Monoketone analogs of curcumin, a new class of Fanconi anemia pathway inhibitors
暂无分享,去创建一个
Chao Yang | J. Snyder | S. Hiddingh | M. Turker | I. Landais | Matthew N. McCarroll | M. Hoatlin | Aiming Sun | Igor Landais
[1] A. Ashworth,et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. , 2009, The New England journal of medicine.
[2] J. Gautier,et al. PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. , 2009, DNA repair.
[3] R. Tuma. PARP inhibitors: will the new class of drugs match the hype? , 2009, Journal of the National Cancer Institute.
[4] J. Gautier,et al. Checkpoint signaling from a single DNA interstrand crosslink. , 2009, Molecular cell.
[5] Hans Joenje,et al. The genetic and molecular basis of Fanconi anemia. , 2009, Mutation research.
[6] I. Landais,et al. The Fanconi Anemia Protein FANCM Is Controlled by FANCD2 and the ATR/ATM Pathways* , 2009, The Journal of Biological Chemistry.
[7] Michael J. Emanuele,et al. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene , 2009, Cell.
[8] Sridhar Ramaswamy,et al. Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells , 2009, Cell.
[9] I. Landais,et al. A novel cell‐free screen identifies a potent inhibitor of the Fanconi anemia pathway , 2009, International journal of cancer.
[10] J. Gautier,et al. Fanconi anemia proteins stabilize replication forks. , 2008, DNA repair.
[11] S. Elledge,et al. FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway , 2008, Nature Structural &Molecular Biology.
[12] L. Lai,et al. Finding multiple target optimal intervention in disease-related molecular network , 2008, Molecular systems biology.
[13] M. Lavin,et al. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer , 2008, Nature Reviews Molecular Cell Biology.
[14] J. Snyder,et al. Inhibition of IκB Kinase-Nuclear Factor-κB Signaling Pathway by 3,5-Bis(2-flurobenzylidene)piperidin-4-one (EF24), a Novel Monoketone Analog of Curcumin , 2008, Molecular Pharmacology.
[15] J. Snyder,et al. EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1 , 2008, Cell cycle.
[16] Alan Ashworth,et al. A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[17] I. Gülçin,et al. Antioxidant and radical scavenging properties of curcumin. , 2008, Chemico-biological interactions.
[18] J. Snyder,et al. Radiosensitization of glioma cells with the curcumin analogs EF24 and EF31 , 2008 .
[19] Jean Gautier,et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. , 2008, Nature chemical biology.
[20] J. Snyder,et al. Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa , 2008 .
[21] R. Siebert,et al. Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[22] Weidong Wang. Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins , 2007, Nature Reviews Genetics.
[23] T. Taniguchi,et al. Proteasome function is required for DNA damage response and fanconi anemia pathway activation. , 2007, Cancer research.
[24] Akiko Shimamura,et al. Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. , 2007, The Journal of clinical investigation.
[25] N. Rahman,et al. Cancer genes associated with phenotypes in monoallelic and biallelic mutation carriers: new lessons from old players. , 2007, Human molecular genetics.
[26] M. Hoatlin,et al. DNA Structure-Induced Recruitment and Activation of the Fanconi Anemia Pathway Protein FANCD2 , 2007, Molecular and Cellular Biology.
[27] G. Peng,et al. DNA damage response: the players, the network and the role in tumor suppression. , 2007, Cancer Genomics & Proteomics.
[28] Michael J. Keiser,et al. Relating protein pharmacology by ligand chemistry , 2007, Nature Biotechnology.
[29] C. Brancolini,et al. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. , 2006, Cancer research.
[30] A. D’Andrea,et al. Phosphorylation of FANCD2 on Two Novel Sites Is Required for Mitomycin C Resistance , 2006, Molecular and Cellular Biology.
[31] J. Snyder,et al. Synthesis of EF24-tripeptide chloromethyl ketone: a novel curcumin-related anticancer drug delivery system. , 2006, Journal of medicinal chemistry.
[32] A. Gurtan,et al. The WD40 Repeats of FANCL Are Required for Fanconi Anemia Core Complex Assembly* , 2006, Journal of Biological Chemistry.
[33] A. D’Andrea,et al. Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway , 2006, Molecular Cancer Therapeutics.
[34] Weidong Wang,et al. Fanconi Anemia Proteins Are Required To Prevent Accumulation of Replication-Associated DNA Double-Strand Breaks , 2006, Molecular and Cellular Biology.
[35] Dean P. Jones,et al. EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism , 2005, Anti-cancer drugs.
[36] J. Snyder,et al. Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents. , 2004, Bioorganic & medicinal chemistry.
[37] N. Nukina,et al. Inhibition of Proteasomal Function by Curcumin Induces Apoptosis through Mitochondrial Pathway* , 2004, Journal of Biological Chemistry.
[38] W. Chan,et al. Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[39] James R. Burke,et al. BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice* , 2003, The Journal of Biological Chemistry.
[40] A. D’Andrea,et al. S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. , 2002, Blood.
[41] K. Cimprich,et al. A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. , 2002, Genes & development.
[42] G. Chintalwar,et al. Protective Activities of Some Phenolic 1,3‐Diketones against Lipid Peroxidation: Possible Involvement of the 1,3‐Diketone Moiety , 2002, Chembiochem : a European journal of chemical biology.
[43] T. Pandita,et al. Spontaneously immortalized cell lines obtained from adult Atm null mice retain sensitivity to ionizing radiation and exhibit a mutational pattern suggestive of oxidative stress , 2001, Oncogene.
[44] M. Bibikova,et al. Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. , 2001, Molecular cell.
[45] W. Brownell,et al. Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems. , 2000, Genes & development.
[46] S. Elledge,et al. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. , 2000, Genes & development.
[47] E. Wagner,et al. PARP is important for genomic stability but dispensable in apoptosis. , 1997, Genes & development.
[48] K. Chrzanowska,et al. Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair , 2010, Journal of Applied Genetics.
[49] J. Snyder,et al. Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa. , 2008, Journal of drug targeting.
[50] B. Aggarwal,et al. Curcumin: the Indian solid gold. , 2007, Advances in experimental medicine and biology.
[51] H. Hoehn,et al. Fanconi anemia: causes and consequences of genetic instability. , 2006, Genome dynamics.
[52] K. McIntyre,et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. , 2003, The Journal of biological chemistry.
[53] A. Manning,et al. Fanconi anemia protein complex is a novel target of the IKK signalsome , 2002, Journal of cellular biochemistry.
[54] M. Buchwald,et al. Identification of two complementation groups in Fanconi anemia , 1985, Somatic cell and molecular genetics.