Atlantoaxial Misalignment Causes High Blood Pressure in Rats: A Novel Hypertension Model

Atlantoaxial disorders are often correlated with hypertension in practice. In order to study the relationship between atlantoaxial disorder and hypertension, we attempted to construct an animal model. In this work, we presented an animal model where their atlantoaxial joints were misaligned. We investigated the changes of blood pressure before and after treatments of the modeled rats. We had the following results. (1) SBP and DBP of each surgery group were significantly higher than those of control and sham groups. (2) After the second operation (the fixture was removed), SBP and DBP of both surgery groups decreased and got closer to the control and sham groups after 7 days. (3) Heart rates got significantly higher in both surgery groups, compared to control and sham groups. (4) The blood Ach levels of the surgery groups were significantly lower than those of control and sham groups. With these results, we concluded that we successfully constructed cervical atlantoaxial disorder models in rats that showed hypertension symptom. However, the underlying mechanism connecting atlantoaxial disorder and hypertension still requires further study.

[1]  G. Lamas,et al.  Effect of Spinal Manipulation of Upper Cervical Vertebrae on Blood Pressure: Results of a Pilot Sham-Controlled Trial. , 2016, Journal of manipulative and physiological therapeutics.

[2]  N. Theodore,et al.  Persistent Outpatient Hypertension Is Independently Associated with Spinal Cord Dysfunction and Imaging Characteristics of Spinal Cord Damage among Patients with Cervical Spondylosis. , 2015, World neurosurgery.

[3]  Bin Chen,et al.  Surgical Treatment of Cervical Spondylotic Myelopathy Associated Hypertension—A Retrospective Study of 309 Patients , 2015, PloS one.

[4]  A. M. S. Jorgensen,et al.  Effects of Upper and Lower Cervical Spinal Manipulative Therapy on Blood Pressure and Heart Rate Variability in Volunteers and Patients With Neck Pain: A Randomized Controlled, Cross-Over, Preliminary Study. , 2015, Journal of chiropractic medicine.

[5]  X. Pang,et al.  Cervical Spondylosis and Hypertension , 2015, Medicine.

[6]  G. Bakris,et al.  Efficacy of baroreflex activation therapy for the treatment of resistant hypertension. , 2013, EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.

[7]  A. Ploumis,et al.  Cervicogenic hypertension - A possible etiology and pathogenesis of essential hypertension , 2012 .

[8]  J. Kuo,et al.  Sympathetic activation increases basilar arterial blood flow in normotensive but not hypertensive rats. , 2012, American journal of physiology. Heart and circulatory physiology.

[9]  O. Kizu,et al.  Neurovascular Decompression of the Rostral Ventrolateral Medulla Decreases Blood Pressure and Sympathetic Nerve Activity in Patients With Refractory Hypertension , 2011, Journal of clinical hypertension.

[10]  Waleska C Dornas,et al.  Animal models for the study of arterial hypertension , 2011, Journal of Biosciences.

[11]  J. Kuo,et al.  Axo‐axonal interaction in autonomic regulation of the cerebral circulation , 2011, Acta physiologica.

[12]  Edzard Ernst,et al.  Spinal manipulation: an update of a systematic review of systematic reviews. , 2011, The New Zealand medical journal.

[13]  L. Savastano,et al.  A standardized surgical technique for rat superior cervical ganglionectomy , 2010, Journal of Neuroscience Methods.

[14]  A. Walker,et al.  Sympathetic nerve activity in the superior cervical ganglia increases in response to imposed increases in arterial pressure. , 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

[15]  G. Bakris,et al.  Atlas vertebra realignment and achievement of arterial pressure goal in hypertensive patients: a pilot study , 2007, Journal of Human Hypertension.

[16]  K. Lotun,et al.  Practice-based randomized controlled-comparison clinical trial of chiropractic adjustments and brief massage treatment at sites of subluxation in subjects with essential hypertension: pilot study. , 2002, Journal of manipulative and physiological therapeutics.

[17]  G. A. Knutson.  Significant changes in systolic blood pressure post vectored upper cervical adjustment vs resting control groups: a possible effect of the cervicosympathetic and/or pressor reflex. , 2001, Journal of manipulative and physiological therapeutics.

[18]  D. Reis,et al.  The Cl Area of the Brainstem in Tonic and Reflex Control of Blood Pressure State of the Art Lecture , 1988, Hypertension.

[19]  Haruo Misawa,et al.  Development of dysphagia and trismus developed after c1-2 posterior fusion in extended position. , 2013, Acta medica Okayama.

[20]  Wu Zi-jian.  Effect of Pulling Cervical Sympathetic Ganglia on Blood Pressure in Rabbit , 2013 .

[21]  H. Namba,et al.  Cerebral hemorrhage due to posterior reversible encephalopathy syndrome associated with autonomic dysreflexia in a spinal cord injury patient. , 2012, Neurologia medico-chirurgica.

[22]  A. Razi,et al.  Rheumatoid arthritis of the cervical spine--clinical considerations. , 2011, Bulletin of the NYU hospital for joint diseases.

[23]  Cheng Jun-jun.  Clinical Analysis About the Relationship Between Lantoaxial Subluxation and Sympathetic Cervical Spondylosis , 2010 .

[24]  Liu Ming-hui.  Experimental study on Cervical vertebra-associated Dysarteriotony , 2007 .

[25]  D. Newell,et al.  Chiropractic manipulation affects the difference between arterial systolic blood pressures on the left and right in normotensive subjects. , 2006, Journal of manipulative and physiological therapeutics.