Distribution and morphology of human cone photoreceptors stained with anti‐blue opsin

Primate cones maximally sensitive to short wavelength light (blue cones) have been previously identified by using indirect methods. We stained 7 wholemounted human retinas obtained from 6 female donors, using an affinity purified antibody to a 19 amino acid peptide sequence at the N‐terminus of blue opsin (Lerea et al., '89: Neuron 3:367–376), standard PAP immunocytochemistry, and controls. Cones were counted where all outer segments could be traced to inner segments and were measured where cells were well aligned vertically.

[1]  E. Willmer Colour of Small Objects , 1944, Nature.

[2]  W. D. Wright,et al.  Colour Sensitivity of the Fovea Centralis , 1945, Nature.

[3]  S. Karplus,et al.  ‘Foveal Tritanopia’ , 1947, Nature.

[4]  W. Stiles Increment thresholds and the mechanisms of colour vision. , 1949, Documenta ophthalmologica. Advances in ophthalmology.

[5]  G. Brindley,et al.  The summation areas of human colour‐receptive mechanisms at increment threshold , 1954, The Journal of physiology.

[6]  G. Wald THE RECEPTORS OF HUMAN COLOR VISION. , 1964, Science.

[7]  G Wald,et al.  Blue-blindness in the normal fovea. , 1967, Journal of the Optical Society of America.

[8]  D. G. Green The contrast sensitivity of the colour mechanisms of the human eye , 1968, The Journal of physiology.

[9]  L Frisén The cartographic deformations of the visual field. , 1970, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.

[10]  D. G. Green Visual acuity in the blue cone monochromat , 1972, The Journal of physiology.

[11]  E. Raviola,et al.  Gap junctions between photoreceptor cells in the vertebrate retina. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[12]  J M Enoch,et al.  Contrast sensitivity, Westheimer function and Stiles-Crawford effect in a blue cone monochromat. , 1973, Vision research.

[13]  G Wald,et al.  Color-Vision Mechanisms in the Peripheral Retinas of Normal and Dichromatic Observers , 1973, The Journal of general physiology.

[14]  F. Ederer,et al.  Shall we count numbers of eyes or numbers of subjects? , 1973, Archives of ophthalmology.

[15]  D. H. Kelly Spatio-temporal frequency characteristics of color-vision mechanisms* , 1974 .

[16]  N Drasdo,et al.  Non-linear projection of the retinal image in a wide-angle schematic eye. , 1974, The British journal of ophthalmology.

[17]  E. Raviola,et al.  Intramembrane organization of specialized contacts in the outer plexiform layer of the retina. A freeze-fracture study in monkeys and rabbits , 1975, The Journal of cell biology.

[18]  F. Hillenkamp,et al.  Laser microprobe mass analysis of organic materials , 1975, Nature.

[19]  C. Cavonius,et al.  Contrast sensitivity of individual colour mechanisms of human vision. , 1975, The Journal of physiology.

[20]  R. Marc,et al.  Chromatic organization of primate cones. , 1977, Science.

[21]  C. Stromeyer,et al.  Selective chromatic adaptation at different spatial frequencies , 1978, Vision Research.

[22]  H. Wässle,et al.  The mosaic of nerve cells in the mammalian retina , 1978, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[23]  J. Lythgoe,et al.  The visual pigments of rods and cones in the rhesus monkey, Macaca mulatta. , 1978, The Journal of physiology.

[24]  J. Mollon,et al.  Microspectrophotometric demonstration of four classes of photoreceptor in an old world primate, Macaca fascicularis. , 1980, The Journal of physiology.

[25]  R. Harwerth,et al.  Differential spectral photic damage to primate cones , 1980, Vision Research.

[26]  R. Winston The Visual Receptor as a Light Collector , 1981 .

[27]  David R. Williams,et al.  Punctate sensitivity of the blue-sensitive mechanism , 1981, Vision Research.

[28]  H. Sperling,et al.  Sensitivity of the blue-sensitive cones across the central retina , 1982, Vision Research.

[29]  J. Mollon,et al.  Human visual pigments: microspectrophotometric results from the eyes of seven persons , 1983, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[30]  Priv.-Doz. Dr. med. habil. Eberhart Zrenner Neurophysiological Aspects of Color Vision in Primates , 1983, Studies of Brain Function.

[31]  A. Mariani Bipolar cells in monkey retina selective for the cones likely to be blue-sensitive , 1984, Nature.

[32]  C. Stromeyer,et al.  Adaptive processes controlling sensitivity of short-wave cone pathways to different spatial frequencies , 1984, Vision Research.

[33]  S. Schein,et al.  Density profile of blue-sensitive cones along the horizontal meridian of macaque retina. , 1985, Investigative ophthalmology & visual science.

[34]  Regularity and Structure of the Spatial Pattern of Blue Cones of Macaque Retina: Comment , 1985 .

[35]  F. M. de Monasterio,et al.  Regularity and Structure of the Spatial Pattern of Blue Cones of Macaque Retina , 1985 .

[36]  Peter J. Diggle,et al.  Displaced amacrine cells in the retina of a rabbit: analysis of a bivariate spatial point pattern , 1986, Journal of Neuroscience Methods.

[37]  A. Hendrickson,et al.  A qualitative and quantitative analysis of the human fovea during development , 1986, Vision Research.

[38]  J. Nathans,et al.  Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. , 1986, Science.

[39]  Infrared holography with geletin films (A) , 1987 .

[40]  D. Baylor,et al.  Spectral sensitivity of human cone photoreceptors , 1987, Nature.

[41]  P K Ahnelt,et al.  Identification of a subtype of cone photoreceptor, likely to be blue sensitive, in the human retina , 1987, The Journal of comparative neurology.

[42]  Christine A. Curcio Diameters of presumed cone apertures in human retina (A) , 1987 .

[43]  D. Williams,et al.  Cone spacing and the visual resolution limit. , 1987, Journal of the Optical Society of America. A, Optics and image science.

[44]  A. Eisner,et al.  Sensitivities in older eyes with good acuity: cross-sectional norms. , 1987, Investigative ophthalmology & visual science.

[45]  W. H. Miller,et al.  Does cone positional disorder limit resolution? , 1987, Journal of the Optical Society of America. A, Optics and image science.

[46]  A. Hendrickson,et al.  Distribution of cones in human and monkey retina: individual variability and radial asymmetry. , 1987, Science.

[47]  J. M. Hopkins,et al.  Cone connections of the horizontal cells of the rhesus monkey’s retina , 1987, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[48]  Á. Szél,et al.  Identification of the blue‐sensitive cones in the mammalian retina by anti‐visual pigment antibody , 1988, The Journal of comparative neurology.

[49]  J. Werner,et al.  Sensitivity of human foveal color mechanisms throughout the life span. , 1988, Journal of the Optical Society of America. A, Optics and image science.

[50]  C. Johnson,et al.  Age-related changes in the central visual field for short-wavelength-sensitive pathways. , 1988, Journal of the Optical Society of America. A, Optics and image science.

[51]  G. Haegerstrom‐Portnoy,et al.  Short-wavelength-sensitive-cone sensitivity loss with aging: a protective role for macular pigment? , 1988, Journal of the Optical Society of America. A, Optics and image science.

[52]  Kenneth R. Sloan,et al.  Computer methods for sampling, reconstruction, display and analysis of retinal whole mounts , 1989, Vision Research.

[53]  V. Perry Dendritic Interactions between Cell Populations in the Developing Retina , 1989 .

[54]  Christine A. Curcio,et al.  The spatial resolution capacity of human foveal retina , 1989, Vision Research.

[55]  A. Hendrickson,et al.  Photoreceptor topography of the retina in the adult pigtail macaque (Macaca nemestrina) , 1989, The Journal of comparative neurology.

[56]  K. Mullen,et al.  Human photopic vision with only short wavelength cones: post‐receptoral properties. , 1989, The Journal of physiology.

[57]  L. Peichl,et al.  Topography of cones and rods in the tree shrew retina , 1989, The Journal of comparative neurology.

[58]  C. Lerea,et al.  α transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina , 1989, Neuron.

[59]  J. Del Valle,et al.  Localization of immunoreactive cholecystokinin precursor to amacrine cells and bipolar cells of the macaque monkey retina , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[60]  Robert W. Williams,et al.  Photoreceptor mosaic: Number and distribution of rods and cones in the rhesus monkey retina , 1990, The Journal of comparative neurology.

[61]  P K Ahnelt,et al.  Iso-orientation areas in the foveal cone mosaic , 1990, Visual Neuroscience.

[62]  T Ohtsuka,et al.  Telodendrial contact of HRP‐filled photoreceptors in the turtle retina: Pathways of photoreceptor coupling , 1990, The Journal of comparative neurology.

[63]  C A Curcio,et al.  Developmental redistribution of photoreceptors across the Macaca nemestrina (pigtail macaque) retina , 1990, The Journal of comparative neurology.

[64]  P. Rakić,et al.  Distribution of photoreceptor subtypes in the retina of diurnal and nocturnal primates , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[65]  J. Hurley,et al.  A phosphodiesterase inhibitor specific to a subset of bovine retinal cones. , 1990, The Journal of biological chemistry.

[66]  D. Baylor,et al.  Visual transduction in cones of the monkey Macaca fascicularis. , 1990, The Journal of physiology.

[67]  S. Jacobson,et al.  Photoreceptor rosettes with blue cone opsin immunoreactivity in retinitis pigmentosa. , 1990, Ophthalmology.

[68]  H. Kolb,et al.  Identification of pedicles of putative blue‐sensitive cones in the human retina , 1990, The Journal of comparative neurology.

[69]  A. Hendrickson,et al.  Human photoreceptor topography , 1990, The Journal of comparative neurology.

[70]  Christine A. Curcio,et al.  Chapter 5 Organization and development of the primate photoreceptor mosaic , 1991 .

[71]  Peter Sterling,et al.  Gap junctions between the pedicles of macaque foveal cones , 1992, Vision Research.