Temperature evolution during compaction of pharmaceutical powders.

A numerical approach to the prediction of temperature evolution in tablet compaction is presented here. It is based on a coupled thermomechanical finite element analysis and a calibrated Drucker-Prager Cap model. This approach is capable of predicting transient temperatures during compaction, which cannot be assessed by experimental techniques due to inherent test limitations. Model predictions are validated with infrared (IR) temperature measurements of the top tablet surface after ejection and match well with experiments. The dependence of temperature fields on speed and degree of compaction are naturally captured. The estimated transient temperatures are maximum at the end of compaction at the center of the tablet and close to the die wall next to the powder/die interface.

[1]  Takao Kato,et al.  Energy partition in conventional surface grinding , 1999 .

[2]  I. C. Sinka,et al.  The effect of wall friction in the compaction of pharmaceutical tablets with curved faces: a validation study of the Drucker–Prager Cap model , 2003 .

[3]  Sia Nemat-Nasser,et al.  Determination of temperature rise during high strain rate deformation , 1998 .

[4]  Changquan Calvin Sun,et al.  True density of microcrystalline cellulose. , 2005, Journal of pharmaceutical sciences.

[5]  Ranga Komanduri,et al.  Analysis of heat partition and temperature distribution in sliding systems , 2001 .

[6]  L. Anand,et al.  Thermal aspects of shear localization in microporous viscoplastic solids , 1992 .

[7]  S. Srčič,et al.  The role of the surface free energy in the selection of a suitable excipient in the course of a wet-granulation method , 2005 .

[8]  Pierre Tchoreloff,et al.  Modelling the compaction behaviour of powders: application to pharmaceutical powders , 2002 .

[9]  I. C. Sinka,et al.  Analysis of tablet compaction. II. Finite element analysis of density distributions in convex tablets. , 2004, Journal of pharmaceutical sciences.

[10]  J. Dodds,et al.  The effects of ambient temperature on the compaction of pharmaceutical powders , 2006 .

[11]  F. Dimaggio,et al.  MATERIAL MODEL FOR GRANULAR SOILS , 1971 .

[12]  D. N. Travers,et al.  Temperature changes occurring during the compression and recompression of solids , 1970, The Journal of pharmacy and pharmacology.

[13]  Bruno C. Hancock,et al.  Modelling the mechanical behaviour of pharmaceutical powders during compaction , 2005 .

[14]  A. L. Titchener,et al.  The Stored Energy of Cold Work , 1973 .

[15]  I. Saracovan,et al.  Measurement of the surface energy of lubricated pharmaceutical powders by inverse gas chromatography. , 2006, International journal of pharmaceutics.

[16]  S. Bechard,et al.  Infrared Imaging of Pharmaceutical Materials Undergoing Compaction , 1992, Pharmaceutical Research.

[17]  K. Marshall,et al.  Thermodynamic analysis of compact formation; compaction, unloading, and ejection. II. Mechanical energy (work) and thermal energy (heat) determinations of compact unloading and ejection. , 2001, International journal of pharmaceutics.

[18]  M. Strømme,et al.  Viscoelastic characterization of compacted pharmaceutical excipient materials by analysis of frequency-dependent mechanical relaxation processes , 2005, The European physical journal. E, Soft matter.

[19]  L. Périer-Camby,et al.  Influence of temperature on the compaction of an organic powder and the mechanical strength of tablets , 2006 .

[20]  K. Marshall,et al.  Thermodynamic analysis of compact formation; compaction, unloading, and ejection. I. Design and development of a compaction calorimeter and mechanical and thermal energy determinations of powder compaction. , 2000, International journal of pharmaceutics.

[21]  L. King,et al.  Thermodynamic effects in the compression of solids. , 1968, Journal of pharmaceutical sciences.

[22]  Mary C. Boyce,et al.  Effects of strain rate, temperature and thermomechanical coupling on the finite strain deformation of glassy polymers , 1995 .

[23]  D. Gethin,et al.  Model for Thermal Analysis in Cold Uniaxial Powder Compaction , 1998 .

[24]  R. G. Hollenbeck,et al.  Determination of the energy of tablet formation during compression of selected pharmaceutical powders , 1983 .

[25]  P. Paronen,et al.  Temperature changes during tabletting measured using infrared thermoviewer , 1993 .

[26]  I. C. Sinka,et al.  Analysis of tablet compaction. I. Characterization of mechanical behavior of powder and powder/tooling friction. , 2004, Journal of pharmaceutical sciences.

[27]  Robert T. DeHoff,et al.  Thermodynamics in Materials Science , 1993 .

[28]  M. Kaviany.  Principles of heat transfer in porous media , 1991 .

[29]  Geoff G. Z. Zhang,et al.  Phase transformation considerations during process development and manufacture of solid oral dosage forms. , 2004, Advanced drug delivery reviews.

[30]  I. Ward.  The role of molecular networks and thermally activated processes in the deformation behavior of polymers , 1984 .