Positive effects of polyethylene glycol conjugation to generation-4 polyamidoamine dendrimers employed as macromolecular MR contrast agents

Hisataka KOBAYASHI1, Satomi KAWAMOTO2, Tsuneo SAGA3, Noriko SATO3, Akira HIRAGA4, Takayoshi ISHIMORI3, Tabassum Laz HAQUE3, Junji KONISHI3, Kaori TOGASHI1, Martin W. BRECHBIEL5 1Kyoto University, Graduate School of Medicine, Department of Diagnostic and Interventional Imagiology, Kyoto, Japan; 2Otsu Municipal Hospital, Department of Radiology, Otsu, Shiga Japan; 3Kyoto University, Graduate school of Medicine, Department of Nuclear Medicine and Diagnostic Imaging, Kyoto, Kyoto Japan; 4Kyoto University Hospital, Department of Radiology, Kyoto, Kyoto Japan; 5NCI, NIH, Bldg. 10, Rm. B3B69, NIH,, Bethesda, MD USA;