Effects of Polygonum cognatum Meissn. extract on indomethacin induced gastric damage in rats

We investigated the anti-ulcer activity of ethanol extracts of Polygonum cognatum on indomethacin induced gastric damage in rats. We evaluated the number of ulcer areas, oxidant and antioxidant parameters as well as histopathologic features in rat stomach. We measured the total antioxidant status of P. cognatum in concentrations from 1.56-100 mg/ml. P. cognatum extract inhibited indomethacin induced ulcer formation with an effect similar to a 20 mg/kg dose of the standard anti-ulcer drug, esomeprazole. All doses of P. cognatum extract exhibited positive effects on oxidative stress markers and histopathological features in the stomach tissue of rats. We suggest that the antioxidant activity of P. cognatum extract may be responsible for its gastroprotective effect and that P. cognatum extract may be a useful gastroprotective agent.

[1]  A. Harmankaya,et al.  The effects of dragon fruit (Hylocereus polyrhizus) extract on indomethacin-induced stomach ulcer in rats. , 2022, Journal of food biochemistry.

[2]  S. Yıldırım,et al.  Protective effect of chrysin on indomethacin induced gastric ulcer in rats: role of multi-pathway regulation , 2022, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

[3]  D. Bilici,et al.  Protective effect of luteolin on acute lung injury in a rat model of sepsis , 2020, Biotechnic & histochemistry : official publication of the Biological Stain Commission.

[4]  H. Un,et al.  The Protective Roles of Butein on Indomethacin Induced Gastric Ulcer in Mice. , 2020, The Eurasian journal of medicine.

[5]  Y. Bayir,et al.  Isolation of Major Compounds and Gastroprotective Activity of Alchemilla Caucasica on Indomethacin Induced Gastric Ulcers in Rats. , 2020, The Eurasian journal of medicine.

[6]  O. Sytar,et al.  In vivo bioactivity assessment on Epilobium species: A particular focus on Epilobium angustifolium and its components on enzymes connected with the healing process. , 2020, Journal of ethnopharmacology.

[7]  Y. Yeşil,et al.  Traditional knowledge of wild edible plants in Hasankeyf (Batman Province, Turkey) , 2019, Acta Societatis Botanicorum Poloniae.

[8]  N. Ibrahim,et al.  A comparative study on the possible protective effect of esomeprazole, spirulina, wheatgrass on indomethacin-induced gastric ulcer in male albino rats , 2019, Molecular Biology Reports.

[9]  E. Kozan,et al.  Effective eradication of pinworms (Syphacia obvelata and Aspiculuris tetraptera) with Polygonum cognatum Meissn. , 2019, Experimental parasitology.

[10]  R. Singh,et al.  Prodrugs of Non-steroidal Anti-inflammatory Drugs (NSAIDs): A Long March Towards Synthesis of Safer NSAIDs. , 2018, Mini reviews in medicinal chemistry.

[11]  S. S. Bilge,et al.  Effects of Nonsteroidal Anti-Inflammatory Drugs at the Molecular Level. , 2018, The Eurasian journal of medicine.

[12]  Vikas Kumar,et al.  Protective effect of oleane-12-en-3β-ol-28-oic acid 3β-D-glucopyranoside in ethanol induced gastric ulcer by enhancing the prostaglandin E2 level. , 2018, Journal of ethnopharmacology.

[13]  Y. Bayir,et al.  Aliskiren – a promising strategy for ovarian ischemia/reperfusion injury protection in rats via RAAS , 2016, Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.

[14]  Y. Bayir,et al.  The effect of alpha-lipoic acid in ovariectomy and inflammation-mediated osteoporosis on the skeletal status of rat bone. , 2013, European journal of pharmacology.

[15]  Y. Bayir,et al.  The effects of methanol extract of Lobaria pulmonaria, a lichen species, on indometacin‐induced gastric mucosal damage, oxidative stress and neutrophil infiltration , 2009, Phytotherapy research : PTR.

[16]  M. Tomczyk,et al.  Potentilla--a review of its phytochemical and pharmacological profile. , 2009, Journal of ethnopharmacology.

[17]  H. Wagner,et al.  Synergy research: approaching a new generation of phytopharmaceuticals. , 2009, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[18]  K. Kron,et al.  Phylogenetics of Polygonaceae with an Emphasis on the Evolution of Eriogonoideae , 2008 .

[19]  Y. Bayir,et al.  The inhibition of gastric mucosal lesion, oxidative stress and neutrophil-infiltration in rats by the lichen constituent diffractaic acid. , 2006, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[20]  M. Turan,et al.  Macro and Micro Mineral Content of Some Wild Edible Leaves Consumed in Eastern Anatolia , 2003 .

[21]  J. Moss,et al.  Herbal medicines and perioperative care. , 2001, Anesthesiology.

[22]  E. Yeşilada,et al.  Traditional medicine in Turkey. V. Folk medicine in the inner Taurus Mountains. , 1995, Journal of ethnopharmacology.

[23]  C. Cho,et al.  Stress-induced gastric ulceration: its aetiology and clinical implications. , 1992, Scandinavian journal of gastroenterology.

[24]  Y. Sun,et al.  A simple method for clinical assay of superoxide dismutase. , 1988, Clinical chemistry.

[25]  H. Satoh,et al.  Indomethacin produces gastric antral ulcers in the refed rat. , 1981, Gastroenterology.

[26]  K. Yagi,et al.  Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. , 1979, Analytical biochemistry.

[27]  A. Yildirim,et al.  Antioxidant and antimicrobial activities of Polygonum cognatum Meissn extracts , 2003 .

[28]  J. Sedlák,et al.  Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. , 1968, Analytical biochemistry.