Hypospadias in sons of women exposed to ditheylstilbestrol: a true trans‐generational effect?

Figure 4—FISH metaphase from the fetal cord blood lymphocyte hybridized with the 10q telomeric probe (10qTEL) (spectrum red) and the 18p telomeric probe (18pTEL) (spectrum green) (Vysis, Downers Groove, IL, USA) shows one red 10qTEL signal on a normal chromosome 10, one red 10qTEL signal on the other normal chromosome 10, one red 10qTEL signal and one green 18pTEL signal on the derivative chromosome 18, or der(18), and one 18pTEL green signal on a normal chromosome 18. The labeled chromosomes 10, der(18), and 18 in the metaphase FISH picture are identified by DAPI-banded chromosomes using CytoVision workstation (Applied Imaging)

[1]  Chih-ping Chen,et al.  Prenatal diagnosis and molecular cytogenetic analysis of partial monosomy 10q (10q25.3→qter) and partial trisomy 18q (18q23→qter) in a fetus associated with cystic hygroma and ambiguous genitalia , 2005, Prenatal diagnosis.

[2]  C. Tzen,et al.  Hypospadias in sons of women exposed to diethylstilbestrol in utero , 2005, Prenatal diagnosis.

[3]  Chih-ping Chen,et al.  Recurrent fetal pyelectasis in a family with fetuses associated with partial trisomy 10q (10q24.1→qter) , 2005, Prenatal diagnosis.

[4]  Chih-ping Chen,et al.  Second‐trimester sonographic demonstration of retrognathia and bilateral pyelectasis in a fetus with a duplication of chromosome 10q24.1→qter , 2003, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[5]  C. Tzen,et al.  Prenatal diagnosis of de novo mosaic distal 18q deletion associated with congenital anomalies , 2003, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[6]  J. Verloop,et al.  Hypospadias in sons of women exposed to diethylstilbestrol in utero: a cohort study , 2002, The Lancet.

[7]  N. Hussain,et al.  Hypospadias and early gestation growth restriction in infants. , 2002, Pediatrics.

[8]  Chih-ping Chen,et al.  Prenatal diagnosis of a fetus with distal 10q trisomy , 1999, Prenatal diagnosis.

[9]  C. Yue,et al.  PRENATAL DIAGNOSIS OF A DELETION OF 18q IN A FETUS ASSOCIATED WITH MULTIPLE‐MARKER SCREEN POSITIVE RESULTS , 1997, Prenatal diagnosis.

[10]  E. Lieberman,et al.  A Comparison of Risk Factors for Preterm Labor and Term Small‐for‐Gestational‐Age Birth , 1996, Epidemiology.

[11]  S. Olson,et al.  Chorionic villus sampling: first-trimester prenatal diagnosis of partial 10q trisomy in a family with a 4/10 translocation. , 1985, American journal of obstetrics and gynecology.

[12]  M. Dachá,et al.  The possibility of prenatal diagnosis by gene dosage: Confirmation of duplication 10q24→qter from Got‐l activity in fetal erythrocytes , 1981, Prenatal diagnosis.

[13]  J. Yunis,et al.  A new syndrome resulting from partial trisomy for the distal third of the long arm of chromosome 10. , 1974, The Journal of pediatrics.

[14]  G. Lazjuk,et al.  Prenatal morphology of partial monosomy 18q. , 1987, Zentralblatt fur Gynakologie.

[15]  A. Schinzel,et al.  Catalogue of Unbalanced Chromosome Aberrations in Man , 1985 .