论文信息 - Direct measurement of fluence rate in the human brain

Direct measurement of fluence rate in the human brain

Fluence rate was measured in normal and cancerous (glioma) human brain samples using a multichannel detector. Detector consisted of 8 isotrope fiber probes positioned around the central irradiating probe. Detecting probes were displaced one from other at a step 0.5 mm along the central irradiating fiber. Bare ends of detecting fibers were coupled with photodiode array. He-Ne (633 nm) or Nd:YAG (1064 nm) lasers were coupled with irradiating probe. Fluence rate was measured in each of 8 points in the depth range 5 mm. Measured mean penetration depths of 633 nm light were 0.70 mm, 0.50 mm and 0.40 mm for white matter, grey matter and glioma, respectively. For Nd:YAG laser, penetration depth was about 2.3 mm for normal tissue and glioma. Multichannel computerized detector allows to provide a small invasive real-time measurements of fluence rate in different tissues.

[1] Martin J. C. van Gemert,et al. Direction-dependent penetration of red light in white matter of the brain , 1994, Other Conferences.

[2] B. Wilson,et al. An update on the penetration depth of 630 nm light in normal and malignant human brain tissue in vivo. , 1986, Physics in medicine and biology.

[3] Igor Kravchenko,et al. Small isotrope probes for in vivo measurements of fluence rate , 1995, Other Conferences.

[4] Sergiy M. Dets,et al. Light propagation in tissues: effect of finite size of tissue sample , 1995, European Conference on Biomedical Optics.

[5] B. Wilson,et al. Instrumentation and light dosimetry for intra-operative photodynamic therapy (PDT) of malignant brain tumours. , 1986, Physics in medicine and biology.