27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells*
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Gaochao Zhou | S. Wright | J. Menke | E. Lund | Karen L. MacNaul | Erik G. Lund | John G. Menke | Samuel D. Wright | Carl P. Sparrow | Gaochao Zhou | X. Fu | K. Macnaul | C. Sparrow | Yuli Chen | Xuan Fu | Yuli Chen
[1] D. Epps,et al. Rapid separation of lipid classes in high yield and purity using bonded phase columns. , 1985, Journal of lipid research.
[2] R. Lawn,et al. ABC1 gene expression and ApoA-I-mediated cholesterol efflux are regulated by LXR. , 2000, Biochemical and biophysical research communications.
[3] A. Vaughan,et al. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. , 1999, The Journal of clinical investigation.
[4] S. Wright,et al. Tumor-promoting phorbol esters stimulate C3b and C3b' receptor-mediated phagocytosis in cultured human monocytes , 1982, The Journal of experimental medicine.
[5] A. Tall,et al. Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element. , 2000, The Journal of clinical investigation.
[6] I. Björkhem,et al. Cerebrotendinous xanthomatosis: a defect in mitochondrial 26-hydroxylation required for normal biosynthesis of cholic acid. , 1980, The Journal of clinical investigation.
[7] M. C. Hu,et al. Stimulation of macrophages and neutrophils by complexes of lipopolysaccharide and soluble CD14. , 1996, Journal of immunology.
[8] C. Sensen,et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency , 1999, Nature Genetics.
[9] Zhe Zhang,et al. Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. , 2001, Journal of lipid research.
[10] J. Sambrook,et al. Molecular Cloning: A Laboratory Manual , 2001 .
[11] A. Galloway,et al. Sterol 27-hydroxylase: high levels of activity in vascular endothelium. , 1994, Journal of lipid research.
[12] H. Jörnvall,et al. Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. , 1989, The Journal of biological chemistry.
[13] D. Mangelsdorf,et al. Nuclear receptor regulation of cholesterol and bile acid metabolism. , 1999, Current opinion in biotechnology.
[14] J. Nezu,et al. Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1 , 1997, FEBS letters.
[15] N. Maeda,et al. Markedly Reduced Bile Acid Synthesis but Maintained Levels of Cholesterol and Vitamin D Metabolites in Mice with Disrupted Sterol 27-Hydroxylase Gene* , 1998, The Journal of Biological Chemistry.
[16] D. Mangelsdorf,et al. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers. , 2000, Science.
[17] L. Moore,et al. Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha. , 2001, Journal of medicinal chemistry.
[18] M. Brown,et al. Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[19] T. Langmann,et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease , 1999, Nature Genetics.
[20] N. Javitt. Biologic role(s) of the 25(R),26-hydroxycholesterol metabolic pathway. , 2000, Biochimica et biophysica acta.
[21] U. Diczfalusy,et al. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. , 1995, Analytical biochemistry.
[22] H. Lindmark,et al. Oxysterols present in atherosclerotic tissue decrease the expression of lipoprotein lipase messenger RNA in human monocyte-derived macrophages. , 1996, The Journal of clinical investigation.
[23] O. Andersson,et al. Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans. , 1996, Arteriosclerosis, thrombosis, and vascular biology.
[24] K. Livak,et al. Real time quantitative PCR. , 1996, Genome research.
[25] D. Lütjohann,et al. Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. , 2001, Journal of lipid research.
[26] D. Russell,et al. Disruption of the Sterol 27-Hydroxylase Gene in Mice Results in Hepatomegaly and Hypertriglyceridemia , 2000, The Journal of Biological Chemistry.
[27] G. Schmitz,et al. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[28] D. Mangelsdorf,et al. Human White/Murine ABC8 mRNA Levels Are Highly Induced in Lipid-loaded Macrophages , 2000, The Journal of Biological Chemistry.
[29] D. Mangelsdorf,et al. An oxysterol signalling pathway mediated by the nuclear receptor LXRα , 1996, Nature.
[30] T. A. Spencer. The Squalene Dioxide Pathway of Steroid Biosynthesis , 1994 .
[31] G. Francis,et al. Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease. , 1995, The Journal of clinical investigation.
[32] U. Francke,et al. Mutations in the bile acid biosynthetic enzyme sterol 27-hydroxylase underlie cerebrotendinous xanthomatosis. , 1991, The Journal of biological chemistry.
[33] J. Piette,et al. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1 , 1999, Nature Genetics.
[34] I. Björkhem,et al. Elimination of Cholesterol in Macrophages and Endothelial Cells by the Sterol 27-Hydroxylase Mechanism , 1997, The Journal of Biological Chemistry.
[35] Jean-Marc A. Lobaccaro,et al. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ , 2000 .
[36] I. Björkhem,et al. Mechanism of degradation of the steroid side chain in the formation of bile acids. , 1992, Journal of lipid research.
[37] Hitoshi Shimano,et al. Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter , 2001, Molecular and Cellular Biology.
[38] T. Forte,et al. Abnormal high density lipoproteins in cerebrotendinous xanthomatosis. , 1981, The Journal of clinical investigation.
[39] Jasmine Chen,et al. The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[40] S. Skrede,et al. Demonstration of 26-hydroxylation of C27-steroids in human skin fibroblasts, and a deficiency of this activity in cerebrotendinous xanthomatosis. , 1986, The Journal of clinical investigation.
[41] J. Westman,et al. Sterol 27-hydroxylase- and apoAI/phospholipid-mediated efflux of cholesterol from cholesterol-laden macrophages: evidence for an inverse relation between the two mechanisms. , 1998, Arteriosclerosis, thrombosis, and vascular biology.
[42] H. Shimano,et al. Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene* , 2000, The Journal of Biological Chemistry.
[43] M. Osame,et al. Atherogenic risk factors in cerebrotendinous xanthomatosis. , 1991, Clinica chimica acta; international journal of clinical chemistry.
[44] S. Tsuji,et al. Mutations producing premature termination of translation and an amino acid substitution in the sterol 27-hydroxylase gene cause cerebrotendinous xanthomatosis associated with parkinsonism , 1999, Journal of neurology, neurosurgery, and psychiatry.
[45] P. Edwards,et al. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[46] M. Brown,et al. Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. , 1979, Proceedings of the National Academy of Sciences of the United States of America.
[47] R. Lathe,et al. Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease. , 1998, The Journal of clinical investigation.
[48] Edward,et al. Inhibitors of sterol synthesis. Chromatography of acetate derivatives of oxygenated sterols. , 1989, Journal of lipid research.
[49] T. Langmann,et al. Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages. , 1999, Biochemical and biophysical research communications.
[50] D. Russell,et al. Disruption of the Oxysterol 7α-Hydroxylase Gene in Mice* , 2000, The Journal of Biological Chemistry.
[51] S. Kliewer,et al. Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[52] A. Tall,et al. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. , 2000, The Journal of biological chemistry.
[53] R. Hammer,et al. Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα , 1998, Cell.
[54] M. Brown,et al. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. , 1976, Proceedings of the National Academy of Sciences of the United States of America.
[55] J. van der Linden,et al. Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin. , 1999, Journal of lipid research.
[56] V. Kostulas,et al. Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques. , 1997, Biochimica et biophysica acta.
[57] K.,et al. 24(S),25-Epoxycholesterol. Evidence consistent with a role in the regulation of hepatic cholesterogenesis. , 1985, The Journal of biological chemistry.
[58] Timothy M. Willson,et al. Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway* , 1997, The Journal of Biological Chemistry.