The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties

[1]  Ying Zhang,et al.  A438079 affects colorectal cancer cell proliferation, migration, apoptosis, and pyroptosis by inhibiting the P2X7 receptor. , 2021, Biochemical and biophysical research communications.

[2]  Elena De Marchi,et al.  P2X7 Variants in Oncogenesis , 2021, Cells.

[3]  Chih-Hsin Tang,et al.  IGFBP-3 stimulates human osteosarcoma cell migration by upregulating VCAM-1 expression. , 2020, Life sciences.

[4]  N. Jørgensen,et al.  Human P2X7 Receptor Causes Cycle Arrest in RPMI-8226 Myeloma Cells to Alter the Interaction with Osteoblasts and Osteoclasts , 2020, Cells.

[5]  K. Nakajima,et al.  Molecular profiling of bone remodeling occurring in musculoskeletal tumors , 2020, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[6]  F. Di Virgilio,et al.  Differential sensitivity of acute myeloid leukemia cells to daunorubicin depends on P2X7A versus P2X7B receptor expression , 2020, Cell Death & Disease.

[7]  S. Saccani,et al.  P2RX7B is a new theranostic marker for lung adenocarcinoma patients , 2020, Theranostics.

[8]  A. le Pape,et al.  P2X7 Receptor Promotes Mouse Mammary Cancer Cell Invasiveness and Tumour Progression, and Is a Target for Anticancer Treatment , 2020, Cancers.

[9]  F. Di Virgilio,et al.  P2X7 in Cancer: From Molecular Mechanisms to Therapeutics , 2020, Frontiers in Pharmacology.

[10]  D. Rassl,et al.  Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer , 2020, Oncogene.

[11]  L. Ricci-Vitiani,et al.  Upregulation of Epithelial-To-Mesenchymal Transition Markers and P2X7 Receptors Is Associated to Increased Invasiveness Caused by P2X7 Receptor Stimulation in Human Glioblastoma Stem Cells , 2019, Cells.

[12]  Kevin W. Eliceiri,et al.  ImageJ for the Next Generation of Scientific Image Data , 2019, Microscopy and Microanalysis.

[13]  Gang Cui,et al.  Hypoxia promotes osteosarcoma cell proliferation and migration through enhancing platelet-derived growth factor-BB/platelet-derived growth factor receptor-β axis. , 2019, Biochemical and biophysical research communications.

[14]  Yong Yang,et al.  Highly‐expressed P2X7 receptor promotes growth and metastasis of human HOS/MNNG osteosarcoma cells via PI3K/Akt/GSK3β/β‐catenin and mTOR/HIF1α/VEGF signaling , 2019, International journal of cancer.

[15]  F. Di Virgilio,et al.  The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment , 2019, Oncogene.

[16]  Z. Lei,et al.  Fibronectin‐1 modulated by the long noncoding RNA OIP5‐AS1/miR‐200b‐3p axis contributes to doxorubicin resistance of osteosarcoma cells , 2018, Journal of cellular physiology.

[17]  F. Di Virgilio,et al.  ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival , 2018, Oncogene.

[18]  N. Jørgensen,et al.  P2X7 receptor regulates osteoclast function and bone loss in a mouse model of osteoporosis , 2018, Scientific Reports.

[19]  D. Ferrari,et al.  A Purinergic Trail for Metastases. , 2017, Trends in pharmacological sciences.

[20]  Kevin W. Eliceiri,et al.  ImageJ2: ImageJ for the next generation of scientific image data , 2017, BMC Bioinformatics.

[21]  Peter Bankhead,et al.  QuPath: Open source software for digital pathology image analysis , 2017, Scientific Reports.

[22]  I. Novak,et al.  Targeting of the P2X7 receptor in pancreatic cancer and stellate cells , 2016, International journal of cancer.

[23]  Jeffrey T Leek,et al.  Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown , 2016, Nature Protocols.

[24]  F. Di Virgilio,et al.  Extracellular purines, purinergic receptors and tumor growth , 2016, Oncogene.

[25]  Lior Pachter,et al.  Near-optimal probabilistic RNA-seq quantification , 2016, Nature Biotechnology.

[26]  I. Novak,et al.  The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells , 2015, Molecular Cancer.

[27]  D. Heymann,et al.  Interleukin‐34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment , 2015, International journal of cancer.

[28]  Li Tang,et al.  P2X7 receptor stimulates breast cancer cell invasion and migration via the AKT pathway. , 2015, Oncology reports.

[29]  R. Linding,et al.  The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase , 2015, Nature.

[30]  Ankita Agrawal,et al.  P2X7 receptors: role in bone cell formation and function. , 2015, Journal of molecular endocrinology.

[31]  M. Ferracin,et al.  The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma , 2015, Oncogene.

[32]  Yan Liu,et al.  P2X7 Mediates ATP-Driven Invasiveness in Prostate Cancer Cells , 2014, PloS one.

[33]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[34]  F. Di Virgilio,et al.  Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma , 2014, PloS one.

[35]  D. Heymann,et al.  NVP-BEZ235, a dual PI3K/mTOR inhibitor, inhibits osteosarcoma cell proliferation and tumor development in vivo with an improved survival rate. , 2014, Cancer letters.

[36]  Bin Wang,et al.  Expression of lysyl oxidase in human osteosarcoma and its clinical significance: a tumor suppressive role of LOX in human osteosarcoma cells. , 2013, International journal of oncology.

[37]  Ankita Agrawal,et al.  Purinergic signalling in bone , 2012, Front. Endocrin..

[38]  I. Chessell,et al.  Genetic Background Strongly Influences the Bone Phenotype of P2X7 Receptor Knockout Mice , 2012, Journal of osteoporosis.

[39]  F. Di Virgilio,et al.  Expression of P2X7 receptor increases in vivo tumor growth. , 2012, Cancer research.

[40]  A. Fedenko,et al.  A Meta-Analysis of Osteosarcoma Outcomes in the Modern Medical Era , 2012, Sarcoma.

[41]  G. Reilly,et al.  Application of multiple forms of mechanical loading to human osteoblasts reveals increased ATP release in response to fluid flow in 3D cultures and differential regulation of immediate early genes , 2012, Journal of biomechanics.

[42]  D. Scherman,et al.  Formulated siRNAs targeting Rankl prevent osteolysis and enhance chemotherapeutic response in osteosarcoma models , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[43]  M. Cayuela,et al.  P2X7 receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness , 2011, Oncogene.

[44]  A. Llombart‐Bosch,et al.  Functional characterization of osteosarcoma cell lines provides representative models to study the human disease , 2011, Laboratory Investigation.

[45]  Peter F. M. Choong,et al.  The Molecular Pathogenesis of Osteosarcoma: A Review , 2011, Sarcoma.

[46]  L. Stokes,et al.  Significance of P2X7 receptor variants to human health and disease. , 2011, Recent patents on DNA & gene sequences.

[47]  I. Lewis,et al.  UK Guidelines for the Management of Bone Sarcomas , 2010, Sarcoma.

[48]  I. Jalilian,et al.  P2X7 receptor activation induces cell death and CD23 shedding in human RPMI 8226 multiple myeloma cells. , 2010, Biochimica et biophysica acta.

[49]  F. Di Virgilio,et al.  Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor , 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[50]  P. Insel,et al.  Basal Release of ATP: An Autocrine-Paracrine Mechanism for Cell Regulation , 2010, Science Signaling.

[51]  Petros Koumoutsakos,et al.  TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays. , 2009, BioTechniques.

[52]  F. Di Virgilio,et al.  Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase , 2008, PloS one.

[53]  Liqin Wang,et al.  A Truncated P2X7 Receptor Variant (P2X7-j) Endogenously Expressed in Cervical Cancer Cells Antagonizes the Full-length P2X7 Receptor through Hetero-oligomerization* , 2006, Journal of Biological Chemistry.

[54]  J. Wiley,et al.  Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor. , 2006, Blood.

[55]  S. Greenfeder,et al.  Identification and characterization of splice variants of the human P2X7 ATP channel. , 2005, Biochemical and biophysical research communications.

[56]  R. Duncan,et al.  Fluid Shear‐Induced ATP Secretion Mediates Prostaglandin Release in MC3T3‐E1 Osteoblasts , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[57]  S. M. Sims,et al.  Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. , 2003, Molecular endocrinology.

[58]  R. Hipskind,et al.  Expression of a P2X7 Receptor by a Subpopulation of Human Osteoblasts , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[59]  D. Maurici,et al.  Clinical relevance of Ki‐67 expression in bone tumors , 1995, Cancer.

[60]  W. Wood,et al.  Dominant maternal-effect mutations causing embryonic lethality in Caenorhabditis elegans. , 1990, Genetics.

[61]  J. Rhim,et al.  Characterization of human cells transformed in vitro by n‐methyl‐n'‐nitro‐n‐nitrosoguanidine , 1977, International journal of cancer.

[62]  C. Bradt,et al.  Cultivation in vitro of cells derived from a human osteosarcoma , 1971, Cancer.

[63]  F. Di Virgilio,et al.  Detection of Extracellular ATP in the Tumor Microenvironment, Using the pmeLUC Biosensor. , 2020, Methods in molecular biology.

[64]  Encyclopedia of Bone Biology , 2020 .

[65]  N. Jørgensen,et al.  Syddansk Universitet P 2 X 7 receptor regulates osteoclast function and bone loss in a mouse model of osteoporosis , 2018 .

[66]  Yousef Ahmed Fouad,et al.  Revisiting the hallmarks of cancer. , 2017, American journal of cancer research.

[67]  L. Stokes,et al.  Significance of P 2 X 7 Receptor Variants to Human Health and Disease , 2016 .

[68]  Ankita Agrawal,et al.  P 2 X 7 receptors : role in bone cell formation and function , 2015 .

[69]  C. Kennedy,et al.  Pharmacology of P2X receptors , 2012 .

[70]  B. Gu.  Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X 7 receptor , 2006 .

[71]  A. Montag,et al.  An Orthotopic Model of Human Osteosarcoma Growth and Spontaneous Pulmonary Metastasis , 2005, Clinical & Experimental Metastasis.

[72]  R. Hipskind,et al.  Multinucleated osteoclast formation in vivo and in vitro by P2X7 receptor-deficient mice. , 2003, Critical reviews in eukaryotic gene expression.

[73]  N. Tsuchida,et al.  In vitro differentiation of the human osteosarcoma cell lines, HOS and KHOS , 1992, Virchows Archiv. B, Cell pathology including molecular pathology.