Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet.

[1]  E. Elinav,et al.  Circadian Coordination of Antimicrobial Responses. , 2017, Cell host & microbe.

[2]  P. Puchalska,et al.  Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. , 2017, Cell metabolism.

[3]  J. H. Cross,et al.  Ketogenic diet guidelines for infants with refractory epilepsy. , 2016, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

[4]  Pierre Baldi,et al.  Gut microbiota directs PPARγ‐driven reprogramming of the liver circadian clock by nutritional challenge , 2016, EMBO reports.

[5]  Babak Shahbaba,et al.  What time is it? Deep learning approaches for circadian rhythms , 2016, Bioinformatics.

[6]  N. Simone,et al.  Obesity and tumor growth: inflammation, immunity, and the role of a ketogenic diet , 2016, Current opinion in clinical nutrition and metabolic care.

[7]  Sama F. Sleiman,et al.  Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body β-hydroxybutyrate , 2016, eLife.

[8]  Hongyu Zhao,et al.  Metabolic Regulation of Gene Expression by Histone Lysine β‐hydroxybutyrylation , 2016, Molecular cell.

[9]  J. Ripperger,et al.  Liver-derived ketone bodies are necessary for food anticipation , 2016, Nature Communications.

[10]  O. Froy,et al.  Ketogenic diet delays the phase of circadian rhythms and does not affect AMP-activated protein kinase (AMPK) in mouse liver , 2015, Molecular and Cellular Endocrinology.

[11]  L. Cantley,et al.  Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. , 2015, Biochimica et biophysica acta.

[12]  Pierre Baldi,et al.  The pervasiveness and plasticity of circadian oscillations: the coupled circadian-oscillators framework , 2015, Bioinform..

[13]  D. Karall,et al.  Ketogenic diets in patients with inherited metabolic disorders , 2015, Journal of Inherited Metabolic Disease.

[14]  Alan L. Hutchison,et al.  Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. , 2015, Cell host & microbe.

[15]  Paolo Sassone-Corsi,et al.  Time for Food: The Intimate Interplay between Nutrition, Metabolism, and the Circadian Clock , 2015, Cell.

[16]  A. Paoli,et al.  Ketosis, ketogenic diet and food intake control: a complex relationship , 2015, Front. Psychol..

[17]  J. Hawley,et al.  Integrative Biology of Exercise , 2014, Cell.

[18]  M. Lazar,et al.  Nuclear receptor Rev-erbα: up, down, and all around , 2014, Trends in Endocrinology & Metabolism.

[19]  R. Veech Ketone ester effects on metabolism and transcription , 2014, Journal of Lipid Research.

[20]  T. Vanitallie,et al.  Ketone body therapy: from the ketogenic diet to the oral administration of ketone ester , 2014, Journal of Lipid Research.

[21]  J. Buatti,et al.  Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism , 2014, Redox biology.

[22]  Pierre Baldi,et al.  Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism , 2014, Cell.

[23]  A. Paoli,et al.  Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets , 2014, European Journal of Clinical Nutrition.

[24]  B. Grygiel-Górniak Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications – a review , 2014, Nutrition Journal.

[25]  J. Takahashi,et al.  Molecular architecture of the mammalian circadian clock. , 2014, Trends in cell biology.

[26]  E. Verdin,et al.  Ketone bodies as signaling metabolites , 2014, Trends in Endocrinology & Metabolism.

[27]  Pierre Baldi,et al.  Reprogramming of the Circadian Clock by Nutritional Challenge , 2013, Cell.

[28]  Matthew J. Rardin,et al.  SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. , 2013, Cell metabolism.

[29]  A. Keshavarzian,et al.  Disruption of the Circadian Clock in Mice Increases Intestinal Permeability and Promotes Alcohol-Induced Hepatic Pathology and Inflammation , 2013, PloS one.

[30]  Pierre Baldi,et al.  Circadian clock regulates the host response to Salmonella , 2013, Proceedings of the National Academy of Sciences.

[31]  C. Mobbs,et al.  Treatment of Diabetes and Diabetic Complications With a Ketogenic Diet , 2013, Journal of child neurology.

[32]  P. Chambon,et al.  Homeostasis in Intestinal Epithelium Is Orchestrated by the Circadian Clock and Microbiota Cues Transduced by TLRs , 2013, Cell.

[33]  Bárbara Martínez-Pastor,et al.  A tale of metabolites: the cross-talk between chromatin and energy metabolism. , 2013, Cancer discovery.

[34]  Eric Verdin,et al.  Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor , 2013, Science.

[35]  P. Sassone-Corsi,et al.  Metabolism and the circadian clock converge. , 2013, Physiological reviews.

[36]  J. Takahashi,et al.  Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals , 2012, Science.

[37]  Pierre Baldi,et al.  CircadiOmics: integrating circadian genomics, transcriptomics, proteomics and metabolomics , 2012, Nature Methods.

[38]  J. Takahashi,et al.  Central and peripheral circadian clocks in mammals. , 2012, Annual review of neuroscience.

[39]  Satchidananda Panda,et al.  Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. , 2012, Cell metabolism.

[40]  Pierre Baldi,et al.  Cyber-T web server: differential analysis of high-throughput data , 2012, Nucleic Acids Res..

[41]  A. Hartman,et al.  Ketone bodies in epilepsy , 2012, Journal of neurochemistry.

[42]  Pierre Baldi,et al.  Coordination of the transcriptome and metabolome by the circadian clock , 2012, Proceedings of the National Academy of Sciences.

[43]  Paolo Sassone-Corsi,et al.  Connecting Threads: Epigenetics and Metabolism , 2012, Cell.

[44]  Xiaohui Xie,et al.  MotifMap: integrative genome-wide maps of regulatory motif sites for model species , 2011, BMC Bioinformatics.

[45]  D. Blum,et al.  D-β-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease , 2011, PloS one.

[46]  Felix Naef,et al.  Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver , 2011, PLoS biology.

[47]  Joseph S. Takahashi,et al.  Circadian Integration of Metabolism and Energetics , 2010, Science.

[48]  F. Alt,et al.  SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. , 2010, Cell metabolism.

[49]  Karl Kornacker,et al.  JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets , 2010, Journal of biological rhythms.

[50]  Michael Müller,et al.  Peroxisome Proliferator-Activated Receptor Alpha Target Genes , 2010, PPAR research.

[51]  S. Panda,et al.  Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression , 2009, Proceedings of the National Academy of Sciences.

[52]  K. Kadota,et al.  Ketogenic Diet Disrupts the Circadian Clock and Increases Hypofibrinolytic Risk by Inducing Expression of Plasminogen Activator Inhibitor-1 , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[53]  P. Sassone-Corsi,et al.  Circadian Control of the NAD+ Salvage Pathway by CLOCK-SIRT1 , 2009, Science.

[54]  J. Takahashi,et al.  Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis , 2009, Science.

[55]  Xiaohui Xie,et al.  MotifMap: a human genome-wide map of candidate regulatory motif sites , 2009, Bioinform..

[56]  Paolo Sassone-Corsi,et al.  The NAD+-Dependent Deacetylase SIRT1 Modulates CLOCK-Mediated Chromatin Remodeling and Circadian Control , 2008, Cell.

[57]  Florian Kreppel,et al.  SIRT1 Regulates Circadian Clock Gene Expression through PER2 Deacetylation , 2008, Cell.

[58]  Brad T. Sherman,et al.  Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.

[59]  Kathryn Moynihan Ramsey,et al.  High-fat diet disrupts behavioral and molecular circadian rhythms in mice. , 2007, Cell metabolism.

[60]  J. Flier,et al.  Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. , 2007, Cell metabolism.

[61]  H. Otu,et al.  A high-fat, ketogenic diet induces a unique metabolic state in mice. , 2007, American journal of physiology. Endocrinology and metabolism.

[62]  F. Tamanini,et al.  Structure function analysis of mammalian cryptochromes. , 2007, Cold Spring Harbor symposia on quantitative biology.

[63]  Jason P. DeBruyne,et al.  A Clock Shock: Mouse CLOCK Is Not Required for Circadian Oscillator Function , 2006, Neuron.

[64]  Ueli Schibler,et al.  Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions , 2006, Nature Genetics.

[65]  H. Okamura Clock Genes in Cell Clocks: Roles, Actions, and Mysteries , 2004, Journal of biological rhythms.

[66]  G. Mitchell,et al.  Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry. , 2004, Prostaglandins, leukotrienes, and essential fatty acids.

[67]  Paolo Sassone-Corsi,et al.  A Web of Circadian Pacemakers , 2002, Cell.

[68]  Pierre Baldi,et al.  A Bayesian framework for the analysis of microarray expression data: regularized t -test and statistical inferences of gene changes , 2001, Bioinform..

[69]  Y Sakaki,et al.  Entrainment of the circadian clock in the liver by feeding. , 2001, Science.

[70]  D. Gilbert,et al.  The Ketogenic Diet: Seizure Control Correlates Better With Serum β-Hydroxybutyrate Than With Urine Ketones , 2000, Journal of child neurology.

[71]  K. Clarke,et al.  D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[72]  D. Kelly,et al.  A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[73]  W. Wahli,et al.  Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting , 1999 .

[74]  W. Wahli,et al.  Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. , 1999, The Journal of clinical investigation.