Regulated and constitutive activation of specific signalling pathways by the human S1P5 receptor

[1]  Darrell R. Abernethy,et al.  International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels , 2003, Pharmacological Reviews.

[2]  Kevin R. Lynch,et al.  International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature , 2002, Pharmacological Reviews.

[3]  M. Lohse,et al.  Internalization Determinants of the Parathyroid Hormone Receptor Differentially Regulate β-Arrestin/Receptor Association* , 2002, The Journal of Biological Chemistry.

[4]  P. Corvol,et al.  Constitutive Internalization of Constitutively Active Angiotensin II AT1A Receptor Mutants Is Blocked by Inverse Agonists* , 2002, The Journal of Biological Chemistry.

[5]  K. Nozaki,et al.  Molecular mechanism for endothelin-1-induced stress-fiber formation: analysis of G proteins using a mutant endothelin(A) receptor. , 2002, Molecular pharmacology.

[6]  R. Graham,et al.  Phe(303) in TMVI of the alpha(1B)-adrenergic receptor is a key residue coupling TM helical movements to G-protein activation. , 2002, Biochemistry.

[7]  A. Scheer,et al.  Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling. , 2001, The Journal of biological chemistry.

[8]  E. Meng,et al.  Receptor activation: what does the rhodopsin structure tell us? , 2001, Trends in pharmacological sciences.

[9]  D. Im,et al.  Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. , 2001, Biochemistry.

[10]  H. Sarau,et al.  EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. , 2001, Journal of molecular and cellular cardiology.

[11]  J. Gutkind,et al.  G-protein-coupled receptors and signaling networks: emerging paradigms. , 2001, Trends in pharmacological sciences.

[12]  D. Leopoldt,et al.  Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS). , 2001, Experimental cell research.

[13]  S. Rees,et al.  Detection of receptor ligands by monitoring selective stabilization of a Renilla luciferase‐tagged, constitutively active mutant, G‐protein‐coupled receptor , 2001, British journal of pharmacology.

[14]  Sylvia Wong,et al.  Nrg-1 Belongs to the Endothelial Differentiation Gene Family of G Protein-coupled Sphingosine-1-phosphate Receptors* , 2001, The Journal of Biological Chemistry.

[15]  M. Brann,et al.  Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor. , 2000, The Journal of biological chemistry.

[16]  M. Cross,et al.  G Protein-Coupled Receptor-Mediated Mitogen-Activated Protein Kinase Activation through Cooperation of Gαq and Gαi Signals , 2000, Molecular and Cellular Biology.

[17]  S. Rees,et al.  Resolution of inverse agonist-induced up-regulation from constitutive activity of mutants of the alpha(1b)-adrenoceptor. , 2000, Molecular pharmacology.

[18]  J. Sjöstrand,et al.  Caspase and proteasome activity during staurosporin-induced apoptosis in lens epithelial cells. , 2000, Investigative ophthalmology & visual science.

[19]  G. Kroemer,et al.  Caspase-independent commitment phase to apoptosis in activated blood T lymphocytes: reversibility at low apoptotic insult. , 2000, Blood.

[20]  S. Milstien,et al.  Sphingosine‐1‐phosphate: signaling inside and out , 2000, FEBS letters.

[21]  M. Piascik,et al.  Regulation of the cellular localization and signaling properties of the alpha(1B)- and alpha(1D)-adrenoceptors by agonists and inverse agonists. , 2000, Molecular pharmacology.

[22]  A. Scheer,et al.  Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation. , 2000, Molecular pharmacology.

[23]  W. Moolenaar Bioactive lysophospholipids and their G protein-coupled receptors. , 1999, Experimental cell research.

[24]  K. Claffey,et al.  Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate , 1999, Cell.

[25]  G. Almazan,et al.  Localization of Functional Prostaglandin E2 Receptors EP3 and EP4 in the Nuclear Envelope* , 1999, The Journal of Biological Chemistry.

[26]  S. Rhee,et al.  Inositides in the nucleus: presence and characterisation of the isozymes of phospholipase beta family in NIH 3T3 cells. , 1999, Biochimica et Biophysica Acta.

[27]  J. Bockaert,et al.  Molecular tinkering of G protein‐coupled receptors: an evolutionary success , 1999, The EMBO journal.

[28]  M. Ishida,et al.  Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src. , 1999, The Journal of clinical investigation.

[29]  S. Spiegel,et al.  Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218* , 1999, The Journal of Biological Chemistry.

[30]  E. Brown,et al.  Physiology and pathophysiology of the extracellular calcium-sensing receptor. , 1999, The American journal of medicine.

[31]  L. Bohn,et al.  Requirement of Receptor Internalization for Opioid Stimulation of Mitogen-Activated Protein Kinase: Biochemical and Immunofluorescence Confocal Microscopic Evidence , 1999, The Journal of Neuroscience.

[32]  R. Leurs,et al.  Agonist-independent regulation of constitutively active G-protein-coupled receptors. , 1998, Trends in biochemical sciences.

[33]  Y. Ono,et al.  Proteolytic activation of PKN by caspase-3 or related protease during apoptosis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[34]  H. Bourne,et al.  G-protein diseases furnish a model for the turn-on switch , 1998, Nature.

[35]  C. H. Liu,et al.  Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. , 1998, Science.

[36]  K. Kawamura,et al.  Intracellular distribution of adenylate cyclase in human cardiocytes determined by electron microscopic cytochemistry , 1998, Microscopy research and technique.

[37]  Jason C. Mills,et al.  Apoptotic Membrane Blebbing Is Regulated by Myosin Light Chain Phosphorylation , 1998, The Journal of cell biology.

[38]  A. Malviya,et al.  “Tell Me Where Is Calcium Bred”: Clarifying the Roles of Nuclear Calcium , 1998, Cell.

[39]  M. Caron,et al.  Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase* , 1998, The Journal of Biological Chemistry.

[40]  J. Wess,et al.  Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer. Molecular basis and clinical implication. , 1997, The Journal of clinical investigation.

[41]  N. Thornberry,et al.  Caspases: killer proteases. , 1997, Trends in biochemical sciences.

[42]  Y. Igarashi,et al.  Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. , 1997, Journal of biochemistry.

[43]  J. Baldassare,et al.  Nuclear Translocation of RhoA Mediates the Mitogen-induced Activation of Phospholipase D Involved in Nuclear Envelope Signal Transduction* , 1997, The Journal of Biological Chemistry.

[44]  J. Weiner,et al.  Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex , 1996, The Journal of cell biology.

[45]  T. Kenakin The classification of seven transmembrane receptors in recombinant expression systems. , 1996, Pharmacological reviews.

[46]  T. Kenakin,et al.  The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy. , 1996, Journal of theoretical biology.

[47]  S. Swillens,et al.  In Chinese hamster ovary K1 cells dog and human thyrotropin receptors activate both the cyclic AMP and the phosphatidylinositol 4,5-bisphosphate cascades in the presence of thyrotropin and the cyclic AMP cascade in its absence. , 1995, European journal of biochemistry.

[48]  S. Coughlin Expanding horizons for receptors coupled to G proteins: diversity and disease. , 1994, Current opinion in cell biology.

[49]  R. Lefkowitz,et al.  A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[50]  D. Oprian,et al.  Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness , 1994, Nature.

[51]  P. Insel,et al.  Immunoelectron microscopic identification of cytoplasmic and nuclear Gsα in S49 lymphoma cells , 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[52]  J. Parma,et al.  Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas , 1993, Nature.

[53]  T. Minegishi,et al.  A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty , 1993, Nature.

[54]  H. D. Cavanagh,et al.  Nuclear muscarinic acetylcholine receptors in corneal cells from rabbit. , 1993, Investigative ophthalmology & visual science.

[55]  R. Lefkowitz,et al.  Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. , 1993, Trends in pharmacological sciences.

[56]  R. Lefkowitz,et al.  A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. , 1993, The Journal of biological chemistry.

[57]  H. Singer,et al.  Angiotensin-II-binding sites on hepatocyte nuclei. , 1992, Endocrinology.

[58]  M. Caron,et al.  beta-Arrestin: a protein that regulates beta-adrenergic receptor function. , 1990, Science.

[59]  J. Petit,et al.  Isolation of UDP‐N‐glycolylmuramyl‐(Ala, Glu, DAP) from mycobacterium phlei , 1970, FEBS letters.

[60]  J. Way,et al.  Use of constitutive G protein-coupled receptor activity for drug discovery. , 2000, Molecular pharmacology.

[61]  J. Baldassare,et al.  Nuclear envelope signaling-role of phospholipid metabolism. , 2000, European Journal of Histochemistry.

[62]  V. Sah,et al.  The role of Rho in G protein-coupled receptor signal transduction. , 2000, Annual review of pharmacology and toxicology.

[63]  S. Pyne,et al.  Sphingosine 1-phosphate signalling in mammalian cells. , 2000, The Biochemical journal.

[64]  A. Scheer,et al.  Constitutively active G protein-coupled receptors: potential mechanisms of receptor activation. , 1997, Journal of receptor and signal transduction research.

[65]  R. Graham,et al.  Constitutive activation of a single effector pathway: evidence for multiple activation states of a G protein-coupled receptor. , 1996, Molecular pharmacology.

[66]  G. Milligan,et al.  Inverse agonism: pharmacological curiosity or potential therapeutic strategy? , 1995, Trends in pharmacological sciences.