Quantifying the Contributions of Training Data and Algorithm Logic to the Performance of Automated Cause-assignment Algorithms for Verbal Autopsy.

A verbal autopsy (VA) consists of a survey with a relative or close contact of a person who has recently died. VA surveys are commonly used to infer likely causes of death for individuals when deaths happen outside of hospitals or healthcare facilities. Several statistical and algorithmic methods are available to assign cause of death using VA surveys. Each of these methods require as inputs some information about the joint distribution of symptoms and causes. In this note, we examine the generalizability of this symptom-cause information by comparing different automated coding methods using various combinations of inputs and evaluation data. VA algorithm performance is affected by both the specific SCI themselves and the logic of a given algorithm. Using a variety of performance metrics for all existing VA algorithms, we demonstrate that in general the adequacy of the information about the joint distribution between symptoms and cause affects performance at least as much or more than algorithm logic.