Imaging findings in tuberous sclerosis with multiple retinal astrocytic hamartomas.

Figure 1. Fundus photograph (top) of the right eye shows retinal hamartomas superior and inferior to the optic disc in a patient with tuberous sclerosis. These hamartomas are glial tumors of the retinal nerve fiber layer that arise from retinal astrocytes and appear as yellowishgray, well-circumscribed, elevated nodular lesions.1 Retinal astrocytic hamartomas are most frequently associated with tuberous sclerosis,1 but may also be found rarely in patients with neurofibromatosis.2 Solitary, large, retinal astrocytomas can also occur in the absence of any systemic manifestations as an isolated presentation.3,4 Fluorescein angiography (bottom) shows staining of the lesions with hyperfluorescence in early phase and no leakage of dye in late phases of angiogram.