Möller,et al.  Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. , 2005, Journal of immunology.

[563]  G. Kreutzberg,et al.  Displacement of synaptic terminals from regenerating motoneurons by microglial cells , 2004, Zeitschrift für Zellforschung und Mikroskopische Anatomie.

[564]  P. Patterson,et al.  Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity. , 2004, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[565]  A. Brownell,et al.  Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease , 2004 .

[566]  P Bailey,et al.  Double Edged Sword , 2002 .

[567]  H. Ichinose,et al.  Cytokines in Parkinson's disease. , 2000, Journal of neural transmission. Supplementum.

[568]  C. Halldin,et al.  A PET study of , 2000, The international journal of neuropsychopharmacology.

[569]  M. Gurney,et al.  Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS. , 1998, Glia.

[570]  D. Rosen.  Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis , 1993, Nature.

[571]  K. Johnson.  An Update. , 1984, Journal of food protection.

[572]  E. Glaser.  The randomized clinical trial. , 1972, The New England journal of medicine.

[573]  J. Kershman.  GENESIS OF MICROGLIA IN THE HUMAN BRAIN , 1939 .

[574]  Edinburgh Research Explorer Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia , 2022 .