Intramuscular and intratendinous placenta‐derived mesenchymal stromal‐like cell treatment of a chronic quadriceps tendon rupture

Quadriceps tendon ruptures (QTRs) are rare but debilitating injuries, often associated with chronic metabolic conditions or long‐term steroid treatment. While the surgical treatment for acute QTRs is described thoroughly, no common strategy exists for the often frustrating treatment of chronic, reoccurring QTRs. The pro‐angiogenic and immunomodulatory properties of placenta‐derived adherent mesenchymal stromal‐like (PLX‐PAD) cells have been described to protect musculoskeletal tissues from inflammation and catabolic cytokine migration, yet little is known about the regenerative potential of PLX‐PAD cells in repetitively damaged tendon tissue.

[1]  S. Hajdu,et al.  Gait analysis and body composition after treatment of quadriceps tendon ruptures showed equal results independent of suture anchor or transosseus repair technique used: a pilot study , 2020, Disability and rehabilitation.

[2]  H. Bansal,et al.  Management of chronic quadriceps rupture with novel "chariot suture technique": A case report and review. , 2020, Journal of clinical orthopaedics and trauma.

[3]  K. Sugg,et al.  Adaptive and Innate Immune Cell Responses in Tendons and Lymph Nodes After Tendon Injury and Repair. , 2020, Journal of applied physiology.

[4]  O. Parolini,et al.  Mesenchymal Stromal Cells from Fetal and Maternal Placenta Possess Key Similarities and Differences: Potential Implications for Their Applications in Regenerative Medicine , 2020, Cells.

[5]  V. Denaro,et al.  Metallic versus biodegradable suture anchors for rotator cuff repair: a case control study , 2019, BMC Musculoskeletal Disorders.

[6]  J. M. Guimarães,et al.  Surgical Treatment of Chronic Rupture of the Quadriceps Using a Modified Pulvertaft Weave Technique , 2019, Arthroscopy techniques.

[7]  S. Rodeo,et al.  Use of Human Placenta-Derived Cells in a Preclinical Model of Tendon Injury. , 2019, The Journal of bone and joint surgery. American volume.

[8]  Manesh R. Patel,et al.  PLX-PAD Cell Treatment of Critical Limb Ischaemia: Rationale and Design of the PACE Trial. , 2019, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[9]  F. Bassetto,et al.  Comparison of reasorbeable mini anchor versus non reasorbeable: histological evaluation in an experimental rabbit model. , 2019, Muscles, ligaments and tendons journal.

[10]  C. Meisel,et al.  Immunomodulatory placental‐expanded, mesenchymal stromal cells improve muscle function following hip arthroplasty , 2018, Journal of cachexia, sarcopenia and muscle.

[11]  S. Hajdu,et al.  Clinical outcomes after treatment of quadriceps tendon ruptures show equal results independent of suture anchor or transosseus repair technique used – A pilot study , 2018, PloS one.

[12]  Noa Sher,et al.  Placenta-derived PLX-PAD mesenchymal-like stromal cells are efficacious in rescuing blood flow in hind limb ischemia mouse model by a dose- and site-dependent mechanism of action. , 2017, Cytotherapy.

[13]  R. LaPrade,et al.  Open Repair of Quadriceps Tendon With Suture Anchors and Semitendinosus Tendon Allograft Augmentation , 2017, Arthroscopy techniques.

[14]  Jason T Maikos,et al.  Poster 88 Gait Analysis after Bilateral Quadriceps Tendon Rupture in a Patient Who Elected to be Conservatively Managed: A Case Report , 2016, PM & R : the journal of injury, function, and rehabilitation.

[15]  J. Seon,et al.  Surgical Treatment of Neglected Traumatic Quadriceps Tendon Rupture with Knee Ankylosis , 2016, Knee surgery & related research.

[16]  H. Rehman,et al.  Quadriceps tendon repair using hamstring, prolene mesh and autologous conditioned plasma augmentation. A novel technique for repair of chronic quadriceps tendon rupture. , 2015, The Knee.

[17]  P. Lazarovici,et al.  Human placental eXpanded (PLX) mesenchymal-like adherent stromal cells confer neuroprotection to nerve growth factor (NGF)-differentiated PC12 cells exposed to ischemia by secretion of IL-6 and VEGF. , 2015, Biochimica et biophysica acta.

[18]  Matthew J. Silva,et al.  The early inflammatory response after flexor tendon healing: A gene expression and histological analysis , 2014, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[19]  A. Chajut,et al.  Cardioprotection by placenta-derived stromal cells in a murine myocardial infarction model. , 2013, The Journal of surgical research.

[20]  G. Schulze-Tanzil,et al.  The role of pro‐inflammatory and immunoregulatory cytokines in tendon healing and rupture: new insights , 2011, Scandinavian journal of medicine & science in sports.

[21]  A. Grasso,et al.  Comparison between metal and biodegradable suture anchors in the arthroscopic treatment of traumatic anterior shoulder instability: a prospective randomized study , 2010, Knee Surgery, Sports Traumatology, Arthroscopy.

[22]  Amir Toren,et al.  The role of placental-derived adherent stromal cell (PLX-PAD) in the treatment of critical limb ischemia. , 2009, Cytotherapy.

[23]  C. Court-Brown,et al.  The epidemiology of musculoskeletal tendinous and ligamentous injuries. , 2008, Injury.

[24]  C. Tai,et al.  A Modified Method for Reconstruction of Chronic Rupture of the Quadriceps Tendon after Total Knee Replacement , 2008 .

[25]  H. Redmond,et al.  Cell response to surgery. , 2006, Archives of surgery.

[26]  M. Heinzelmann,et al.  Quadriceps and patellar tendon rupture. , 2006, Injury.

[27]  N. Maffulli,et al.  Reconstruction of a chronic quadriceps tendon tear in a body builder , 2006, Knee Surgery, Sports Traumatology, Arthroscopy.

[28]  N. Tejwani,et al.  Quadriceps Tendon Rupture , 2003, The Journal of the American Academy of Orthopaedic Surgeons.

[29]  S. Calvano,et al.  Inflammatory cytokines and cell response in surgery. , 2000, Surgery.

[30]  M. Wahby,et al.  The effect of anaesthesia and surgery on plasma cytokine production , 1999, Anaesthesia.

[31]  M. Zanetti,et al.  [Ultrasonography and magnetic resonance tomography (MRI) of tendon injuries]. , 1995, Der Orthopade.

[32]  P. Kannus,et al.  Histopathological changes preceding spontaneous rupture of a tendon. A controlled study of 891 patients. , 1991, The Journal of bone and joint surgery. American volume.

[33]  J. Moreta,et al.  Chronic Quadriceps Tendon Rupture After Total Knee Arthroplasty Augmented With Synthetic Mesh. , 2017, Orthopedics.

[34]  A. Hanssen,et al.  Synthetic Mesh Augmentation of Acute and Subacute Quadriceps Tendon Repair. , 2016, Orthopedics.

[35]  C. J. McGrath,et al.  Effect of exchange rate return on volatility spill-over across trading regions , 2012 .