Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1−/− mice

[1]  V. Macrae,et al.  Optimisation of the differing conditions required for bone formation in vitro by primary osteoblasts from mice and rats , 2014, International journal of molecular medicine.

[2]  F. Henson,et al.  New insights into the location and form of sclerostin. , 2014, Biochemical and biophysical research communications.

[3]  I. Novak,et al.  UTP-induced ATP release is a fine-tuned signalling pathway in osteocytes , 2013, Purinergic Signalling.

[4]  T. Arnett.  Osteocytes: Regulating the Mineral Reserves? , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[5]  T. Arnett,et al.  Extracellular ATP Released by Osteoblasts Is A Key Local Inhibitor of Bone Mineralisation , 2013, PloS one.

[6]  B. Macias,et al.  Paradoxical Sost gene expression response to mechanical unloading in metaphyseal bone. , 2013, Bone.

[7]  M. Bouxsein,et al.  Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading , 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[8]  T. Craig,et al.  Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium , 2013, Proceedings of the National Academy of Sciences.

[9]  Roland Baron,et al.  WNT signaling in bone homeostasis and disease: from human mutations to treatments , 2013, Nature Medicine.

[10]  V. Macrae,et al.  New insights into NPP1 function: lessons from clinical and animal studies. , 2012, Bone.

[11]  G. Burnstock,et al.  The regulation of osteoblast function and bone mineralisation by extracellular nucleotides: The role of p2x receptors. , 2012, Bone.

[12]  M. Bouxsein,et al.  Serum sclerostin increases in healthy adult men during bed rest. , 2012, Journal of Clinical Endocrinology and Metabolism.

[13]  L. Bonewald,et al.  Isolation and culture of primary osteocytes from the long bones of skeletally mature and aged mice. , 2012, BioTechniques.

[14]  N. Fazzalari,et al.  Increased proportion of hypermineralized osteocyte lacunae in osteoporotic and osteoarthritic human trabecular bone: implications for bone remodeling. , 2012, Bone.

[15]  J. Millán,et al.  Altered Bone Development and an Increase in FGF-23 Expression in Enpp1−/− Mice , 2012, PloS one.

[16]  M. McCulloch,et al.  Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6. , 2012, American journal of human genetics.

[17]  T. Arnett,et al.  Rodent osteoclast cultures. , 2012, Methods in molecular biology.

[18]  U. Kornak.  Animal models with pathological mineralization phenotypes. , 2011, Joint, bone, spine : revue du rhumatisme.

[19]  N. Hatch,et al.  Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) Protein Regulates Osteoblast Differentiation , 2011, The Journal of Biological Chemistry.

[20]  G. Dubyak,et al.  Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle. , 2011, American journal of physiology. Heart and circulatory physiology.

[21]  J. Millán,et al.  The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells , 2011, PloS one.

[22]  L. Bonewald,et al.  The Amazing Osteocyte , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[23]  H. Seifarth,et al.  Expression of NPP1 is regulated during atheromatous plaque calcification , 2009, Journal of cellular and molecular medicine.

[24]  Michael Hahn,et al.  Decrease in the Osteocyte Lacunar Density Accompanied by Hypermineralized Lacunar Occlusion Reveals Failure and Delay of Remodeling in Aged Human Bone , 2022 .

[25]  T. Arnett.  Acidosis, hypoxia and bone. , 2010, Archives of biochemistry and biophysics.

[26]  Guoyin Feng,et al.  Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β‐Catenin Signaling , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[27]  G. Burnstock,et al.  Hypoxia stimulates vesicular ATP release from rat osteoblasts , 2009, Journal of cellular physiology.

[28]  Matthew R Allen,et al.  Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin* , 2008, Journal of Biological Chemistry.

[29]  G. Burnstock,et al.  Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate. , 2007, Endocrinology.

[30]  H. Donahue,et al.  Oscillating fluid flow activation of gap junction hemichannels induces atp release from MLO‐Y4 osteocytes , 2007, Journal of cellular physiology.

[31]  R. Vigneri,et al.  PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity , 1996, Diabetologia.

[32]  T. Arnett,et al.  Hypoxia inhibits the growth, differentiation and bone-forming capacity of rat osteoblasts. , 2006, Experimental cell research.

[33]  K. Clément,et al.  Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes , 2005, Nature Genetics.

[34]  R. Terkeltaub,et al.  Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice. , 2005, The American journal of pathology.

[35]  R. Terkeltaub,et al.  Chondrogenesis Mediated by PPi Depletion Promotes Spontaneous Aortic Calcification in NPP1−/− Mice , 2005, Arteriosclerosis, thrombosis, and vascular biology.

[36]  H. Fleisch,et al.  Pyrophosphatase and ATPase of isolated cartilage matrix vesicles , 1977, Calcified Tissue Research.

[37]  R. Terkeltaub,et al.  Inorganic pyrophosphate (PPI) in pathologic calcification of articular cartilage. , 2005, Frontiers in bioscience : a journal and virtual library.

[38]  T. Arnett,et al.  Acidosis Inhibits Bone Formation by Osteoblasts In Vitro by Preventing Mineralization , 2005, Calcified Tissue International.

[39]  R. Terkeltaub,et al.  Subcellular targeting and function of osteoblast nucleotide pyrophosphatase phosphodiesterase 1. , 2004, American journal of physiology. Cell physiology.

[40]  T. Arnett,et al.  Hypoxia is a major stimulator of osteoclast formation and bone resorption , 2003, Journal of cellular physiology.

[41]  R. Terkeltaub,et al.  Linked Deficiencies in Extracellular PPi and Osteopontin Mediate Pathologic Calcification Associated With Defective PC‐1 and ANK Expression , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[42]  T. Arnett,et al.  Isolated osteoclast cultures. , 2003, Methods in molecular medicine.

[43]  R. Terkeltaub,et al.  Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[44]  R. Terkeltaub.  Inorganic pyrophosphate generation and disposition in pathophysiology. , 2001, American journal of physiology. Cell physiology.

[45]  M. Pfaffl,et al.  A new mathematical model for relative quantification in real-time RT-PCR. , 2001, Nucleic acids research.

[46]  R. Terkeltaub,et al.  Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1. , 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

[47]  R. Terkeltaub,et al.  Germline deletion of the nucleoside triphosphate pyrophosphohydrolase (NTPPPH) plasma cell membrane glycoprotein (PC-1) produces abnormal calcification of periarticular tissues , 1999 .

[48]  Yusuke Nakamura,et al.  Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine , 1998, Nature Genetics.

[49]  G. Reaven,et al.  Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus , 1995, Nature.

[50]  D. Dempster,et al.  Effect of pH on bone resorption by rat osteoclasts in vitro. , 1986, Endocrinology.

[51]  L. Bélanger,et al.  The life cycle of the osteocyte. , 1973, Clinical orthopaedics and related research.

[52]  H. Fleisch,et al.  Isolation from urine of pyrophosphate, a calcification inhibitor. , 1962, The American journal of physiology.

[53]  O. J. Dunn.  Multiple Comparisons among Means , 1961 .

[54]  W. E. Razzell,et al.  Studies on polynucleotides. III. Enzymic degradation; substrate specificity and properties of snake venom phosphodiesterase. , 1959, The Journal of biological chemistry.

[55]  C. Dunnett.  A Multiple Comparison Procedure for Comparing Several Treatments with a Control , 1955 .